A5037385416- Angiogenesis and VEGF in Cancer
- Heavy Metal Exposure and Toxicity
- Atherosclerosis and Cardiovascular Diseases
- Alzheimer's disease research and treatments
- Linguistics, Language Diversity, and Identity
- Redox biology and oxidative stress
- Translation Studies and Practices
- Ubiquitin and proteasome pathways
- Swearing, Euphemism, Multilingualism
- Arsenic contamination and mitigation
- RNA modifications and cancer
- Multilingual Education and Policy
- Vascular Malformations Diagnosis and Treatment
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Language, Discourse, Communication Strategies
- Interpreting and Communication in Healthcare
- Protease and Inhibitor Mechanisms
- Carcinogens and Genotoxicity Assessment
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Inflammatory Biomarkers in Disease Prognosis
- Mercury impact and mitigation studies
- Bioactive Compounds and Antitumor Agents
Nanjing University of Chinese Medicine
2025
Nanjing Drum Tower Hospital
2022-2024
Sun Yat-sen University
2010-2024
Wuhan University
2024
Yulin Orthopedics Hospital of Chinese and Western Medicine
2024
University of California, Irvine
2021-2022
Yangtze University
2017-2021
State Key Laboratory of Oncology in South China
2019
Yale University
2006-2016
The Jane Goodall Institute
2015
Dry eye disease (DED) is a multifactorial disease, and oxidative stress plays crucial role in its pathogenesis. Recently, multiple studies have shown that upregulation of autophagy can protect the cornea from damage. The present study investigated therapeutic effects salidroside, main component Rhodiola crenulata, both vivo vitro dry models. results showed topical drop treatment with salidroside restored corneal epithelium damage, increased tear secretion, reduced inflammation DED mice....
We have previously shown that ASK1-interacting protein 1 (AIP1) transduces tumor necrosis factor-induced ASK1-JNK signaling. Because endoplasmic reticulum (ER) stress activates signaling cascade, we investigated the role of AIP1 in ER stress-induced created AIP1-deficient mice (AIP1-KO) from which mouse embryonic fibroblasts and vascular endothelial cells were isolated. AIP1-KO show dramatic reductions stress-induced, but not oxidative activation cell apoptosis. The IRE1-JNK/XBP-1 axis,...
We have previously shown that ASK1 undergoes ubiquitination and degradation in resting endothelial cells (EC) proinflammatory cytokine tumor necrosis factor (TNF) induces deubiquitination stabilization, leading to activation. However, the mechanism for regulation of stability is not known. In present study, we SOCS1, a member suppressor signaling, degradation. SOCS1 was constitutively expressed EC formed labile complex with can be stabilized by proteasomal inhibitors. The...
Small ubiquitin-like modifier (SUMO) modification of proteins (SUMOylation) and deSUMOylation have emerged as important regulatory mechanisms for protein function. SENP1 (SUMO-specific protease) deconjugates SUMOs from modified proteins. We created knockout (KO) mice based on a Cre–loxP system. Global deletion (SENP1 KO) causes anemia embryonic lethality between day 13.5 postnatal 1, correlating with erythropoiesis defects in the fetal liver. Bone marrow transplantation KO liver cells to...
Background: The causal relationship between blood lipids and colorectal cancer (CRC) risk has been preliminarily explored in previous Mendelian randomization (MR) studies, but these investigations were limited to conventional or partial metabolic lipid profiles. Recent advancements genome-wide association studies of plasma lipidomics have expanded our understanding categories, underscoring the need evaluate associations a broader range types CRC enhance assessment. Methods: This MR study...
Objective— Thioredoxin-2 (Trx2), a major antioxidant protein in mitochondria, enhances nitric oxide bioavailability and inhibits ASK1-dependent apoptosis endothelial cells (ECs). However, the vivo role of Trx2 angiogenesis has not been defined. Here we used EC-specific transgenesis (Trx2-TG) mice to determine function arteriogenesis angiogenesis. Methods Results— In femoral artery ligation model, Trx2-TG had enhanced capacity limb perfusion recovery ischemic reserve compared nontransgenic...
