A5066202169- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Cardiac electrophysiology and arrhythmias
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- RNA Research and Splicing
- Liver Disease and Transplantation
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Ion channel regulation and function
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Viral Infections and Immunology Research
Hunan Cancer Hospital
2015-2025
Central South University
2015-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2025
Guangdong Ocean University
2023
University of South China
2023
Nanjing Medical University
2019-2022
Qingdao University
2017-2022
Huazhong University of Science and Technology
2008-2020
Second Affiliated Hospital of Nanjing Medical University
2020
Army Medical University
2012-2018
Previous studies have shown that the N6-methyladenosine (m6A) modification enhances binding ability of mRNAs/long noncoding RNAs (lncRNAs) to microRNAs (miRNAs), but impact this on competitive endogenous RNA (ceRNA) function circular (circRNAs) is unclear.We used a human circRNA microarray detect expression profiles circRNAs in 3 pairs cancer and paracancerous tissues from patients with colorectal (CRC) peripheral blood specimens CRC healthy individuals. The highly expressed both tumour CRC,...
Abstract The aim of this retrospective study was to investigate the prognostic significance pre-treatment immunological and nutritional statuses in patients with locally advanced gastric cancer (GC), use risk factors develop a predictive score. A total 731 who underwent gastrectomy for stage II/III GC from November 2010 December 2015 were recruited into study. On basis univariate further multivariate Cox regression analyses, decreased pretreatment lymphocyte count (<1·5×10 9 /litre)...
Background: Bromodomain-containing protein 4(BRD4) is reported to play a vital role in the development of numerous malignant diseases, which considered as promising target for cancer therapy.AZD5153, novel specific BRD4 inhibitor, showed potent anticancer effects several types, but its therapeutic potential has not been fully evaluated colorectal cells.Objective: We sought evaluate inhibition by AZD5153 and combined effect with PARP inhibitor BMN673 vitro vivo cancer.Methods: analyzed The...
The aim of this study was to evaluate the prevalence anxiety in endometrial cancer patients undergoing total hysterectomy and analyze socio-demographic clinical factors contributing anxiety, with goal informing targeted psychological support interventions settings. employed a cross-sectional survey design, including 74 who underwent between January 2019 2024 at our hospital. Data were collected through combination face-to-face interviews self-administered questionnaires, conducted by...
Background Mycoplasma genitalium , a prokaryotic microorganism, is known pathogen of sexually transmitted infections. Previously, we identified cyclophilin A (CypA) as the membrane receptor on human urethral epithelial cells (SV-HUC-1) that binds to M. protein adhesion (MgPa) and demonstrated recombinant MgPa (rMgPa) inhibits apoptosis via CypA-mediated regulation PI3K/AKT/NF-κB pathway. Given established interplay between autophagy apoptosis, this study aims investigate whether rMgPa in...
MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects miR-22 renal cell carcinoma (RCC). results indicated that miR‑22 was tumor tissue from patients with RCC. In addition, lower levels were associated histological grade, stage lymph node metas-tasis. Following transfection RCC cells miR‑22, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, migration, invasion luciferase...
Abstract Background Photodynamic therapy (PDT) can be performed as palliative for cholangiocarcinoma, while there is currently insufficient evidence the efficacy. The aim of this study was to explore clinical efficacy and safety endoscopic retrograde cholangiopancreatography (ERCP)- or percutaneous transhepatic cholangioscopy (PTCS)-directed PDT combined with stent placement unresectable hilar cholangiocarcinoma. Methods A retrospective analysis conducted on 62 patients Thirty received using...
Abstract Astragalus polysaccharide (APS), the main extract from traditional Chinese medicinal herb membranaceus , has been reported to benefit treatment of immune‐inflammatory diseases and metabolic disorders. In atherosclerotic plaques, proinflammatory cytokines exert adverse effects on lipids thereby aggravating atherosclerosis. Recent evidence shows that tumor necrosis factor‐alpha (TNF‐α) can down‐regulate expression ATP‐binding cassette transporter A1 (ABCA1), which plays a vital role...
Allogeneic blood transfusions (BTF) are sometimes inevitable during radical gastrectomy with lymphadenectomy for advanced gastric cancer. The aim of this retrospective study was to investigate the association between BTF and post-operative infections, focusing on impact timing, amount transfusion role leukocyte depletion.The cohort 2064 patients who underwent cancer from November 2010 August 2017. infections estimated by univariate multivariate analyses after propensity score matching....
To investigate whether smoking adversely affects the short-term outcomes and potential effects of cigarette dose preoperative cessation, in patients who underwent gastric cancer (GC) surgery. Two thousand, four hundred sixty-nine consecutive radical gastrectomy from November 2010 to July 2018 were included present study. Smokers (current or former smokers) divided into 3 groups accordance with duration cessation preoperatively (≤ 2, 2 4, ≥ 4 weeks) 20, 20 40, 40 pack-years). The primary...
The burden of breast cancer (BC) has exacerbated over decades. Paclitaxel resistance is responsible for increasing BC treatment burden. Nuclear receptor binding SET domain-containing protein 1 (NSD1) positively correlated with a poor prognosis in patients BC. This study investigates the function NSD1 paclitaxel-resistant (PR) cells. high levels and Wnt10b PR cell lines (MCF-7/PR) or MCF-7 parental cells were determined by RT-qPCR. Western blotting was conducted to measure protein,...
Abstract Background/objective To investigate the influence of pre-operative immunological and nutritional status, assessed by prognostic index (PNI) score, on post-operative infection, potential additive effects low PNI infection prognosis after radical resection stage II/III gastric cancer (GC). Methods The medical records 2352 consecutive GC patients who underwent gastrectomy were retrospectively reviewed. independent predictors for infections identified using univariate multivariate...
Abstract Gastric cancer (GC) seriously threatens human health. High mobility group protein B1 (HMGB1) and M2‐like macrophages are closely associated with core events about cancers, such as invasion, metastasis, microenvironment. This study mainly determined the regulatory effect of HMGB1 in GC cell‐derived exosomes on macrophage polarization well underlying mechanism. was found to be highly expressed gastric tissue specimens, which might lead poor prognosis GC. levels were also observed...
Abstract Epstein‐Barr virus (EBV) infection is one of the causes gastric cancer (GC). Besides, previous studies have demonstrated that EBV‐encoded latent membrane protein 2A (LMP2A) influences pathogenesis EBV‐associated (EBVaGC) through regulating several key pathways. In this study, expression level Smad2 was observed, which reduced in EBVaGC cell lines, especially presence LMP2A. Meanwhile, we found LMP2A promoted miR‐155‐5p by activated nuclear factor‐κB (NF‐κB) signaling. After being...
Rationale: Epstein-Barr virus (EBV) is found in ~7% of gastric carcinoma cases worldwide, and all tumour cells harbour the clonal EBV genome. can regulate pathways protein expression to induce carcinoma; however, molecular mechanism underlying EBV-associated (EBVaGC) remains elusive. Methods: GEO microarray experiments were performed compare CXCR4 between EBV-positive EBV-negative (EBVnGC). Transfections with LMP2A plasmid or siRNA carried out assess role expression. The effects mechanisms...