A5063743190- Plant nutrient uptake and metabolism
- Plant Micronutrient Interactions and Effects
- Pediatric health and respiratory diseases
- Pain Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Phase Change Materials Research
- Food Quality and Safety Studies
- Plant Stress Responses and Tolerance
- Solar Thermal and Photovoltaic Systems
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Metabolism, Diabetes, and Cancer
- Antibiotic Resistance in Bacteria
- Hypothalamic control of reproductive hormones
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Healthcare and Venom Research
- Traditional Chinese Medicine Analysis
- Legume Nitrogen Fixing Symbiosis
- Immune Response and Inflammation
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immune responses and vaccinations
Jiangsu University
2008-2024
Children's Hospital of Fudan University
2024
Aba Teachers University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Tianjin University of Sport
2024
Jiangxi College of Applied Technology
2024
Nanjing Agricultural University
2011-2022
The Synergetic Innovation Center for Advanced Materials
2022
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2017-2021
Guangxi University
2017-2021
The adaptive responses of plants to phosphate (Pi) starvation stress are fine-tuned by an elaborate regulatory network. In this study, we identified and characterized a novel Pi starvation-responsive gene, MYB1, encoding R2R3-type transcription factor in rice. MYB1 was transcriptionally induced leaf sheaths old blades. It localized the nucleus expressed mainly vascular tissues. Mutation led increase uptake accumulation, accompanied altered expression subset transporters several genes...
Abstract Inorganic phosphate (Pi) is the predominant form of phosphorus (P) readily accessible to plants, and Pi Transporter 1 (PHT1) genes are major contributors root uptake. However, mechanisms underlying transport recycling within which vital for optimizing P use efficiency, remain elusive. Here, we characterized a functionally unknown rice (Oryza sativa) PHT1 member barely expressed in roots, OsPHT1;7. Yeast complementation Xenopus laevis oocyte assay demonstrated that OsPHT1;7 could...
Plant Phosphate Transporter 1 (PHT1) proteins, probably the only influx transporters for phosphate (Pi) uptake, are partially degraded on sufficient Pi levels to prevent excessive accumulation. Therefore, basal/constitutive expression level of PHT1 genes is vital maintaining uptake under Pi-replete conditions. Rice (Oryza sativa) OsPHT1;1 a unique gene as it highly expressed and not responsive Pi, however mechanism its remains unknown. Using biochemical genetic approaches, we identified...
Long non-coding RNAs (lncRNAs) have previously been reported to be involved in cancer invasion, proliferation and apoptosis. However, the association between lncRNA, H19, esophageal (EC) has remained elusive. In present study, reverse transcription quantitative‑polymerase chain reaction revealed that expression of H19 was significantly increased associated with tumor depth metastasis 133 EC samples. Furthermore, MTT Transwell assays overexpression vitro promoted invasion cell lines, whereas...
Abstract Background: Approximately 1 woman in every 10 will develop breast cancer her lifetime. It has been shown that screening for can reduce mortality. The use of a saliva‐based test could prove to be very useful post‐operative and/or adjunctive therapy management patients. Methods: following study was undertaken establish the possible usefulness salivary protein product oncogene c ‐erbB‐2 patients diagnosed with carcinoma breast. Included this were 25 mean age 54 years varying...
The role of integrons in the spread antibiotic resistance has been well established. aim this study was to investigate profiles Pseudomonas aeruginosa isolated from patients Zhenjiang 13 antibiotics, and identify structure dissemination class 1 integrons.The Kirby-Bauer disk diffusion assay used determine rate P. resistance. Class multidrug-resistant isolates were amplified by PCR, their PCR products sequenced. We also analyzed integron structures containing same gene cassettes restriction...
In this study, we investigated the effects of minocycline, a putative suppressor microglial activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation, allodynia, and hyperalgesia in neonatal rats. Intraperitoneal (i.p.) injection LPS (2 mg/kg) or sterile saline was performed postnatal day 5 (P5) rat pups minocycline (45 vehicle (phosphate buffer saline; PBS) administered min after injection. The von Frey filament tail-flick tests were to determine mechanical allodynia...
Temozolomide (TMZ) is the standard of care chemotherapeutic agent used in treatment glioblastoma multiforme. Cytotoxic O6-methylguaine lesions formed by TMZ are repaired O6-methyl-guanine DNA methyltransferase (MGMT), a repair protein that removes alkyl groups located at O6-position guanine. Response to requires low MGMT expression and functional mismatch repair. Resistance conferred MGMT, tolerance O6-methylguanine deficient MMR severely limit clinical applications. Therefore, development...
Plant acclimatory responses to phosphate (Pi) starvation stress include the accumulation of carbohydrates, namely sugar and starch. However, whether altered endogenous carbohydrate profile could in turn affect plant Pi remains widely unexplored. Here, two genes encoding large small subunits an ADP-glucose pyrophosphorylase (AGP) rice (Oryza sativa), AGP Large Subunit 1 (AGPL1) Small (AGPS1), were functionally characterized with regard maintenance phosphorus (P) homeostasis regulation...
Abstract Plants have evolved delicate systems for stimulating or inhibiting inorganic phosphate (Pi) uptake in response to the fluctuating Pi availability soil. However, negative regulators at transcriptional level are largely unexplored. Here, we functionally characterized a transcription factor rice (Oryza sativa), OsWRKY10. OsWRKY10 encodes nucleus-localized protein and showed preferential tissue localization. Knockout of led increased accumulation under Pi-replete conditions. In...
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with homeobox transcription factor gene Hlx . Recent studies show that and Th1-associated factors are critical regulating tumor development. However, contributions occurrence development cancer remain unknown. In this study, , Runx3 IFN- γ were measured PBMC from patients gastric correlation between or was assessed. The expression levels IFN - significantly decreased, there a positive addition,...
This study aimed to investigate the anti-inflammatory effect of 4-methylcyclopentadecanone (4-MCPC) in rats suffering from a cerebral ischemia/reperfusion (I/R) injury. In this study, focal ischemia was induced by middle artery occlusion (MCAO) for 2 h, and were treated with 4-MCPC (8 mg/kg) just 0.5 h before reperfusion. The ischemic infarct volume recorded 24 after MCAO. addition, myeloperoxidase (MPO) activity TNF-α IL-1β levels cortex determined ELISA, while nuclear translocation NF-κB...
Much evidence suggests that trained immunity is inappropriately activated in the synovial tissue rheumatoid arthritis (RA), but underlying mechanism remains unclear. Here, we describe how RA-specific autoantibody deposits can train human monocytes to exert hyperactive inflammatory response, particularly via exacerbated release of tumor necrosis factor α (TNFα). Comparative transcriptomic analysis by plate-bound IgG (cIgG) or β-glucan indicated metabolic shift towards glycolysis a crucial for...