Vascular endothelial growth factor receptor(VEGFR)-3 is a critical regulator of developmental and adult vasculogenesis lymphangiogenesis through its interactions with select members the VEGF family. The goal this study was to investigate how VEGFR-3 expression regulated during inflammatory lymphangiogenesis.In study, we present for first time evidence that can be negatively by mirtron, hsa-miR-1236 (miR-1236), which expressed in primary human lymphatic cells. In cells, miR-1236 upregulated...
We have previously shown that the tumor necrosis factor receptor 2 (TNFR2) protein is highly upregulated in vascular endothelium response to ischemia, and a global deletion of TNFR2 mice blunts ischemia-induced arteriogenesis angiogenesis. However, role endothelial not defined. In this study, we used cell (EC)-specific transgenesis (TNFR2-TG) determine vivo function angiogenesis.In femoral artery ligation model, TNFR2-TG had enhanced limb perfusion recovery ischemic reserve capacity. also...
Bmx, [corrected] also known as Etk, is a member of the Tec family nonreceptor tyrosine kinases. Bmx expressed mainly in arterial endothelia and myeloid hematopoietic cells. regulates ischemia-mediated arteriogenesis lymphangiogenesis, but its role tumor angiogenesis not known. In this study, we characterized function growth using both knockout transgenic mice. Isogenic colon, lung, melanoma xenotransplants showed reductions gene-deleted ((-/-)) mice, whereas developmental was affected....
Memory loss is the key symptom of Alzheimer's disease (AD). As successful drug treatments have not yet been identified, non-pharmaceutical interventions such as physical exercise and training employed to improve memory function people with dementia. We investigated effect prolonged running on hippocampal-dependent spatial its underlying mechanisms using a well-established rodent model AD. 3xTg-AD transgenic mice non-transgenic were subjected voluntary wheel for 5 months (1 hour per day, days...
Herpes simplex keratitis (HSK) is a blinding disease caused by herpes virus type 1 (HSV-1) infection, and rapid eradication of the from affected cornea imperative. Nod-like receptors (NLRs) are intracellular innate immune sensors closely associated with cell death, inflammation responses. In this study, we investigated role NLRP12 in antiviral immunology HSK underlying mechanisms. We found that expression was significantly decreased HSV-1-infected human corneal epithelial cells (HCE-Ts)...
Purpose This study aimed to clarify the prognostic utility of high-sensitivity C-reactive protein (hs-CRP) in nasopharyngeal carcinoma (NPC) patients Intensity-Modulated Radiotherapy (IMRT) era. Patients and Methods In this observational study, 1,589 non-metastatic NPC treated with IMRT were recruited. Blood samples collected before treatment for examination hs-CRP levels. We evaluated association pretreatment levels overall survival rate (OS), progression free (PFS), locoregional relapse...
Hyperthermia as an anticancer method has been paid increasing attention in recent years. Several studies have shown that hyperthermia can kill tumor cells by inducing apoptosis. However, the underlying molecular mechanisms of hyperthermia-induced apoptosis are largely unknown. To investigate effects and mechanism on renal carcinoma 786-O cells, we firstly examined Ku expression cell line treated with heat exposure (42°C for 0-4 h). The results showed induced suppressed significantly Ku80...
Herpes simplex keratitis (HSK) is a severe, infectious corneal disease caused by herpes virus type 1 (HSV-1) infection. The increasing prevalence of acyclovir resistance, the side effects hormonal drugs, and ease recurrence after surgery have made it crucial to develop new methods treating HSK. HSV-1 evades host immune response through various mechanisms. Therefore, we explored role immunogenic cell death inducer PKHB1 peptide in After subconjunctival injection peptide, observed ocular...
Studies from tumor cells suggest that tumor-suppressor AIP1 inhibits epithelial-mesenchymal transition (EMT). However, the role of in microenvironment has not been examined. We show a global or vascular endothelial cell (EC)-specific deletion gene mice augments growth and metastasis melanoma breast cancer models. AIP1-deficient environment only enhances neovascularization increases premetastatic niche formation, but also secretes EMT-promoting factors. These effects loss are associated with...
Purposes The objectives of this paper are to study the impact low level isopropyl alcohol exposure on blood pressure and explore its potential mechanism. Methods This cross-sectional was based a prospective occupational cohort in south China, which focusing risk factors related cardiovascular health problems. A total 283 participants (200 exposed workers 83 controls) finally enrolled study. Linear regression models were used analyze relationship between arterial pressures exposure. We...