A5114734483- Gut microbiota and health
- Tendon Structure and Treatment
- Foot and Ankle Surgery
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Curcumin's Biomedical Applications
- Physical Unclonable Functions (PUFs) and Hardware Security
- Neurogenetic and Muscular Disorders Research
- Caching and Content Delivery
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Proteoglycans and glycosaminoglycans research
- Microbial Metabolism and Applications
- Musculoskeletal synovial abnormalities and treatments
- Ginger and Zingiberaceae research
- Osteoarthritis Treatment and Mechanisms
- Plant-Microbe Interactions and Immunity
- Periodontal Regeneration and Treatments
- Enhanced Recovery After Surgery
- Hemoglobin structure and function
The University of Texas at Austin
2022-2025
Southwest Medical University
2025
University of Oxford
2025
Nanjing Medical University
2021-2024
Wuhan Polytechnic University
2024
Jiangsu Province Hospital
2022-2024
Konkuk University
2022
Nanjing Agricultural University
2013
Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive hydrogel...
Disruption of the blood-spinal cord barrier (BSCB) leads to inflammatory cell infiltration and neural death, thus, contributing poor functional recovery after spinal injury (SCI). Previous studies have suggested that Sirtuin 1 (SIRT1), an NAD+-dependent class III histone deacetylase, is abundantly expressed in endothelial cells promotes homeostasis. However, role SIRT1 BSCB function SCI remains poorly defined. Here, we report highly cells, its expression significantly decreases SCI. Using...
Despite the diversity of reactions catalyzed by 2-oxoglutarate-dependent nonheme iron (Fe/2OG) enzymes identified in recent years, only a limited number these have been investigated mechanistic detail. In particular, several Fe/2OG-dependent capable catalyzing isocyanide formation reported. While glycine moiety has as biosynthon for group, how actual conversion is effected remains obscure. To elucidate catalytic mechanism, we characterized two previously unidentified (AecA and AmcA) along...
Formycin A and pyrazofurin are two naturally occurring pyrazole-derived C-nucleosides with antibacterial antiviral activities. While earlier studies have established the chemistry of C-glycosidic bond formation as well subsequent steps in biosynthesis formycin pyrazofurin, how pyrazole ring itself is constructed remains elusive. N-N was previously reported to involve coupling N6-hydroxylated l-lysine l-glutamic acid catalyzed by hydrazine synthetase PyfG, herein PyfG its homologue ForJ shown...
Stereoselectivity of the Pictet–Spengler reaction catalyzed by KslB resolved crystal structure enzyme-product complex.
The growing demand for improved batteries underscores the importance of measuring and un- derstanding ion transport within electrolytes. Concentration gradient visualisation approaches have been proposed to characterise electrolyte properties by fitting experimentally measured concentration gradients with Newman’s model extract diffusion coefficient cation transference number. We recently introduced operando Raman analysis (ORGA) technique, which follows a similar approach combining...
Periodontal diseases, characterized by the loss of tooth-supporting structures, are highly prevalent in general population. The Neutrophil-Percentage-To-Albumin Ratio (NPAR) has been identified as a promising biomarker for systemic inflammation, but its relationship with periodontal disease not thoroughly investigated. Despite growing interest role other chronic conditions, specific connection between NPAR and remains underexplored requires further examination to understand potential...
Abstract Spinal cord injury (SCI) can result in severe motor and sensory deficits, for which currently no effective cure exists. The pathological process underlying this is extremely complex involves many cell types the central nervous system. In study, we have uncovered a novel function macrophage G protein‐coupled receptor kinase‐interactor 1 (GIT1) promoting remyelination functional repair after SCI. Using GIT1 flox/flox Lyz2‐Cre (GIT1 CKO) mice, identified that deficiency macrophages led...
Aerocyanidin and amycomicin are two antibiotics derived from long-chain acids with a rare epoxy isonitrile moiety, the complexity of which renders total synthesis these natural products rather challenging. How this functionality is biosynthesized has also remained obscure. While biosynthetic gene clusters for compounds have been identified, both appear to be deficient in genes encoding enzymes seemingly necessary oxidative modifications observed antibiotics. Herein, pathways aerocyanidin...
Abstract As a drug delivery system with wide application potential, serum albumin drug‐carrying nanoparticles have attracted extensive attention in the field of recent years. This review aims to summarize research progress drug‐loaded delivery. Firstly, excellent properties as carrier were introduced, several methods preparing discussed depth, and their advantages disadvantages compared. Then, design nanoparticle is discussed, including control size nanoparticle, surface amount loading, so...
Valanimycin is an azoxy-containing natural product isolated from the fermentation broth of Streptomyces viridifaciens MG456-hF10. While biosynthesis valanimycin has been partially characterized, how azoxy group constructed remains obscure. Herein, membrane protein VlmO and putative hydrazine synthetase ForJ formycin biosynthetic pathway are demonstrated to catalyze N-N bond formation converting O-(l-seryl)-isobutyl hydroxylamine into N-(isobutylamino)-l-serine. Subsequent installation shown...
The nonunion following a fracture is associated with severe patient morbidity and economic consequences. Currently, accumulating studies are focusing on the importance of macrophages during repair. However, details regarding process by which facilitate endochondral ossification (EO) largely unknown. In this study, we present evidence that apoptotic chondrocytes (ACs) not inert corpses awaiting removal, but positively modulate osteoinductive ability macrophages. vivo experiments revealed...
As the development trend of future housing field, green is an effective way to reduce pollution, save energy, and promote industrial upgrading. At same time, house great significance change mode construction industry sustainable social economy. This study proposes a comprehensive research model examine influencing mechanism residents' intention purchase buildings. The proposed empirically tested using data collected from 1,338 urban residents in China. Based on logit, probit, ivprobit...
The osteoarthritis caused by trauma or inflammation is associated with severe patient morbidity and economic burden. Accumulating studies are focusing on the repair of articular cartilage defects constructing tissue-engineered cartilage. Recent evidence suggests that optimizing source quality seed cells one key points tissue engineering. In this study, we demonstrated Kindlin-2 its activated PI3K/AKT signaling played an essential role in promoting extracellular matrix (ECM) secretion...
Kitasetaline is one of the very few β-carbolines isolated from bacteria. It features a unique
After spinal cord injury (SCI), phagocytes endocytose myelin debris to form foam cells, exacerbating the inflammatory response. It has been previously shown that macrophages become cells through phagocytosis of via receptor-dependent mechanisms after SCI. Blocking receptor-mediated endocytosis did not completely prevent cell formation, so we investigated receptor-independent endocytosis. Here, revealed formed internalization were predominantly rather than microglia. Receptor-independent...
In this work, polyacrylamide (PAM) was first used in the loading of heteropoly acids, and then HPM/PAM-n catalyst synthesized by simple reaction. The FTIR SEM measurements showed that (n = 10,000, 20,000, 30,000) successfully synthesized. addition, effect on desulfurization measured, which optimal efficiency. process condition for HPM/PAM-10000 optimized a single-factor experiment. as follows: temperature 60 °C, amount 0.2 g, oxygen to sulfur ratio 16, reaction time is 100 min. suitable...
Abstract Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive...