A5016645872- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Vector-borne infectious diseases
- Neuroendocrine regulation and behavior
- Action Observation and Synchronization
- Infant Health and Development
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Viral Infections and Vectors
- Face Recognition and Perception
- Media Influence and Health
- Attention Deficit Hyperactivity Disorder
- Fetal and Pediatric Neurological Disorders
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Diet and metabolism studies
Centre for Addiction and Mental Health
2018-2025
Mental Health Research Institute
2020-2025
University of Toronto
2014-2025
Mental Health Research Canada
2024
Institut des Sciences Cognitives Marc Jeannerod
2021
Western University
2014-2020
Parkwood Institute
2020
University of British Columbia
2020
University of California, San Francisco
2014
Freie Universität Berlin
2014
Functional neuroimaging emerged with great promise and has provided fundamental insights into the neurobiology of schizophrenia. However, it faced challenges criticisms, most notably a lack clinical translation. This paper provides comprehensive review critical summary literature on functional neuroimaging, in particular magnetic resonance imaging (fMRI), We begin by reviewing research fMRI biomarkers schizophrenia high risk phase through historical lens, moving from case-control regional...
Background. The importance of Q fever, spotted fever group rickettsiosis (SFGR), and typhus (TGR) as causes febrile illness in sub-Saharan Africa is unknown; the putative role a human immunodeficiency virus (HIV) coinfection unclear. Methods. We identified inpatients Moshi, Tanzania, from September 2007 through August 2008 collected acute- convalescent-phase serum samples. A ≥4-fold increase immunoglobulin (Ig) G immunfluorescence assay (IFA) titer to Coxiella burnetii phase II antigen...
Coxiella burnetii is an obligate intracellular bacterium that causes the zoonotic disease Q fever. Because C. highly infectious, can survive under a variety of environmental conditions, and has been weaponized in past, it classified as select agent considered potential bioweapon. The known to be present domestic livestock wild animal populations, but background levels environment have not reported. To better understand amount United States, more than 1,600 samples were collected from six...
To determine the safety and tolerability of 3 doses intranasal oxytocin (Syntocinon; Novartis, Bern, Switzerland) administered to patients with frontotemporal dementia (FTD).We conducted a randomized, parallel-group, double-blind, placebo-controlled study using dose-escalation design test clinically feasible (24, 48, or 72 IU) twice daily for 1 week 23 behavioral variant FTD semantic (clinicaltrials.gov registration number NCT01386333). Primary outcome measures were at each dose. Secondary...
Social cognition, the perception and processing of social information, is adversely affected in multiple psychiatric, neurological, neurodevelopmental disorders, these impairments negatively impact quality life for individuals across globe. Despite clear importance efforts to advance research via harmonization data cultures diagnoses has been stymied by lack uniformly used suitable assessments. To address this issue, current study conducted an expert survey consensus process identify...
Social cognitive and neurocognitive performance is impacted in autism schizophrenia spectrum disorders (SSDs). Here, we compared social across a large transdiagnostic sample of participants with autism, SSDs, typically developing controls (TDCs). Participants (total N = 584; 100, SSDs 275, TDCs 209; aged 16-55 years; 61% male assigned at birth) completed lower-level (eg, emotion processing) higher-level theory mind) tasks, the MATRICS Consensus Cognitive Battery, measure functioning....
Empathy is crucial for successful interpersonal interactions, and it impaired in many psychiatric neurological disorders. Action-perception matching, or action simulation mechanisms, has been suggested to facilitate empathy by supporting the of perceived experience others. However, this remains unclear, involvement circuit cognitive (the ability adopt another's perspective) vs emotional capacity share react affectively experience) not quantitatively compared. Presently, healthy adults...
Abstract Background Schizophrenia spectrum disorders (SSDs) often feature social cognitive deficits. However, little work has focused on the factor structure of cognition, and results have been inconsistent in schizophrenia. This study aimed to elucidate cognition across people with SSDs healthy controls. It was hypothesized that a 2-factor model, including lower-level “simulation” higher-level “mentalizing” factors, would demonstrate best fit participants. Methods Participants (N = 164)...
Coxiella burnetii is a gram-negative bacterium that causes the zoonotic disease Q fever. Traditionally considered an obligate intracellular agent, requirement to be grown in tissue culture cells, embryonated eggs, or animal hosts has made it difficult isolate strains and perform genetic studies on C. burnetii. However, was recently demonstrated attenuated Nine Mile Phase 2 (NM2) strain will grow axenically acidified citrate cysteine medium (ACCM) 2.5% oxygen environment. The current study...
Combining data collected from multiple study sites is becoming common and advantageous to researchers increase the generalizability replicability of scientific discoveries. However, at same time, unwanted inter-scanner biases are commonly observed across neuroimaging or scanners, rendering difficulties in integrating such obtain reliable findings. While several methods for handling variations have been proposed, most them use univariate approaches that could be too simple capture all sources...
Research examining the purported association between violent gaming and aggression remains controversial due to concerns related methodology, unclear neurocognitive mechanisms, failure adequately consider role of individual differences in susceptibility. To help address these concerns, we used fMRI an emotional empathy task examine whether acute cumulative exposure were associated with abnormalities as a function trait-empathy. Emotional was targeted given its involvement regulating not only...
Abstract Functional impairments contribute to poor quality of life in schizophrenia spectrum disorders (SSD). We sought (Objective I ) define the main functional phenotypes SSD, then II identify key biopsychosocial correlates, emphasizing interpretable data-driven methods. Objective was tested on independent samples: Dataset ( N = 282) and 317), with SSD participants who underwent assessment multiple functioning areas. Participants were clustered based functioning. evaluated by identifying...
Though emotional faces preferentially reach awareness, the present study utilised both objective and subjective indices of awareness to determine whether they enhance "blindsight". Under continuous flash suppression, participants localised a disgusted, fearful or neutral face (objective index), rated their confidence (subjective index). Psychopathic traits were also measured investigate influence on emotion perception. As predicted, fear increased localisation accuracy, "blindsight" upright...
To determine whether intranasal oxytocin, alone or in combination with instructed mimicry of facial expressions, would augment neural activity patients frontotemporal dementia (FTD) brain regions associated empathy, emotion processing, and the simulation network, as indexed by blood oxygen-level dependent (BOLD) signal during fMRI. In a placebo-controlled, randomized crossover design, 28 FTD received 72 IU oxytocin placebo then completed an fMRI expression task. Oxytocin increased network...
Social cognitive impairments are core features of schizophrenia spectrum disorders (SSD) and associated with greater functional impairment decreased quality life. Metabolic disturbances have been related to in general neurocognition, but their relationship social cognition has not previously reported. In this study, metabolic measures were assessed 245 participants SSD 165 healthy comparison subjects (HC), excluding those hemoglobin A1c (HbA1c) > 6.5%. Tasks emotion processing, theory mind,...