A5103107160- Insect Resistance and Genetics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
Anhui Agricultural University
2023-2025
Nanjing Agricultural University
2019
RNA interference (RNAi) is being used to develop methods control pests, yet its widespread application limited by the high comprehensive cost of dsRNAs. Here, we utilized identity matching between double-stranded (dsRNA) and nontarget genes achieve expanding dsRNA insecticidal spectrum. First, found that was more likely induce off-target effects in with higher transcript levels sequence identity; existence either a completely contiguous exceeding 15 nt or partially 24 can lead Tribolium...
Double-stranded RNA (dsRNA) pesticides, those based on interference (RNAi) technology utilizing dsRNA, have shown potential for pest control. However, the off-target effects of dsRNA pose limitations to widespread application RNAi and raise concerns regarding side other beneficial organisms. The precise impact underlying factors these are still not well understood. Here, we found that transcript level sequence matching jointly regulate dsRNA. much lower expressed target genes were knocked...