A5043198776- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Healthcare and Venom Research
- Single-cell and spatial transcriptomics
- Mosquito-borne diseases and control
- solar cell performance optimization
- RNA modifications and cancer
- Spacecraft Design and Technology
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Reproductive Biology and Fertility
- Immune cells in cancer
- Silicon and Solar Cell Technologies
- Aquaculture disease management and microbiota
- Cancer Immunotherapy and Biomarkers
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Physiological and biochemical adaptations
- Cancer Genomics and Diagnostics
- Systems Engineering Methodologies and Applications
- Neurogenesis and neuroplasticity mechanisms
- Ovarian cancer diagnosis and treatment
- Reproductive Health and Technologies
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
New York Genome Center
2025
Cornell University
2025
Hanyang University
2017-2023
Korea Research Institute of Bioscience and Biotechnology
2023
Korea Post
2016
Dongguk University
2015
Amunix (United States)
1996-2002
Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are most prominent features of atherosclerosis. To understand pathophysiology atherosclerotic disease, we need to characteristics lipid-laden foamy macrophages in during Objective: We sought examine transcriptomic profiles nonfoamy isolated from intima. Methods Results: Single-cell RNA sequencing analysis CD45 + leukocytes murine aorta revealed that there macrophage subpopulations with...
blood cells, called hemocytes, are classified into plasmatocytes, crystal and lamellocytes based on the expression of a few marker genes cell morphologies, which inadequate to classify complete hemocyte repertoire. Here, we used single-cell RNA sequencing (scRNA-seq) map hemocytes across different inflammatory conditions in larvae. We resolved plasmatocytes states involved cycle, antimicrobial response, metabolism together with identification intermediate states. Further, discovered rare...
Abstract The Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding mechanisms underlying hematopoiesis immunity. Three types hemocytes have characterized in gland: plasmatocytes, lamellocytes, crystal cells, which are analogous to vertebrate myeloid yet molecular underpinnings gland less investigated. Here, we use single-cell RNA sequencing comprehensively analyze heterogeneity developing discover...
The advent of high-throughput RNA sequencing (RNA-seq) has led to the discovery unprecedentedly immense transcriptomes encoded by eukaryotic genomes. However, transcriptome maps are still incomplete partly because they were mostly reconstructed based on RNA-seq reads that lack their orientations (known as unstranded reads) and certain boundary information. Methods expand usability data predetermining orientation precisely determining boundaries assembled transcripts could significantly...
SUMMARY Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome directed through multiple interconnected epigenetic signals, including chromatin accessibility and histone modifications. These complex networks have been shown be disrupted during aging, disease, cancer. However, profiling these across diverse cell types states has limited due technical constraints existing methods for mapping DNA:Protein interactions in single cells. As result,...
Drosophila hemocytes serve as the primary defense system against harmful threats, allowing animals to thrive. Hemocytes are often compared vertebrate innate immune cells due observed functional similarities between two. However, have primarily been established based on a limited number of genes and their homologies. Thus, systematic analysis using transcriptomic data could offer novel insights into hemocyte function provide new perspectives evolution system. Here, we performed cross-species...
Abstract Immune class in hepatocellular carcinoma (HCC) has been shown to possess immunogenic power; however, how preestablished immune landscapes premalignant and early HCC stages impact the clinical outcomes of patients remains unexplored. We sequenced bulk transcriptomes for 62 malignant tumor samples from a Korean cohort which 38 underwent total hepatectomy, as well 15 normal 47 adjacent nontumor samples. Using silico deconvolution expression mixtures, 22 cell fractions each sample were...
Summary Drosophila blood cells, called hemocytes, are classified into plasmatocytes, crystal and lamellocytes based on the expression of a few marker genes cell morphologies, which inadequate to classify complete hemocyte repertoire. Here, we used single-cell RNA sequencing (scRNA-seq) map hemocytes across different inflammatory conditions in larvae. We resolved plasmatocytes states involved cycle, antimicrobial response, metabolism together with identification intermediate states. Further,...
