A5101714324- Epigenetics and DNA Methylation
- PARP inhibition in cancer therapy
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Glutathione Transferases and Polymorphisms
- Histone Deacetylase Inhibitors Research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- CRISPR and Genetic Engineering
- Photoacoustic and Ultrasonic Imaging
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Management of metastatic bone disease
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Brain Metastases and Treatment
Renmin Hospital of Wuhan University
2024-2025
Nankai University
2025
Wuhan University
2024-2025
North Shore Diabetes and Endocrine Associates
2025
Peking University
2009-2024
Northwell Health
2023-2024
Harvard University
2016-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2023
Brigham and Women's Hospital
2016-2023
Ribon Therapeutics (United States)
2019-2022
Abstract Prostate cancer harboring BRCA1/2 mutations are often exceptionally sensitive to PARP inhibitors. However, genomic alterations in other DNA damage response genes have not been consistently predictive of clinical inhibition. Here, we perform genome-wide CRISPR-Cas9 knockout screens BRCA1/2-proficient prostate cells and identify previously unknown whose loss has a profound impact on inhibitor response. Specifically, MMS22L deletion, frequently observed (up 14%) cancer, renders...
Abstract JARID1B is a member of the JmjC/ARID family demethylases that specifically demethylates tri- and di-methylated forms histone H3 lysine 4 (H3K4) are associated with active genes. expression dysregulated in several cancers which it has been implicated, but how might affect tumor progression unclear. In this study, we report physical component LSD1/NuRD complex functions transcriptional repression. LSD1 acted sequential coordinated manner to demethylate H3K4. A genome-wide analysis...
p53 hydroxylation by JMJD6 represents a novel post-translational modification for p53. JMJD6-mediated regulates p53's transcriptional activity and the p53-dependent control of colon cancer.
Androgen receptor (AR) is a ligand-activated transcription factor and key driver of prostate cancer (PCa) growth progression. Understanding the factors influencing AR-mediated gene expression provides new opportunities for therapeutic intervention. Poly(ADP-ribose) Polymerase (PARP) family enzymes, which posttranslationally modify range proteins regulate many different cellular processes. PARP-1 PARP-2 are two well-characterized PARP members, whose catalytic activity induced by DNA-strand...
Breast cancer remains the leading cause of cancer-related deaths among women worldwide, necessitating more effective treatment strategies. Chemotherapy combined with immunotherapy is first-line for breast cancer, but it still suffers from limited therapeutic efficiency and serious side effects, which are usually due to poor delivery efficiency, drug resistance tumor cells, immunosuppressive microenvironment. This study explores development ultrasound-responsive nanobubbles (Ce6/PTX Nbs)...
As the utility of Child-Pugh (C-P) class is limited by subjectivity ascites and encephalopathy, we evaluated a previously established objective method, albumin-bilirubin (ALBI) grade, as prognosticator for yttrium-90 radioembolization (RE) treatment patients with hepatocellular carcinoma (HCC).A total 117 who received RE HCC from 2 academic centers were reviewed stratified ALBI C-P class, Barcelona Clinic Liver Cancer stage. The overall survival (OS) according to these 3 criteria was...
Transcription regulation by histone modifications is a major contributing factor to the structural and functional diversity in biology. These are encrypted as codes or languages function establish maintain heritable epigenetic that define identity fate of cell. Despite recent advances revealing numerous associated with transcription regulation, how such dictate process not fully understood. Here we describe spatial temporal analyses introduced during estrogen receptor α (ERα)-activated...
Poly-ADP-ribose polymerases (PARPs) are a family of enzymes responsible for transferring individual or chains ADP-ribose subunits to substrate targets as type post-translational modification. PARPs regulate wide variety important cellular processes, ranging from DNA damage repair antiviral response. However, most research date has focused primarily on the polyPARPs, which catalyze formation polymer chains, while monoPARPs, transfer monomers, have not been studied thoroughly. This is...
