A5067563692- AI in cancer detection
- Thyroid Cancer Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- Cancer-related molecular mechanisms research
- Hematopoietic Stem Cell Transplantation
- Allergic Rhinitis and Sensitization
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Artificial Intelligence in Healthcare and Education
- RNA modifications and cancer
- Thyroid and Parathyroid Surgery
- Graphene and Nanomaterials Applications
- Ultrasound and Hyperthermia Applications
- Eosinophilic Disorders and Syndromes
- Blood Pressure and Hypertension Studies
- Dermatology and Skin Diseases
- Cardiovascular Health and Disease Prevention
- Head and Neck Anomalies
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
Affiliated Hospital of Guizhou Medical University
2017-2024
Guiyang Medical University
2019-2024
Hebei University of Chinese Medicine
2024
Peking University
2018-2024
Capital Medical University
2023-2024
Beijing Children’s Hospital
2023-2024
Jiangsu University of Science and Technology
2024
Northwest University
2024
First Affiliated Hospital Zhejiang University
2024
Peking University International Hospital
2024
Although miR-125b plays a crucial role in many human cancers. However, its function heart failure (HF) remains unclear. Our study aimed to investigate involvement failure.In this study, the mouse HF model was successfully constructed through transverse aortic constriction (TAC) operation. Changes mRNA and protein levels isolated myocytes tissues were examined using qRT-PCR, Western blot Immunohistochemical staining immunofluorescent staining. cardiac functions ultrasound. Interactions...
Studies on deep learning (DL)-based models in breast ultrasound (US) remain at the early stage due to a lack of large datasets for training and independent test sets verification. We aimed develop DL model differentiating benign from malignant lesions US using multicenter dataset explore model's ability assist radiologists.A total 14,043 images 5012 women were prospectively collected 32 hospitals. To model, patients 30 hospitals randomly divided into cohort (n = 4149) an internal 466). The...
Background Artificial intelligence (AI) models have improved US assessment of thyroid nodules; however, the lack generalizability limits application these models. Purpose To develop AI for segmentation and classification nodules in using diverse data sets from nationwide hospitals multiple vendors, to measure impact on diagnostic performance. Materials Methods This retrospective study included consecutive patients with pathologically confirmed who underwent equipment 12 vendors at 208 across...
Carotid intima-media thickness (IMT) and diameter, stiffness, wave reflections, are independent important clinical biomarkers risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values carotid properties healthy Chinese adults explore potential determinants.
Abstract Background The incidence of inborn errors metabolism (IEM) varies across countries and areas. Currently, there are no studies on IEM using newborn screening (NBS) in eastern coastal areas China. We aimed to estimate the genetic variants understand spectrum diseases caused by among them this area. Methods NBS performed tandem mass spectrometry (MS/MS) from 2016 2021 was retrospectively reviewed. Heel blood collected all newborns 72 h after birth. Targeted massively parallel...
A major challenge of combinatorial therapy is the unification pharmacokinetics and cellular uptake various drug molecules with precise control dosage thereby maximizing combined effects. To realize ratiometric delivery synchronized release different drugs from a single carrier, novel approach was designed in this study to load dual onto macromolecular carrier molar ratio by covalently preconjugating through peptide linkers form conjugates. In contrast loading individual types separately,...
We present a Human Artificial Intelligence Hybrid (HAIbrid) integrating framework that reweights Thyroid Imaging Reporting and Data System (TIRADS) features the malignancy score predicted by convolutional neural network (CNN) for nodule stratification diagnosis. defined extra ultrasonographical from color Doppler images to explore malignancy-relevant features. proposed Gated Attentional Factorization Machine (GAFM) identify second-order interacting trained via 10 fold distribution-balanced...
Purpose: To develop and to validate a risk-predicted nomogram for downgrading Breast Imaging Reporting Data System (BI-RADS) category 4a breast lesions.Patients Methods: We enrolled 680 patients with lesions that were diagnosed as BI-RADS by conventional ultrasound from December 2018 June 2019.All randomly divided into development validation groups at the ratio of 3:1.In group consisting 499 cases, multiple clinical predicted factors extracted, dual-predicted nomograms constructed...