SUMMARY Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and hemocytes, has been a valuable model for understanding mechanisms underlying hematopoiesis immunity. Three types mature hemocytes have characterized in gland: plasmatocytes, lamellocytes, crystal cells, which are analogous to vertebrate myeloid cells. Here, we used single-cell RNA sequencing comprehensively analyze heterogeneity developing discovered novel hemocyte types, stem-like prohemocytes,...
Objectives: To report on the result of infertility treatment with Korean medicine in clinical settings. Methods: This study was single arm, retrospective observational study. Analysis medical records thirty four infertile women who were treated by acupuncture, moxibustion, herbal medicine(Jokyungjongoktang-gagambang, Sutaehwan-gagambang). Pregnancy rate(PR) and Live birth rate(LBR) analyzed as primary outcomes. Changes AMH, FSH, LH, E2, P4, endometrial thickness, fat mass, BMI also secondary...
A silicon solar cell with AMO 19% Beginning of Life (BOL) efficiency is reported. The has demonstrated equal or better radiation resistance when compared to conventional space cells. Conventional performance generally /spl ap/14% at BOL. Radiation Hardened High Efficiency Silicon (RHHES) thinned for high specific power (watts/kilogram). RHHES provides compatibility automatic surface mounting technology. cells can be easily combined provide desired levels and voltages. more resistant...
Purpose: This study was to observe the effect of herbal decoction for sitz bath on dermoepidermal recovery wound tissue in rat's skin. Methods: The samples were assigned 3 groups: control group : without any treatment, positive potarose 10% solution, experiment bath. We made open size that cut deep into dermis. Treating 17 days, we observed diminishing. On 17th cell viability measured by MTT assay. anti-inflammatory and examined H&E staining, immunohystochemical staining MIP-2, FGF. Results:...
Abstract Single-cell RNA sequencing (scRNA-seq) has revealed important insights into the heterogeneity of malignant cells. However, sample-specific genomic alterations often confound such analysis, resulting in patient-specific clusters that are difficult to interpret. Here, we present a novel approach address issue. By normalizing gene expression variances identify universally variable genes (UVGs), were able reduce formation and underlying molecular hallmarks In contrast highly vulnerable...
The purpose of this paper is to report the progress achieved in transition-to-production radiation hardened high efficiency silicon (RHHES) solar cell first introduced 1993. RHHES has a back-junction point-contact structure which demonstrated higher than 18% AMO efficiency. Two major improvements were accomplished: a) scaling up from laboratory prototype size one suitable for space applications; b) optical matching cover glass light trapping surface. In order accommodate larger size, it was...
This paper presents the results of a project to develop back-junction, point-contact silicon solar cells and modules for space. Such are already fabricated commercially terrestrial applications using standardized equipment processes originally developed high manufacturing throughput, low-cost semiconductor chip technologies. Individual 2 cm/spl times/2 cm cell outputs 18%, AM0 routinely obtained. Since all contacting takes place at back surface, very packing densities possible resulting in...
Abstract The advent of high-throughput RNA-sequencing (RNA-seq) has led to the discovery unprecedentedly immense transcriptomes encoded by eukaryotic genomes. However, transcriptome maps are still incomplete partly because they were mostly reconstructed based on RNA-seq reads that lack their orientations (known as unstranded reads) and certain boundary information. Methods expand usability data predetermining orientation precisely determining boundaries assembled transcripts could...
Abstract Hepatocellular carcinoma (HCC), a major form of primary liver cancer, is one the leading causes cancer-related death, and caused by myriad risk factors from chronic inflammation viral infection to genetic defects. Recent investigations shed light on importance role immune cells in tumor microenvironment; however, since majority studies have focused only sites, tumor-surrounding (or precancerous) area with was not investigated HCC detail. For treatment patients, transplant (total...