Diabetic wounds remain a great challenge for clinicians globally as lack of effective radical treatment often results in poor prognosis. Exosomes derived from adipose‑derived stem cells (ADSC‑Exos) have been explored an appealing nanodrug delivery system the diabetic wounds. However, short half‑life and low utilization efficiency exosomes limit their therapeutic effects. Low‑intensity pulsed ultrasound (LIPUS) provides non‑invasive mechanical stimulus to exerts number biological effects such...
Background MicroRNAs (miRNAs) are small non‐coding RNAs, which negatively regulate gene expression and impact prostate cancer (PCa) growth progression. Circulating miRNAs stable detectable in cell‐free body fluids, such as serum. Investigation of circulating presents great potential uncovering new insights into the roles PCa diagnosis therapy. Methods Using TaqMan miRNA quantitative reverse transcription polymerase chain reaction (RT‐qPCR), we compared levels five (miR‐193a‐3p, miR‐9‐3p,...
Abstract Although androgen deprivation therapy (ADT) is an effective treatment for metastatic prostate cancer, incurable castration-resistant cancer (CRPC) inevitably develops. Importantly, receptor (AR) continues to be critical growth and progression after ADT. One of the underlying molecular mechanisms derepression AR-repressed genes involved in cell cycle proliferation Here, data demonstrate that C-X-C chemokine type 7 (CXCR7), a seven-transmembrane G-protein–coupled receptor, gene...
Overexpression and hyperactivation of the serine/threonine protein kinase B (AKT) pathway is one most common cellular events in breast cancer progression. However, nature AKT1-specific genome-wide transcriptomic alterations cells remains unknown to this point. Here, we delineate impact selective AKT1 knock down using gene-specific siRNAs or inhibiting AKT activity with a pan-AKT inhibitor VIII on changes RNA-sequencing analysis. We found that levels lead set differentially expressed genes...
Background: Prostate cancer (PCa) poses a significant global health threaten. Immunotherapy has emerged as novel strategy to augment the inhibition of tumor proliferation. However, sole use anti-PD-L1 Ab for PCa not yielded improvements, mirroring outcomes observed in other types. Methods: This study employed thin film hydration method develop lipid nanobubbles (NBs) encapsulating chlorin e6 (Ce6) and (Ce6@aPD-L1 NBs). Our experimental approach included cellular assays mouse immunization,...
Abstract Efficient thrombolysis in time is crucial for prognostic improvement of patients with acute arterial thromboembolic disease, while limitations and complications still exist conventional thrombolytic treatment methods. Herein, our study sought to investigate a novel dual-mode strategy that integrated ultrasound (US) near-infrared light (NIR) establishment hollow mesoporous silica nanoprobe (HMSN) which contains Arginine-glycine-aspartate (RGD) peptide (thrombus targeting),...
Abstract Background Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early accurate diagnosis crucial for effective treatment prognosis. Traditional invasive procedures such as image-guided prostate biopsy often discomfort complications, deterring some patients from undergoing these necessary tests. This study aimed to explore feasibility clinical value using ultrasound super-resolution imaging (US SRI) non-invasively assessing...
Abstract Purpose: Checkpoint inhibitors (ICIs) are being added to standard-of-care chemoradiotherapy in multiple clinical trials. The optimal sequencing of immunotherapy and remains widely debated. Therefore, we compiled available trials reviewed various aspects that may be associated with outcomes. Methods: We conducted a systematic literature review randomized controlled Phase 3 (RCTs) PubMed, ClinicalTrials.gov Google scholar from 1/1/2018 11/8/2024. included all seminal matured data,...
Eye health is becoming a significant public concern, and recent epidemiological investigation suggested that perfluorooctanoic acid (PFOA), so-called forever chemical, was correlated with decreased human visual acuity; however, it remains unknown whether PFOA can pass through the blood-retinal barrier (BRB) to cause toxicity. In this study, mice received 28-day subchronic oral exposure PFOA. The results of spatial mass spectrometry imaging indicated eye-enriched dispersed into subretina...