A5052500734- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Vector-Borne Animal Diseases
- Neural dynamics and brain function
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Surgical Simulation and Training
- EEG and Brain-Computer Interfaces
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Animal Virus Infections Studies
- Radiomics and Machine Learning in Medical Imaging
- Bone fractures and treatments
University of California, San Diego
2010-2024
Salk Institute for Biological Studies
2014-2023
Iowa State University
2013-2021
University of Maryland, Baltimore
2020
Charing Cross Hospital
1999-2019
Imperial College Healthcare NHS Trust
2013-2019
Imperial College London
2014-2018
Duke Medical Center
1995-2016
Howard Hughes Medical Institute
2014-2016
National Hospital for Neurology and Neurosurgery
1996-2016
The causes of post-transfusion non-A, non-B hepatitis are still not fully defined, nor is it clear how accurate the tests that used to screen blood donors for C virus (HCV) and diagnose caused by infected blood.
Although targeting cancer metabolism is a promising therapeutic strategy, clinical success will depend on an accurate diagnostic identification of tumor subtypes with specific metabolic requirements. Through broad metabolite profiling, we successfully identified three highly distinct in pancreatic ductal adenocarcinoma (PDAC). One subtype was defined by reduced proliferative capacity, whereas the other two (glycolytic and lipogenic) showed levels associated glycolysis, lipogenesis, redox...
Abstract Selective kinase inhibitors have emerged as an important class of cancer therapeutics, and several such drugs are now routinely used to treat advanced-stage disease. However, their clinical benefit is typically short-lived because the relatively rapid acquisition drug resistance following treatment response. Accumulating preclinical data point a role for heterogeneous response within subpopulation tumor cells that intrinsically drug-resistant, stem cells. We previously described...
Titanium miniplates are used to secure the posterior elements in open position after expansive open-door laminoplasty. Preoperative and postoperative spinal canal dimensions measured assess effectiveness of this technique.To develop a simple yet effective technique stabilize laminoplasty compare preoperative accepted normal values.Expansive has been offered as alternative laminectomy, which associated with kyphosis. Although is effective, reliable method holding not described.Ten myelopathic...
Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all markers (triple negative or basal-like). While targeted therapies for ER+/PR+ HER2+ tumors have revolutionized patient treatment increased lifespan, an urgent need exists identifying novel targets triple-negative breast cancers. Here, we used integrative genomic analysis to identify candidate...
In order to efficiently characterize both antiproliferative potency and mechanism of action small molecules targeting the cell cycle, we developed a high-throughput image-based assay determine number cycle phase distribution. Using this profiled effects experimental approved anti-cancer agents with range mechanisms on set lines, comparing direct counting versus two metabolism-based viability/proliferation formats, ATP-dependent bioluminescence, MTS...
The acromioclavicular (AC) joint enjoys the dubious distinction of being one few joints in body whose total dislocation is routinely treated by simply leaving dislocated. Adherents both conserv ative and operative treatment have presented reasons for their viewpoints. Residual shoulder weakness has been offered as a sequela untreated acromioclavic ular injury reason repairing joint. An objective evaluation strength would be valuable determining optimum this injury. purpose our study was to...
Radioactive carbon dioxide was incubated with growing cells of Leptospira interrogans serotypes semaranga and tarassovi , the specific activities distribution label within cellular amino acids were determined. The origins skeletons all acid-stable except isoleucine found to be consistent known biosynthetic pathways for these acids. Experiments using radioactive other tracers indicated that most synthesized by a pathway not involving threonine. origin skeleton consisted two residues pyruvate...
Recent research in music and brain function has suggested that the temporal pattern structure rhythm can enhance cognitive functions. To further elucidate this question specifically for memory we investigated if a musical template verbal learning patients with multiple sclerosis assisted will also influence short-term, system-level plasticity. We measured systems-level activity oscillatory network synchronization during learning. Specifically, spectral power of 128-channel...
A series of trisubstituted hydroxylactams was identified as potent enzymatic and cellular inhibitors human lactate dehydrogenase A. Utilizing structure-based design physical property optimization, multiple were discovered with <10 μM IC50 in a MiaPaca2 cell line. Optimization the led to 29, active molecule (MiaPaca2 = 0.67 μM) that also possessed good exposure when dosed orally mice.