A5100358842- Coal Properties and Utilization
- Microbial Inactivation Methods
- Catalysis for Biomass Conversion
- Virus-based gene therapy research
- Geothermal Energy Systems and Applications
- Catalysis and Hydrodesulfurization Studies
- Safety and Risk Management
- Catalysts for Methane Reforming
- Water Quality and Pollution Assessment
- Inflammatory Bowel Disease
- Microfluidic and Bio-sensing Technologies
- Eosinophilic Esophagitis
- Hydrological Forecasting Using AI
- Cancer Research and Treatments
- Trace Elements in Health
- Gastric Cancer Management and Outcomes
- High Altitude and Hypoxia
- Toxin Mechanisms and Immunotoxins
- Cancer-related molecular mechanisms research
- Combustion and Detonation Processes
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Groundwater and Isotope Geochemistry
- Nutrition, Genetics, and Disease
- CAR-T cell therapy research
Chengdu University
2024-2025
Nanjing University of Chinese Medicine
2025
Qilu Hospital of Shandong University
2022-2025
Central South University
2019-2025
Xiangya Hospital Central South University
2025
Hunan Cancer Hospital
2019-2024
Liaocheng People's Hospital
2022-2023
Fuda Cancer Hospital
2016-2023
Jinan University
2016-2023
Anhui Medical University
2021-2023
Neutrophil elastase (NE), a typical hematopoietic serine protease, has significant roles in inflammatory and immune responses, thus is highly associated with various diseases such as acute lung injury (ALI) cancer. Rapid accurate measurement of NE activity biological systems particularly important for understanding the role diseases, well clinical diagnosis. However, specific detection noninvasive imaging vivo remains challenge. To address this issue, small-molecule substrate based...
As the underground engineering proceeds to a greater depth, thermal stresses resulted from high-temperature surrounding rock become major challenge for deep construction and safe operation. Understanding of characteristics heat moisture transfer in roadway is critically required assist predicting improving environment underground. The present work developed fully coupled model capable simulating non-isothermal flow inside together with driven by water evaporation. And proposed has been...
The improved survival rate of ovarian cancer (OC) is related to the action infiltrating cytotoxic T lymphocytes (CTLs). Recently, oncolytic adenoviruses (OAds) have emerged as a key player in treating solid tumors; however, immunosuppressive tumor microenvironment (TME) and body-mediated antiviral immune response limit their therapeutic effect. In this study, we tested hypothesis that bispecific T-cell engagers (BiTEs) could activate redirect CTLs increase anti-tumor effect OAds. We modified...
<title>Abstract</title> Background Renal dysfunction is a frequent complication after kidney transplantation, leading to poor prognosis and increased mortality. Abnormal blood lipids are closely related renal dysfunction, yet their associations mechanisms among transplant recipients remain unclear. This study aimed establish an effective risk prediction model for RTRs based on abnormal lipid profiles using machine learning. Methods retrospective cohort recruited of 345 followed up one year...
Background: The causal relationship between blood lipids and colorectal cancer (CRC) risk has been preliminarily explored in previous Mendelian randomization (MR) studies, but these investigations were limited to conventional or partial metabolic lipid profiles. Recent advancements genome-wide association studies of plasma lipidomics have expanded our understanding categories, underscoring the need evaluate associations a broader range types CRC enhance assessment. Methods: This MR study...
Our understanding of water and salt changes in the context declining groundwater levels Tarim Basin remains limited, largely due to scarcity hydrological monitoring stations field observation data. This study utilizes data from 474 apparent electromagnetic induction (ECa, measured by EM38-MK2 device) sites across seven oases, combined with level representative areas, analyze spatiotemporal ECa within oases 2000 2022. Specific results are shown below: Numerous algorithmic predictions show...
Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine implicated in a wide range of cellular functions and known to be dysregulated various diseases such as cancer. Compared most other kinases, CK2 exhibits several unusual properties, including dual co-substrate specificity high degree promiscuity with hundreds substrates described date. Most paradoxical, however, its apparent constitutive activity: no definitive mode catalytic regulation has thus far been identified. Here we...
Xiang and Kele pigs are two well-known local Chinese pig breeds that possess rich genetic resources have enormous economic scientific value. We performed a comprehensive genomic analysis of the copy number variations (CNVs) in these breeds. CNVs one most important forms variation profound effects on phenotypic variation. In this study, PorcineSNP60 genotyping data from 98 22 were used to identify CNVs. total, 172 candidate CNV regions (CNVRs) identified, ranging 3.19 kb 8175.26 covering...
With the increasing number of high-temperature mines, there has been a growing focus on research into thermal environment management and prediction in long-distance ventilation roadways. Mastering principles heat transfer roadways is crucial for enhancing performance achieving energy savings mine hazard control. A one-dimensional ultra-long roadway with high precision low weight presented this study, which accurately depicts dynamic between airflow three-dimensional surrounding rock (SR)...
Irreversible electroporation (IRE) is a novel local tumor ablation approach with the potential to stimulate an antitumor immune response. However, it not effective in preventing distant metastasis isolation. This study aimed compare of augmenting response patients locally advanced pancreatic cancer (LAPC) who underwent IRE combined chemotherapy and PD-1/PD-L1 blockade those chemotherapy.A retrospective review was conducted on LAPC treated either combination (group A) or alone B) from July...
A steady and proper thermal environment in deep underground is imperative to ensure worker health production safety. Understanding the performance roadway premise of temperature prediction; ventilation design; improvement cooling efficiency. full coupled model incorporated with a moving mesh method was adopted; reflecting dynamic condition construction. This study revealed characteristics its evolution law an excavating roadway. Several scenarios were performed examine designs auxiliary...
This study aimed to investigate the safety and effectiveness of irreversible electroporation ablation for unresectable large liver cancer. Fourteen patients were enrolled: 8 with hepatocellular carcinoma (tumor diameter: 5.1-11.5 cm) 6 medium 3.0-4.1 cm). All received percutaneous ablation. Ablation time incidence complications assessed by a t test. Post-irreversible regular contrast-enhanced computerized tomography scans performed effect tumor size (large vs medium) on treatment efficacy;...
There are abundant mineral resources in plateau areas, but it is difficult to extract them safely because the problem of hypoxia mines seriously affects life and health workers. In order address blind heading a metal mine, three-dimensional roadway model was established based on field data Pulang copper mine Yunnan province, China. The computational fluid dynamics (CFD) method used explore optimal type oxygen supply duct outlet, reveal diffusion law influencing different ventilation factors....
A novobiocin derivative, XN4, has been shown to promote cell apoptosis in chronic myeloid leukaemia.This study explores the mechanism by which XN4 promotes ferroptosis of gastric cancer (GC) cells.Human GC SGC-7901 and BGC-823 cells were treated with different concentrations (0, 0.1, 0.5, 1.0, 5.0, 10.0 μmol/L) evaluate effects XN4. Additionally, pre-treated for 24 h si-NOX4, 1 iron chelator deferoxamine mesylate (DFO) or lipid peroxidation inhibitor liproxstatin-1 before being analyse...