A5054868159- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Mitochondrial Function and Pathology
- Tea Polyphenols and Effects
- Ophthalmology and Visual Impairment Studies
- Cancer, Lipids, and Metabolism
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Advanced Glycation End Products research
- Connexins and lens biology
- Intraocular Surgery and Lenses
- melanin and skin pigmentation
- Receptor Mechanisms and Signaling
- Kruppel-like factors research
- Corneal Surgery and Treatments
- Connective Tissue Growth Factor Research
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Retinopathy of Prematurity Studies
- Pain Management and Treatment
Tianjin Medical University
2019-2025
Tianjin Medical University Eye Hospital
2019-2025
Nankai University
2013-2025
Cangzhou Central Hospital
2024
Wuhan University
2008-2018
Renmin Hospital of Wuhan University
2008-2018
The University of Adelaide
2012-2016
Hanson Institute
2013-2016
Chinese Academy of Inspection and Quarantine
2015
Wuhan Donghu University
2008
Purpose: Like cancer cells, photoreceptor cells produce lactate aerobically, requiring dehydrogenase A (LDH-A). Cancer also use glycolytic intermediates for biosynthesis. The molecular switch controlling flow is thought to be an isoenzyme of pyruvate kinase (PKM2). Here, we determined the expression and localization PKM2 LDH-A in mammalian retina make comparisons with brain. Methods: Single- double-labeling immunohistochemistry PKM2, M1 (PKM1), were performed using retinal sections from...
Purpose.: Both mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in the pathogenesis of neurodegenerative disorders. The purpose present study was to investigate mechanisms cellular damage resulting from induced cultured retinal cells and, particular, whether ER plays a role this response. Methods.: Mixed cell cultures containing neurons glia were prepared neonatal rats. complex I inhibitor rotenone employed induce dysfunction. Immunocytochemistry, Western...
Assessing metabolomic alterations in age-related macular degeneration (AMD) can provide insights into its pathogenesis. We compared the profiles of aqueous humor between wet AMD patients (n = 26) and age- sex-matched undergoing cataract surgery without as controls 20). A global untargeted metabolomics study was performed using ultra-high-performance liquid chromatography tandem mass spectrometry. Univariate analysis after false discovery correction showed 18 significantly altered metabolites...
Purpose To assess the efficacy and safety of preoperative intravitreal triamcinolone acetonide (IVTA) combined with internal limiting membrane (ILM) peeling for idiopathic epiretinal (IMEM).
Eye health is becoming a significant public concern, and recent epidemiological investigation suggested that perfluorooctanoic acid (PFOA), so-called forever chemical, was correlated with decreased human visual acuity; however, it remains unknown whether PFOA can pass through the blood-retinal barrier (BRB) to cause toxicity. In this study, mice received 28-day subchronic oral exposure PFOA. The results of spatial mass spectrometry imaging indicated eye-enriched dispersed into subretina...
Background/Objectives: Despite substantial research, the causal relationships between gut microbiota (GM) and age-related macular degeneration (AMD) remain unclear. We aimed to explore these associations using Mendelian randomization (MR) elucidate potential mechanisms mediated by blood metabolites. Methods: utilized 211 GM dataset (n = 18,340) provided MiBioGen consortium. AMD outcome data were sourced from MRC Integrated Epidemiology Unit (IEU) OpenGWAS Project. performed bidirectional MR,...
To investigate the impact of several allergic diseases on development keratoconus (KC) from a genetic perspective. Data multiple genome-wide association studies involving European ancestry individuals were used. Ultimately, 613 conjunctivitis (AC) cases and 474,657 controls, 4387 rhinitis (AR) 471,273 4859 asthma 135,449 1169 urticaria 212,464 22,474 atopic dermatitis 774,187 311 KC 209,287 controls included. Then inverse-variance weighted (IVW) method, potential pleiotropy, heterogeneity,...
The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, associated with alteration hippocampal short-term potentiation (STP) and long-term (LTP) discuss potential underlying mechanism. Young adult rats were randomly divided into three groups. groups include: control group (CC), 1 (NC), which their mothers received from gestational day 3 (GD3) GD18, 2 (CN), young postnatal 42 (PD42) PD56. Morris water maze (MWM) test...