Objective: Cervical lymph node metastasis (LNM) was found to be clinically significant prognostic factors of patients with papillary thyroid carcinomas (PTC). Ultrasound (US) characteristics nodules and parenchyma may used predict LNM. To investigate the value nodular US features as well parenchymal microcalcifications on in predicting LNM PTC. Methods: This prospective study approved by Institutional Review Board. From January 2018 June 2019, 971 consecutive solitary PTC who underwent...
K (lysine) acetyltransferase (KAT) 5, which is a member of the KAT family enzymes, has been found to act as regulatory factor in various types cancer. However, role KAT5 anaplastic thyroid carcinoma (ATC) and its underlying mechanism still elusive. The expression levels kinesin 11 (KIF11) ATC cells were assessed utilizing reverse transcription-quantitative PCR western blot analyses. cell proliferative ability was via Cell Counting Kit-8 assay using 5-ethynyl-2'-deoxyuridine staining. Flow...
Objectives: To assess the performance of elastography (ES) and ultrasound (US) in predicting malignancy breast lesions to compare their combined diagnostic value with that magnetic resonance imaging (MRI). Materials Methods: The study prospectively enrolled 242 female patients dense breasts treated 35 heath care facilities China between November 2018 October 2019. Based on conventional US elastography, radiologists classified degree suspicion according Breast Imaging Reporting Data System...
The aims of our study were (1) to assess the right ventricular (RV) myocardial mechanics by two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography (STE) in patients with an ischemic or non-ischemic etiology end-stage heart failure (HF) (2) explore which RV index evaluated 2D- 3D-STE was most powerful indicator for identifying etiologies HF.A total 96 left ejection fraction (LVEF) < 30% enrolled study: 42 (mean age, 52 ± 10 years; 9.5% female) cardiomyopathy 54 46...
Abstract Background Atopic dermatitis (AD) is a chronic inflammatory skin disease. Human interleukin‐10 + B cells (B10 cells) one of regulatory and enriched in CD19 CD24 hi CD38 cells. A little known about these atopic dermatitis. Objective To study their clinical significance Chinese adult patients with Methods Thirty‐two AD nineteen healthy controls were enrolled. Peripheral blood mononuclear (PBMCs) isolated stained fluorescein‐conjugated monoclonal antibodies for CD19, CD24, CD27,...
Background Although specific IgE antibodies reactive to exogenous antigens are found in patients with atopic dermatitis (AD), some do not have such antibodies. Autoimmunity has been proposed as a possible mechanism these patients. Objectives To identify human transglutaminase 3 (TG3) and tropomysin (TMP) determine whether auto-reactive T cells induced by proteins AD. Materials & methods Forty-two AD 27 healthy controls were included this study. against recombinant TG3 TMP measured ELISA....
Doxorubicin and galactose were chemically conjugated to dextran by the carboxypropyl spacers conjugate was formulated into nanoparticle with free doxorubicin. The content of doxorubicin as high 17.2% in nanoscale drug delivery systems (nano-DDSs) size less than 190 nm. In an vitro cytotoxicity experiment, nano-DDSs had higher DOX against resistant HepG2 cells. a human tumor xenograft nude mouse model, generated therapeutic effect These promising data show better anti-tumor efficacy on cells...
Left ventricular hypertrophy (LVH) is common in endogenous hypertension (EH). We evaluated annexin A5 (ANXA5) promoter polymorphism a cross-sectional study with total of 850 EH patients, including 337 patients LVH. Genotyping ANXA5 single nucleotide polymorphisms (SNPs) was conducted by SNaPshot assays and statistical analyses were performed to quantify its association Of all potential SNPs, rs1050606 showed significant LVH (P = .008 dominant P .006 codominant models, respectively). During...