A5100338871- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Vascular Malformations and Hemangiomas
- Immune cells in cancer
- Cancer-related gene regulation
- Lymphatic Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- DNA Repair Mechanisms
- Genetic Syndromes and Imprinting
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Gyrotron and Vacuum Electronics Research
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Nankai University
2021
Tianjin Medical University
2010-2021
Tianjin First Center Hospital
2010-2021
Weatherford College
2020
Affiliated Hospital of Jining Medical University
2016
Since late December 2019, an outbreak of 2019 novel coronavirus diseases (COVID-19) in Wuhan, China has spread quickly nationwide. With the COVID-19, routine clinical diagnosis and treatment for lung cancer patients been disturbed. Due to systemic immunosuppressive caused by malignancy anticancer treatments, are more susceptible infection than healthy individuals. Furthermore, with had poorer prognosis from infection. Lung should be priority group COVID-19 prevention. The protection...
Coronary artery disease (CAD) requires more accurate diagnostic methods, for which circulating microRNAs (miRNAs) are promising non-invasive biomarkers. miR-208a and miR-370 two key molecules in cardiac hemostasis lipid metabolism, respectively. The aim of the present study was to evaluate their potency as biomarkers CAD. Plasma were quantitated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) using a TaqMan® MicroRNA Reverse Transcription PCR kit 95 CAD patients 50...
Non-small cell lung cancer is one of the most common types cancer, and prognosis non-small still poor. Recent evidence has proved that long noncoding RNA involved in tumorigenesis. For expression profile been studied. Here, we identified a novel TRPM2-AS from published dataset found widely upregulated tissues compared with adjacent non-tumor tissues. Higher level was correlated higher TNM stages larger tumor size. Patients high had poor survival than those low level. We silenced by small...
Background/Aims: CircABCB10 function as an endogenous miRNA sponge plays important role in various tumors. This experimental design was based on circABCB10 to explore the pathogenesis of non-small cell lung cancer (NSCLC). Methods: CircRNA microarray used examine circRNA expression profiles from 3 NSCLC patients and paired healthy tissues. The miR-584-5p detected by q-PCR. CCK-8, colony formation, transwell assays study effects tumor growth migration invasiveness. To validate downstream...
Abstract It has been demonstrated in previous studies that lncPART1 is dysregulated non‐small cell lung cancer (NSCLC). However, the function of NSCLC unclear. Therefore, this experimental design was based on LncPART1 to explore pathogenesis NSCLC. Real‐time polymerase chain reaction used detect expression and miR‐17‐5p Cell Counting Kit ‐8, colony formation, transwell assays were examine effects proliferation migration invasiveness. Target gene prediction, luciferase reporter validate...
Folic acid-conjugated temozolomide (TMZ)-loaded chitosan nanoparticles (CS-TMZ-FLA-NP) were developed to target lung cancer in the anticipation that folic acid would increase affinity of for cells. CS-TMZ-FLA-NP showed highest anti-proliferative effect on cells comparison free TMZ and CS-TMZ-NP (nanoparticles without acid). A cellular uptake assay was performed two different cell lines, L132 A549. Cellular efficiencies found be concentration-dependent both lines. produced a 2.5 fold greater...
Primary idiopathic chylopericardium is a rare clinical entity characterized by the accumulation of chyle within pericardial cavity without definitive cause. The aim this study was to assess presentation, etiology, diagnosis, treatment and follow-up primary chylopericardium.We retrospectively reviewed 9 cases patients who suffered from at our hospital January 1993 November 2013.There were two males seven females among patients. Their ages ranged 13 55 years. most common presentation dyspnea....
Abstract Lung adenocarcinoma (LUAD) is the most common histological subtype in non-small cell lung cancer, which malignant tumor with highest mortality and morbidity world. Herein, ZNF280A, a member of zinc finger protein family carrying two consecutive Cys2His2 domains, was shown by us to act as driver LUAD. The immunohistochemical analysis ZNF280A LUAD indicated its positive correlation grade, pathological stage lymphatic metastasis, negative relationship patients’ survival. A...
Coronavirus disease 2019 (COVID‐19) is spreading worldwide, and has been declared as an international public health concern. Patients with lung cancer are highly susceptible to infection compared healthy individuals because of systemic immunosuppression induced by malignancy anticancer therapy. Furthermore, patients demonstrate poorer outcomes following infection. Hence, should be considered a priority group for COVID‐19 prevention. the routine treatment affected during pandemic, may not...
Non-small-cell lung cancer (lung cancer) has become one of the leading causes worldwide and underlying mechanism is not fully understood. The transcriptional factor Kruppel like 8 (KLF8) involved in initiation, progression, transformation, metastasis diverse cancers. However, roles KLF8 human non-small cell remain unknown.CCK-8 kit colony formation assay were performed to determine growth cells. Flow cytometry analysis was used evaluate apoptosis cycle Luciferase reporter examine activation...
MCM8 is a helicase, which participates in DNA replication and tumorigenesis upregulated many human cancers, including lung cancer (LC); however, the function of LC tumour progression unclear. In this study, we found that was expressed at high levels cells tissues. Further, upregulation associated with advanced grade lymph node metastasis, indicated poor prognosis. Silencing suppressed cell growth migration vitro vivo, while ectopic expression promoted cycle progression, as well migration,...
Abstract Background The advanced hepatocellular carcinoma (HCC), such as the recurrent tumor after liver transplantation (LT), is an obstacle of HCC treatment. aim this study was to discover underlying mechanism progression caused by non-coding RNAs (ncRNAs). Methods To end, we investigated selected patient cohort matching primary and receiving LT. tumors LT were regarded clinical models HCC. Microarrays used profile lncRNA mRNA expression in tissue samples. characteristics analyzed...
Accurate localization of pulmonary nodules is crucial for successful video-assisted thoracoscopic surgery (VATS) resection. Electromagnetic navigation bronchoscopy (ENB) combined with indocyanine green (ICG) fluorescence has emerged as a promising technique precise nodule marking. This study aims to evaluate the efficacy and safety four ENB-guided ICG marking techniques: direct lesion marking, superficial resection boundary margin sphere We prospectively enrolled 80 patients deep lung...
Abstract Background: Lung cancer is the most commonly diagnosed malignant tumor worldwide. adenocarcinoma (LUAD) common histological subtype in non-small cell lung (NSCLC). The relationship between ZNF280A and LUAD has not been demonstrated remains unclear. Methods: In this study, it was that upregulated tissues compared with normal tissues. Further investigations indicated overexpression/knockdown of could promote/inhibit proliferation, colony formation migration cells, while...
Microsatellite instability (MSI), high tumor mutation burden (TMB-H) and programmed cell death 1 ligand (PD-L1) expression are hot biomarkers related to the improvement of immunotherapy response. Two cohorts non-small-cell lung cancer (NSCLC) were collected sequenced via targeted next-generation sequencing. Drug analysis was then performed on shared genes using three different databases: Drugbank, DEPO DRUGSURV. A total 27 common mutated in at least two groups TMB-H-, MSI- PD-L1-positive...