Etiology and pathogenesis of age-related cataract is not entirely clear till now. Senescence marker protein 30 (SMP30) a newly discovered anti-aging factor, which plays an important role in preventing apoptosis reducing oxidative stress damage. Mitochondria are located at the intersection key cellular pathways, such as energy substrate metabolism, reactive oxygen species (ROS) production apoptosis. Oxidative induced by 4-hydroxynonenal (4-HNE) closely related to neurodegenerative diseases...
Purpose.: Previous experiments have demonstrated that short-term hyperglycemia in rats renders the retina resistant to subsequent metabolic insults. The present study aimed elucidate putative mechanisms involved this protective response. Methods.: Retinal cultures comprising neurons and glia were treated with mitochondrial complex I inhibitor, rotenone, at a range of concentrations, for up 24 hours. In some cases, glucose or alternative energy substrates, pyruvate lactate, and/or inhibitors...
The retinal pigment epithelial (RPE)/choroid complex regulates myopia development, but the precise pathogenesis of remains unclear. We aimed to investigate changes in RPE/choroid metabolism a form deprivation model after dopamine D2 receptor (D2R) modulation. Guinea pigs were randomly divided into normal (NC), (FDM), and FDM treated with D2R antagonist groups. Differential metabolites screened using SIMCA-P software MetaboAnalyst metabolomics analysis tool. Functions differential analyzed...
Abstract Purpose This study aims to evaluate the effect of subconjunctival glucose on retinal ganglion cells ( RGCs ) in experimental ischaemia and contrast sensitivity humans with primary open‐angle glaucoma POAG ). Methods First, we measured intravitreal concentration at various time points after a injection 100 μl 50% S prague‐ D awley rats. Next, treatment control groups received iso‐osmotic (8%) saline, respectively, 1 h prior unilateral ischaemic injury; 7 days later, damage profiles...
Purpose: Energy compromise underpins wet age-related macular degeneration (wAMD) pathogenesis, but the relationship between glucose metabolism and disease remains unclear. Here, we characterized aqueous humor (AH) to elucidate glucose-related metabolic signatures in patients with wAMD. Methods: In total, 25 eyes of wAMD were divided into phakic (15 eyes), pseudophakic (10 intravitreal injections ranibizumab (13 eyes) groups. Twenty cataract (21 served as controls. Ultrahigh-performance...
Abstract Background An imbalance in lipid metabolism has been linked to the development of AMD, but causal relationship between AMD and plasma fatty acids (FAs) remains controversial. Using a two-sample Mendelian randomization (MR) approach, we sought evaluate impact specific FA levels on risk different subtypes. Methods We analysed genome-wide association data circulating FAs from 115,006 European-descended individuals UK Biobank. These were used MR framework assess potential role...
Age-related macular degeneration is a metabolic compromise disorder whose main pathological feature choroidal neovascularization (CNV) formation. Using untargeted metabolomics analysis, we determined to assess the metabolomic alterations in CNV rat model provide an insight into its pathogenesis. In model, there were 24 significantly changed metabolites plasma and 71 various ocular tissues. Pathway analysis showed that certain pathways interrelated tissues: for instance, terms of altered urea...
Thirty laboratories from fom North and South America, Europe, Asia participated in this AOAC collaborative study (15 China; five Germany; two each Italy the United States; one Republic of Korea, Canada, Spain, Japan, Belgium, India). Participants represented government regulatory, commercial testing, university, research institute, private laboratories. The single-laboratory validated (SLV) tea method was evaluated to determine recovery reproducibility under multilaboratory conditions. Since...
Scope Choroidal neovascularization (CNV) is age‐related macular degeneration's (AMD) main pathological change. High‐fat diet (HFD) associated with a form of CNV; however, the specific mechanism unclear. Mitochondrial dysfunction, characterized by abnormal acylcarnitine, occurs during metabolic screening serum or other body tissues in AMD. This study investigates HFD's role retinal and pigment epithelium (RPE)/choroidal acylcarnitine metabolism CNV formation. Methods results Chow HFD‐BN rats...
This study aimed to investigate the changes in retinal neurotransmitters and role of dopamine D2 receptor (D2R) pathway regulating myopic refractive state. Tricolor guinea pigs were randomly divided into two groups: normal control group (NC) form-deprivation myopia (FDM). Animals FDM had their right eye covered with a balloon for 4 weeks. These groups further subgroups based on intravitreal injection D2R antagonist sulpiride once week 3 weeks (NC, NC-Sul, FDM, FDM-Sul groups)....