A5017208958- Gut microbiota and health
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Child Nutrition and Feeding Issues
- COVID-19 and Mental Health
- Sleep and related disorders
- Transcranial Magnetic Stimulation Studies
- Clostridium difficile and Clostridium perfringens research
- Attention Deficit Hyperactivity Disorder
- Gaze Tracking and Assistive Technology
- Gastrointestinal motility and disorders
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Healthcare professionals’ stress and burnout
- Bacteriophages and microbial interactions
- Child and Adolescent Psychosocial and Emotional Development
- Sleep and Wakefulness Research
- Ophthalmology and Visual Impairment Studies
- Infant Health and Development
- Probiotics and Fermented Foods
- Heart Rate Variability and Autonomic Control
- Neural and Behavioral Psychology Studies
- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
Chinese University of Hong Kong
2019-2024
Tai Po Hospital
2018-2020
Emerging evidence suggests autism spectrum disorder (ASD) is associated with altered gut bacteria. However, less known about the viral community and its role in shaping microbiota neurodevelopmental disorders. Herein, we perform a metagenomic analysis of gut-DNA viruses 60 children ASD 64 age- gender-matched typically developing to investigate effect virome on host bacteria ASD. composition accompanied by enrichment Clostridium phage, Bacillus Enterobacteria phage. These ASD-enriched phages...
Emerging evidence of an altered gut microbiome in autism spectrum disorder (ASD) suggests a pathomechanism through the gut-brain axis despite inconsistent profile reported across studies. One knowledge gaps existing ASD microbiota studies is lack systematic exploration role comorbid functional gastrointestinal (FGID) association and microbiome. Consequently, 92 112 age-matched typically developing (TD) boys were profiled on general psychopathology, FGID status by Rome IV classification,...
Accumulating evidence suggests that gut microbiota alterations influence brain function and could serve as diagnostic biomarkers therapeutic targets. The potential of using fecal signatures to aid autism spectrum disorder (ASD) detection is still not fully explored. Here, we assessed the different levels microbial markers (taxonomy genome) in distinguishing children with ASD from age gender-matched typically developing peers (
Individuals with autism spectrum disorder (ASD) are challenged not only by the defining features of social-communication deficits and restricted repetitive behaviors, but also a myriad psychopathology varying in severity. Different cognitive underpin these psychopathologies, which could be subjected to intervention alter course disorder. Understanding domain-specific mediating effects cognition is essential for developing targeted strategies. However, high degree inter-correlation among...
Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in suggests complex reciprocal relationships, which are seldom explored non-treatment-seeking FGID. relationships between subtypes FGID anxiety also unclear. This study recruited boys age-matched typically developing (TD) boys, aged 4-11 years, who were not actively seeking help for problems. Their parents completed the Rome IV Diagnostic...
Study Objectives: The lifestyles change of children and adolescents during the COVID-19 pandemic due to antipandemic measures can affect their sleep health.Existing studies have used convenient samples focused on initial months pandemic, leaving a knowledge gap changes in young people's patterns under "new normal" COVID-19.Methods: As part territory-wide epidemiological study Hong Kong, this cross-sectional recruited primary secondary school students by stratified random sampling.Sleep...
Purpose:The cognitive neuropsychological model of depression suggests that the deficits observed in depressed subjects are result attenuated top-down control resulting increased bottom-up emotional processing.Remediation impairments cold cognition has been proposed as a valuable treatment for depression.The study aimed to examine effects clinical response repetitive transcranial magnetic stimulation (rTMS) on over course 8 weeks medication-refractory subjects.Materials and Methods:...
Cognitive impairment is a common phenomenon in Parkinson’s disease that has implications on the prognosis. A simple, noninvasive and objective proxy measurement of cognitive function will be helpful detecting early decline. As physiological metric, eye movement parameter not confounded by subject's attributes intelligence can as marker if it correlates with functions. To this end, study explored relationship between parameters performance tests multiple domains. In experiment, visual search...
Cognitive impairment is a common phenomenon in Parkinson’s disease that has implications on the prognosis. A simple, noninvasive and objective proxy measurement of cognitive function will be helpful detecting early decline. As physiological metric, eye movement parameter not confounded by subject's attributes intelligence can as marker if it correlates with functions. To this end, study explored relationship between parameters performance tests multiple domains. In experiment, visual search...
Abstract Background Lifestyle of children and adolescents have changed extensively during the COVID-19 pandemic due to school suspension social distancing measures, which can affect their sleep health. Existing studies in area used convenient samples focused on initial months pandemic. Method As part a territory-wide epidemiological study Hong Kong, this cross-sectional recruited primary secondary students by stratified random sampling. We investigated pandemic’s effects parameters using...