The aim of this study was to quantify the effect new Low-profile Visualized Intraluminal Support (LVIS®D) device and difference fluid diverting compared with Pipeline Enterprise stent using computational dynamics (CFD).In research, we simulated three aneurysms constructed from 3D digital subtraction angiography (DSA). Enterprise, LVIS were virtually conformed fit into vessel lumen placed across aneurysm orifice. Computational analysis performed compare hemodynamic differences such as WSS,...

Hemodynamic factors are thought to play an important role in the initiation, growth, and rupture of cerebral aneurysms. However, hemodynamic features residual neck partially embolized aneurysms their influences on recanalization rarely reported. In this study, we characterized hemodynamics occluded aneurysms, which were proven undergo during follow-up using computational fluid dynamic analysis.From May 2007 June 2009, identified 11 partial follow-up, including 5 recanalized cases 6 stable...

Background and Purpose The authors evaluated the impact of morphologic hemodynamic factors on multiple intracranial aneurysms aimed to identify which parameters can be reliable indexes as one aneurysm ruptured, others did not. Methods Between June 2011 May 2014, 69 patients harboring (69 ruptured 86 unruptured) were analyzed from 3D-digital subtraction angiography (DSA) images computational fluid dynamics (CFD). Morphologic for significance with respect rupture. Receiver operating...

Abstract In the last 30 years, there are ≈60 000 publications about electrospun nanofibers, but it is still unclear whether nanoscale fibers really necessary for tissue engineering scaffolds. The present report puts forward this argument and reveals that compared with microfibers diameter of ≈3 µm (named as “oligo‐micro fiber”) more appropriate scaffolds owing to their better cell infiltration ability caused by larger pores available nuclear deformation. To further increase pore sizes,...

The recanalization of cerebral aneurysms after endovascular embolization (coiling or stent-assisted coiling) has been a matter concern.To systematically evaluate the predisposing factors for aneurysm using multidimensional analysis in large patient cohort.In 238 patients with 283 aneurysms, baseline characteristics, morphological treatment-related factors, and changes flow hemodynamics treatment were compared between non-recanalization groups. Multivariate logistic regression was performed...

Some totally occluded intracranial aneurysms may recur. The role of hemodynamic mechanisms in this process remains to be elucidated. authors used computational fluid dynamic analysis and investigated the local characteristics at aneurysm neck before after total embolization, attempting identify risk factors leading recurrence embolized aneurysms.Between May 2008 June 2010, recruited 17 consecutive patients with (7 recanalized 10 stable lesions). Using patient-specific 3D digital subtraction...

Background and Purpose Hemodynamic factors are commonly believed to play an important role in the pathogenesis, progression, rupture of cerebral aneurysms. In this study, we aimed identify significant hemodynamic morphological parameters that discriminate intracranial aneurysm status using 3-dimensional-angiography computational fluid dynamics technology. Materials Methods 3D-DSA was performed 8 patients with mirror posterior communicating artery aneurysms (Pcom-MANs). Each pair divided into...

To identify clinical, morphological, and hemodynamic independent characteristic factors that discriminate posterior communicating artery (PCoA) aneurysm rupture status.173 patients with single PCoA aneurysms (108 ruptured, 65 unruptured) between January 2012 June 2014 were retrospectively collected. Patient-specific models based on their three-dimensional digital subtraction angiography images constructed analyzed by a computational fluid dynamic method. All variables univariate analysis...

The authors evaluated the impact of morphological and hemodynamic factors on rupture matched-pairs ruptured-unruptured intracranial aneurysms one patient's ipsilateral anterior circulation with 3D reconstruction model computational fluid dynamic method simulation. 20 patients pairs same-side but different status were retrospectively collected. Each pair was divided into group. Patient-specific models based their 3D-DSA images constructed analyzed. relative locations, morphologic these two...

Background and Purpose— The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration deployed FD. We studied resultant after implantation FDs using computational fluid dynamic simulations based micro–computed tomography reconstructions rabbit aneurysm model. Methods— images vascular model rabbit-specific angiograms 14 rabbits were reconstructed for studies, inlet waveforms used as boundary conditions. occluded...

Endovascular treatment of paraclinoid aneurysms is preferred in clinical practice. Flow alterations caused by stents and coils may affect outcome.To assess hemodynamic changes following stent-assisted coil embolization (SACE) subtotally embolized with residual necks that were predisposed to recanalization.We studied 27 (seven recanalized 20 stable) treated Enterprise stents. Computational fluid dynamic simulations performed on patient-specific aneurysm geometries using virtual stenting...

<i>Background and Purpose:</i> Intracranial aneurysms with daughter blebs appear to have a higher risk of rupture. Whether hemodynamic factors are involved in this phenomenon is not clear. <i>Methods:</i> 54 patient-specific harboring 69 were divided into ruptured unruptured groups based on their clinical history. Realistic models retrospectively constructed analyzed by computational fluid dynamic method. <i>Results:</i> There no differences the aspect...

Objective To investigate the clinical efficacy and safety of flow diverter device (FDD) in treatment tandem aneurysms internal carotid artery. Materials methods This study was a retrospectively observational involving two neurointerventional centers. Sixteen Patients with artery treated FDD Digital Subtraction Angiography (DSA) follow-up Huashan Hospital Affiliated Fudan University Jing’an District Central from 2020.08 to 2023.12 were included. The outcomes included angiographic occlusion...

In hypertension-associated arteriolosclerosis cerebral small vessel disease (CSVD), various studies have shown that MRI-detected lesions—such as lacunes, white matter hyperintensities, enlarged perivascular spaces, and microbleeds—are more prevalent in deep brain regions (DBR) than the cortex. However, underlying mechanisms remain poorly understood. We propose differential vascular remodeling between DBR vessels superficial cortical branches contributes to this heterogeneity. Using a...

This study investigates the thrombectomy performance of open (Solitaire FR 6 × 30) and closed (Trevo XP ProVue 25) stent retrievers in patient-specific vasculature using finite element analysis (FEA). The aim is to inform design optimization improve surgical strategies. Patient-specific vascular models, thrombus retriever models were constructed CAD software. FEA simulated procedure, simulation results validated through vitro experiments. predicted successful retrieval with Solitaire 30,...

This study aimed to address the compromised hemodynamics in patients with total cavopulmonary connection circulation after Fontan surgery. While procedure effectively separates systemic and pulmonary venous blood, resolving organ hypoxia, often experience complications such as elevated central pressure reduced artery (Fontan failure) due insufficient circulatory support. To improve this, a right ventricular assist device flexible impeller was designed. investigated impeller's characteristics...

Small aneurysms are usually treated with a flow diverter alone, without coils. However, some continue to exhibit incomplete occlusion after treatment, even an extended period. This study aimed investigate the effects of aneurysm morphology and location on hemodynamic parameters related poor outcomes. Two patients tandem were enrolled. Flow deployment was simulated, preoperative postoperative hemodynamics analyzed using computational fluid dynamics. The actual surgical plan simulated finite...