Curcumin (Cur) has anticancer properties but exhibits poor aqueous solubility, permeability, and photostability. In this study, we aimed to develop a solid lipid nanoparticle (SLN) system enhance Cur bioavailability. The characteristics of Cur-loaded SLNs prepared by sonication were evaluated using UV-vis Fourier transform infrared spectroscopy. mean particle size the stearic acid-based, lauric palmitic acid-based was 14.70-149.30, 502.83, 469.53 nm, respectively. chemical interactions...

Abstract Photodynamic therapy (PDT) is a promising anticancer treatment because it patient-friendly and non-invasive. Methyl pyropheophorbide-a (MPPa), one of the chlorin class photosensitizers, drug with poor aqueous solubility. The purpose this study was to synthesize MPPa develop MPPa-loaded solid lipid nanoparticles (SLNs) improved solubility PDT efficacy. synthesized confirmed 1 H nuclear magnetic resonance ( H-NMR) spectroscopy UV–Vis spectroscopy. encapsulated in SLN via hot...

Background: Postoperative adhesions are a common complication following abdominal surgery, affecting over 90% of patients and leading to significant morbidity. Current anti-adhesion strategies, such as the use physical chemical barriers, have limitations short retention time, mechanical fragility, inefficient drug delivery. This study developed pectin-based emulsion gel loaded with celecoxib prevent provide localized pain relief. Methods: Formulations (F1–F4) different pectin concentrations...

This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using phosphatidylcholine (PC)-based solid dispersion system. When fabricating PC-based dispersion, we employed mesoporous microparticles, as an adsorbent, disintegrants sticky nature PC respectively. The dispersions were prepared by solvent evaporation technique characterized Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry, X-ray powder...

Purpurin-18 (P18) is one of the essential photosensitizers used in photodynamic therapy (PDT), but its hydrophobicity causes easy coalescence and poor bioavailability. This study aimed to synthesize P18 design P18-loaded solid lipid nanoparticles (SLNs) improve The characteristics synthesized SLNs were evaluated by particle release studies. effects using 1,3-diphenylisobenzofuran (DPBF) assay as a nonbiological phototoxicity against HeLa A549 cell lines biological assay. mean size zeta...

Photodynamic therapy (PDT) is a non-invasive and tumour-specific therapy. Photosensitizers (PSs) (essential ingredients in PDT) aggregate easily owing to their lipophilic properties. The aim of this study was synthesise PS (methyl pheophorbide a, MPa) design biocompatible lipid-based nanocarrier improve its bioavailability pharmacological effects. MPa-loaded nano-transfersomes were fabricated by sonication. characteristics synthesised assessed. effects PDT evaluated 1,3-diphenylisobenzofuran...

Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial treatment biocompatible lipid-based nano-carrier enhancing permeation AD, and formulation consisting carrier incorporated in skin. AD-loaded solid lipid nanoparticles (SLNs) were prepared using double-emulsion method. Particle characteristics mechanical properties SLNs skin, respectively,...

Itraconazole (ITZ) is an anti-fungal agent generally used to treat cutaneous mycoses. For efficient delivery of ITZ the skin tissues, oil-in-water (O/W) cream formulation was developed. The O/W base designed based on solubility measurement in various excipients. A physical mixture and also prepared as a control evaluate effects solubilized state vitro deposition behavior ITZ. Polarized light microscopy differential scanning calorimetry demonstrated that fully formulation. exhibited...

Cancer is a devastating disease and major human health concern. Various combination treatments have been developed to combat cancer. To obtain superior cancer therapy, the objective of this study was synthesize purpurin-18 sodium salt (P18Na) design P18Na- doxorubicin hydrochloride (DOX)-loaded nano-transferosomes as photodynamic therapy (PDT) chemotherapy for The characteristics DOX-loaded were assessed, pharmacological efficacy P18Na DOX determined using HeLa A549 cell lines. nanodrug...

Cancer is one of the most significant threats to human health. Following surgical excision, chemotherapy an effective strategy against remaining cancer cells. 4-hexylresorcinol (4-HR) has anti-cancer properties and exhibits hydrophobicity-induced aggregation in blood that trouble with targeted tumor delivery cellular uptake drug. The purpose this study encapsulate 4-HR into solid lipid nanoparticles (SLNs) enhance its effect by avoiding facilitating uptake.

The study aimed to assess the skin hydrating effect of hydrogels containing serine‐loaded solid lipid nanoparticles (SLN) prepared with lipids having high affinity stratum corneum (SC) and polysaccharide‐rich reed ( Phragmites communis ) root extract (RRE). To select a SC, interaction between SC obtained by tape stripping technique three different such as glycerol mono‐oleate (GMO), lauric acid (LA), capric (CA) was examined ATR‐FTIR. After choosing GMO highest hydrogel formulations SLN...

In this study, we condensed methyl pyropheophorbide-a (2) with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin (3a) as an effective near-infrared photosensitizer (PS) absorption maximum of 730 nm. The ability 3a generate singlet oxygen, well its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity negligible dark toxicity. Its structure examined by UV-visible spectroscopy, nuclear magnetic resonance, high-resolution fast atom bombardment...

Herein we investigate the influence of hydrophilic polymers on buccal permeability collagen hydrolysate (CGH) by performing in vitro permeation test and viscosity measurements. After demonstrated that CGH (2000–3000 Da) could be delivered across reconstructed human tissue as evaluated hydroxyproline assay, effects different polymers, varying amounts CGH, hydration methods were examined to elucidate relationship with behavior CGH. The percentage permeated was found highest HPMC E5 solution...

Photodynamic therapy (PDT) is an innovative cancer treatment that utilizes light. When light irradiates, purpurin-18-N-propylimide methyl ester (P18 N PI ME) generates reactive oxygen species destroy cells. The hydrophobic nature of P18 ME presents challenges regarding its aggregation in the body, which can affect effectiveness. This study aimed to enhance bioavailability and effectiveness by synthesizing formulating ME-loaded solid lipid nanoparticles (SLNs). efficacy PDT was estimated...

Enhancement of skin penetration adenosine using lipid nanoparticles Appendix S1: Supporting information Figure S1 In vitro release profiles AD incorporated in LN formulations (F1-6). From the F1 to F6, it appears that AD-release rates decreased by increasing amount stearic acid and Span® 80, respectively formulations. The data are expressed as mean ± SD three independent experiments (n = 3). AD, adenosine; LN, nanoparticle. S2 Scanning electron microscopy images lyophilized AD-loaded (A)...

In the present study, a chlorin derivative photosensitizer (PS), purpurin-18 methyl ester (P18ME), and its transition metal complexes were synthesized evaluated for their in vitro photodynamic therapy (PDT) efficacy. The effect of introducing metals into free-base PS was assessed, heavy-atom two divalent metals, palladium(II) cobalt(II), compared. All exhibited hypsochormic shifts Q-bands demonstrated significantly improved photostability. addition, complex P18ME (Pd-P18ME) increased singlet...