A5073939786- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Enhanced Oil Recovery Techniques
- Advanced Photocatalysis Techniques
- Supramolecular Self-Assembly in Materials
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Vestibular and auditory disorders
- DNA and Nucleic Acid Chemistry
- Perovskite Materials and Applications
- Luminescence and Fluorescent Materials
- Gas Sensing Nanomaterials and Sensors
- Covalent Organic Framework Applications
- Pickering emulsions and particle stabilization
- Plant Gene Expression Analysis
- Glaucoma and retinal disorders
- Hydraulic Fracturing and Reservoir Analysis
- Petroleum Processing and Analysis
- Peptidase Inhibition and Analysis
- Ophthalmology and Visual Impairment Studies
- Antimicrobial Peptides and Activities
- Quality and Safety in Healthcare
- Metal Alloys Wear and Properties
National Center for Nanoscience and Technology
2019-2024
China University of Petroleum, East China
2021-2024
Wuhan Polytechnic University
2023-2024
Hebei University
2024
Northwest A&F University
2023
Zhejiang Chinese Medical University
2022-2023
Lanzhou University
2023
Huazhong University of Science and Technology
2023
Institute of Theoretical Physics
2023
Huazhong Agricultural University
2016-2022
The morphology controlled molecular assemblies play vital roles in biological systems. Here we present endogenous reactive oxygen species (ROS)-triggered transformation of polymer-peptide conjugates (PPCs) for cooperative interaction with mitochondria, exhibiting high tumor therapeutic efficacy. PPCs are composed (i) a β-sheet-forming peptide KLVFF conjugated poly(ethylene glycol) through ROS-cleavable thioketal, (ii) mitochondria-targeting cytotoxic KLAK, and (iii) poly(vinyl alcohol)...
Abstract Solar‐driven activation of molecular oxygen, which harnesses light to produce reactive oxygen species for the removal pollutants, is most green and low‐cost approach environmental remediation. The energy coupling between photons, excitons, crucial step in this reaction still remains a challenge. In study, dual‐purpose strategy enhanced established by situ carbon homogeneous doping on ultrathin Bi 2 MoO 6 nanosheets first time. C‐doped 2D material exhibits an enlarged bandgap...
The shape of a drug delivery system impacts its in vivo behavior such as circulation time, accumulation, and penetration. Considering the advantages functional dyes bioapplications, we synthesize class nanoaggregates based on BF2-azadipyrromethene (aza-BODIPY) dyes, which can realize long blood deep tumor penetration simultaneously through morphological transformation modulated by near-infrared (NIR) laser. First, when temperature increases, wormlike nanofibers aza-BODIPY-1 aggregate,...
The in situ construction of the nanoassembly has been demonstrated to improve performance bioactive molecules, but control morphology nanomaterials vivo still remains a tremendous challenge. Herein, photothermal-promoted transformation (PMT) strategy is developed accelerate formation for improving biological drug molecules. Compared with spontaneous process, rate increases by ∼4 times PMT process. Owing increased assembly rate, tumor accumulation drugs ∼2-fold than that without photo...
Abstract The strategy of in vivo self‐assembly has been developed for improved enrichment and long‐term retention anticancer drug tumor tissues. However, most self‐assemblies with non‐covalent bonding interactions are susceptible to complex physiological environments, leading weak stability loss biological function. Here, we develop a coupling‐induced assembly (CIA) generate covalently crosslinked nanofibers, which is applied situ constructing artificial shell on mitochondria....
Mesocrystals are of great interest for a wide range applications owing to their unique structural features and properties. The realization well-defined metal oxide mesocrystals through facile green synthetic approach still remains challenge. Here, novel synthesis strategy is reported the production spindle-shaped anatase TiO2 with single-crystal-like structure, which was simply achieved one-step hydrolysis reaction TiCl3 in recyclable media polyethylene glycol (PEG-400) without any...
Bone marrow stromal cells (BMSCs) are known to promote chemoresistance in acute myeloid leukemia (AML) cells. However, the molecular basis for BMSC-associated AML remains largely unexplored.The mitochondrial oxidative phosphorylation (OXPHOS) levels of were measured by a Seahorse XFe24 cell metabolic analyzer. The activity total or signal transducer and transcription activator 3 (STAT3) was explored flow cytometry Western blotting. Real-time quantitative PCR, blotting enzyme-linked...
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with unknown etiology. CCN1, an extracellular matrix-associated protein, associated carcinoma, inflammation, fibrosis, and even autoimmune diseases. However, the role that CCN1 plays in AIH has remained undetermined. In this study, expression of was detected by real-time PCR, western blot immunohistochemistry (IHC). level serum ELISA. Diagnostic value determined receiver operating characteristic (ROC) curve analysis....
Abstract Local tumor recurrence after surgical resection is a critical concern in cancer therapy, and the current treatments, such as postsurgical chemotherapy, still show undesired side effects. Here nonimplant strategy (transformation induced localization, TIL) presented to situ construct long‐term retentive drug depots, wherein sustained release from fibrous depots results highly efficient suppression of local relapse. The peptide‐based prodrug nanoparticles favorable targeting instantly...
The skin-like wound dressings are developed for skin regeneration. on-demand release of antibacterial peptides and the subsequent in situ self-assembly realize both good biosafety high-efficiency efficacy.
In some malignant tumor, especially for pancreatic poor solid-tumor penetration of nanotherapeutics impedes their treatment efficacy. Herein, we develop a polymer-peptide conjugate with the deep tissue ability, which undergoes cascade process under ultrasound (US), including (1) singlet oxygen 1O2 is generated by P18, (2) thioketal bond cleaved 1O2, (3) departure PEG chains leads to in situ self-assembly, and (4) resultant self-assembled PK nanoparticles show considerable cellular...
Resolving individual gravitational waves from tens of millions double white dwarf (DWD) binaries in the Milky Way is a challenge for future space-based wave detection programs. By using previous data to define priors next search, we propose an accelerated approach searching DWD and demonstrate its efficiency based on GBSIEVER pipeline. Compared traditional method, our method can obtain $\sim 50\%$ sources with 2.5\% time LDC1-4 data. In addition, find that both methods have similar ability...
The interfacial dilational rheology of silica nanoparticles (NPs) directly reflects the relationship between surface structure and behaviors in NPs, which has attracted significant attention various industrial fields. In this work, modified (MNPs) with alkyl chain lengths were synthesized systematically characterized using Fourier transform infrared spectra, Zeta potential, water contact angle measurements. It was found that MNPs successfully fabricated similar degrees modification....
Protected cultivation is currently one of the main modes for grape production, but long-term use plastic film will have a certain negative impact on light environment in vineyards, which turn causes poor colouring, low sugar content and lack aroma some red varieties. Supplementing can be an effective way to mitigate these problems. In this study, vines three table varieties ('Summer Black', 'Xinyu' 'Queen Nina') cultivated greenhouse were supplemented with red, blue, white red-blue from...