A5100692268- Adipose Tissue and Metabolism
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Food Allergy and Anaphylaxis Research
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Allergic Rhinitis and Sensitization
- Lung Cancer Research Studies
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Contact Dermatitis and Allergies
- Multiple Myeloma Research and Treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- Asthma and respiratory diseases
- Cancer Mechanisms and Therapy
- Physical Activity and Health
- Cancer, Lipids, and Metabolism
- Exercise and Physiological Responses
- ATP Synthase and ATPases Research
Hunan Normal University
2008-2025
Fudan University
2024-2025
Zhongshan Hospital
2024-2025
Xi'an Jiaotong University
2025
Wuyi University
2016-2024
Sun Yat-sen University
2019-2024
Shanghai Institute of Hematology
2024
Shenzhen University
2024
Shanghai Medical College of Fudan University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Multilayer ceramic capacitor as a vital core-component for various applications is always in the spotlight. Next-generation electrical and electronic systems elaborate further requirements of multilayer capacitors terms higher energy storage capabilities, better stabilities, environmental-friendly lead-free, etc., where these major obstacles may restrict each other. An effective strategy performance global optimization put up here by constructing local polymorphic polarization configuration...
Inhibition of the bromodomain transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed vivo chemical tool 1 (GNE-272) for CBP that was moderately potent and selective over BRD4(1). In pursuit a more inhibitor, we used structure-based design. Constraining aniline into tetrahydroquinoline motif maintained potency increased selectivity 2-fold. Structure–activity relationship studies coupled with further design targeting LPF...
Neuroinflammation occurs throughout the pathogenesis of Alzheimer's disease (AD). Here, we investigated effects treadmill exercise on neuroinflammation in APP/PS1 transgenic AD mice and potential involvement microbe-gut-brain axis (MGB) mechanisms based growing evidence that AD's is correlated with a deterioration function gut microbiota. were subjected to 12 weeks exercise, followed by spatial memory tests. After behavioral study, amyloid (Aβ) pathology, microbes metabolites, bacterial...
Background Hepatocellular carcinoma (HCC) is an exceptionally immunosuppressive malignancy characterized by limited treatment options and a dismal prognosis. Macrophages constitute the primary heterogeneous immune cell population within HCC microenvironment. Our objective to identify distinct subsets of macrophages implicated in progression their resistance immunotherapy. Methods Intratumoral macrophage-specific marker genes were identified via single-cell RNA sequencing analyses. The...
The single bromodomain of the closely related transcriptional regulators CBP/EP300 is a target much recent interest in cancer and immune system regulation. A co-crystal structure ligand-efficient screening hit CBP guided initial design targeting LPF shelf, ZA loop, acetylated lysine binding regions. Structure-activity relationship studies allowed us to identify more potent analogue. Optimization permeability microsomal stability subsequent improvement mouse hepatocyte afforded 59 (GNE-272,...
A growing body of clinical data has shown that patients with Alzheimerâs disease (AD) have symptoms such as liver dysfunction and microbialâgutâbrain axis in addition to brain pathology, presenting a systemic multisystemic pathogenesis. Considering the benefits exercise, here, we first observed effects long-term treadmill exercise on injuries APP/PS1 transgenic AD mice explored potential mechanisms gutâliverâbrain axisâs role mediating exerciseâs ability reduce bacterial...
A series of trisubstituted hydroxylactams was identified as potent enzymatic and cellular inhibitors human lactate dehydrogenase A. Utilizing structure-based design physical property optimization, multiple were discovered with <10 μM IC50 in a MiaPaca2 cell line. Optimization the led to 29, active molecule (MiaPaca2 = 0.67 μM) that also possessed good exposure when dosed orally mice.
The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway in hepatocellular carcinoma (HCC) is limited. NOD-like receptors (NLRs) comprise a highly evolutionarily conserved family cytosolic bacterial sensors, yet their impact on antitumor immunity against HCC remains unclear. In this study, we uncovered that NOD1, well-studied member NLR family, exhibits predominant expression tumor-associated macrophages (TAMs) and correlates positively with improved prognosis responses to anti–PD-1...
Abstract Given that glioma stem cells (GSCs) play a critical role in the initiation and chemoresistance glioblastoma multiforme (GBM), targeting GSCs is an attractive strategy to treat GBM. Utilizing anti-cancer compound library, we identified R406, active metabolite of FDA-approved Syk inhibitor for immune thrombocytopenia (ITP), with remarkable cytotoxicity against but not normal neural cells. R406 significantly inhibited neurosphere formation triggered apoptosis GSCs. induced metabolic...
Abnormalities in autophagy are associated with Alzheimer's disease (AD)-like lesions. Studies have shown that exercise can significantly improve AD abnormalities, but the mechanism underlying this phenomenon remains unclear. APN not only has an important regulatory effect on also is affected by exercise. Therefore, study aims to reveal pathway which regulates abnormal using APN-AdipoR1 signaling as entry point. The results of showed APP/PS1 double transgenic model mice (24 weeks) decreased...
<title>Abstract</title> This study explored the potential of a low-protein diet (LPD) to modulate gut microbiota, focusing on pancreatic ductal adenocarcinoma (PDAC) progression and response immunotherapy. A 25% reduction in dietary protein intake attenuated PDAC development, drove immune activation tumor microenvironment (TME) boosted immunostimulatory tumor-associated macrophages (TAMs) phenotype. We found depletion microbiota compromised anti-tumor effect LPD. Specifically, significant...
Hepatocellular carcinoma tumor-repopulating cells (HCC-TRCs) drive disease progression, yet their purine metabolism mechanisms remain poorly understood. This study revealed that the stemness index, strongly linked to poor HCC prognosis, exhibited a robust positive correlation with through single-sample gene set enrichment analysis (ssGSEA). Integrated drug screening across CTRP, GDSC, and PRISM databases identified alisertib, an Aurora kinase A inhibitor, as potent agent targeting stemness....
<title>Abstract</title> Typical pathological features of Alzheimer's disease include disturbances in cholesterol metabolism and defects lysosomal function the brain. With age progression, patients with have decreased synthesis brain abnormal accumulation neurons, accompanied by elevated 27-hydroxycholesterol concentrations. High-cholesterol diets are more common patients, which may promote further exacerbate disturbance This leads to entry into through blood-brain barrier, where it disrupts...
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement potency through refinement the low energy ligand conformation mitigation high in vivo clearance. An vitro hepatotoxicity hazard identified resolved lipophilicity lipophilic efficiency to arrive at GNE-616 (24), highly potent, metabolically stable, subtype selective inhibitor Nav1.7. Compound 24 showed robust...
Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of methylene (CH 2 ) spacer between alcohol moiety and carbonyl group classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability did not impair its activity against topoisomerase I (Topo I), but rather appears to improve it compared CPT. In an attempt antitumor homocamptothecins, series novel hCPT derivatives conjugating dihydropyrimidine (DHPM) was designed...