A5100746129- Fibromyalgia and Chronic Fatigue Syndrome Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Drug-Induced Hepatotoxicity and Protection
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Medicinal Plants and Neuroprotection
- Health, psychology, and well-being
- Biochemical effects in animals
- Musculoskeletal pain and rehabilitation
- Food Quality and Safety Studies
- Berberine and alkaloids research
- Long-Term Effects of COVID-19
- Exercise and Physiological Responses
- Ginger and Zingiberaceae research
- Healthcare and Venom Research
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Liver Disease and Transplantation
Daejeon University
2016-2025
Daejeon Oriental Hospital
2015-2024
CHA University
2021
Dunsan Korean Medicine Hospital
2020
The present study investigated the antifatigue effects of Panax ginseng C.A. Meyer in 90 subjects (21 men and 69 women) with idiopathic chronic fatigue (ICF) a randomised, double-blind, placebo-controlled parallel designed trial. A bespoke 20% ethanol extract P. (1 g or 2 day(-1)) placebo was administered to each group for 4 weeks, then severity monitored using self-rating numeric scale (NRS) visual analogue (VAS) as primary endpoint. Serum levels reactive oxygen species (ROS),...
Abstract We evaluated the neuropharmacological effects of 30% ethanolic pine needle extract (PNE) on memory impairment caused by scopolamine injection in mice hippocampus. Mice were orally pretreated with PNE (25, 50 and 100 mg/kg) or tacrine (10 for 7 days (2 was injected intraperitoneally, 30 min before Morris water maze task first day. To evaluate function, performed 5 consecutively. Scopolamine increased escape latency cumulative path-length but decreases time spent target quadrant,...
Meteorin-like (metrnl) is a recently identified adipomyokine that beneficially affects glucose metabolism; however, its underlying mechanism of action not completely understood. We here show the level metrnl increases in vitro under electrical pulse stimulation and vivo exercised mice, suggesting secreted during muscle contractions. In addition, uptake via calcium-dependent AMPKα2 pathway skeletal cells phosphorylation HDAC5, transcriptional repressor GLUT4, an AMPKα2-dependent manner....
Sleep deficiency is a rampant issue in modern society, serving as pathogenic element contributing to learning and memory impairment, with heightened sensitivity observed children. Clinical observations suggest that disabilities associated insufficient sleep during adolescence can persist through adulthood, but experimental evidence for this lacking. In study, we examined the impact of early-life deprivation (SD) on both short-term long-term memory, tracking effects sequentially into...
Among sex hormones, estrogen is particularly well known to act as neuroprotective agent. Unlike estrogen, testosterone has not been investigated in regard its effects on the brain, especially under psychological stress. To investigate role of oxidative brain injuries stress, we adapted an orchiectomy and restraint stress model. BALB/c mice were subjected either or sham operation. After allowing 15 days for recovery, re-divided into four groups according exposure stress: sham, plus...
Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness medically unexplained, affecting approximately 1% of the global population. Due to subjective complaint, assessing exact severity fatigue clinical challenge, thus, this study aimed produce comprehensive features in ME/CFS patients. Methods We systematically extracted data for levels participants randomized controlled trials (RCTs) targeting from PubMed, Cochrane Library, Web Science, and...
Major depressive disorder (MDD) is a widespread psychiatric condition with substantial socioeconomic impacts, yet single-target pharmacotherapies often yield responses. To address its multifactorial nature, this study employed multiscale network analysis of herbs, their active components, and MDD-associated protein targets. Using biased random walk restart, we calculated interactions between disease-related herb-derived targets, identifying herbs highly correlated MDD. Enrichment further...
The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for antioxidants from 103 subjects with ICF (20 men 83 women) to those 82 healthy volunteers (27 55 women). Oxidative parameters, which included reactive oxygen species (ROS), malondialdehyde (MDA) F2-isoprotan, tumor necrosis factor-alpha (TNF-α) were significantly elevated, while antioxidant total activity (TAC), catalase,...
Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage a serious concern. Drug development for protection or reduction therefore clinical issue. Herein, we evaluated protective properties Panax ginseng Meyer and its corresponding mechanisms.C56BL/6 mice were orally pretreated with P. water extract (PGE; 25 mg/kg, 50 100 mg/kg) intraperitoneally injected melatonin (20 4 d consecutively, then exposed to 15-Gy X-ray radiation 1 h after last...
We aimed to identify the hepatoprotective effects of Terminalia chebula water extract (TCW) and its corresponding pharmacological actions using C57/BL6 mice model tert-butylhydroperoxide-(t-BHP-) induced acute liver injury. Mice were orally administered with TCW (0, 50, 100, or 200 mg/kg) gallic acid (100 for 5 days before t-BHP (2.5 mM/kg) injection. Liver enzymes, histopathology, oxidative stress parameters, antioxidant components, inflammatory cytokines examined 18 h after injection...
Chronic stress contributes to the development of brain disorders, such as neurodegenerative and psychiatric diseases. Oxidative damage is well known a causative factor for pathogenic process in tissues. The aim this study evaluate neuroprotective effect 30% ethanol extract Aquilariae Lignum (ALE) repeated stress-induced hippocampal oxidative injury.Fifty BALB/c male mice (12 weeks old) were randomly divided into five groups (n = 10). For 11 consecutive days, each group was orally...
Social isolation stress–derived depressive behavior and ethanol intake act as a vicious cycle.
Sepsis leads to multi-organ failure due aggressive systemic inflammation, which is one of the main causes death clinically. This study aimed evaluate whether ginseng sprout extracts (GSE) can rescue sepsis and explore its underlying mechanisms. C57BL/6J male mice (n = 15/group) were pre-administered with GSE (25, 50, 100 mg/kg, p.o) for 5 days, a single injection lipopolysaccharide (LPS, 30 i.p) was administered construct model. Additionally, RAW264.7 cells treated LPS with/without GSE/its...
Abstract Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date. Methods Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation implicated in the pathogenic causes of ME/CFS and associated symptoms. We experimentally evaluated this hypothesis series mouse models. Results High-dose selective serotonin reuptake inhibitor (SSRI) treatment...