A5076061479- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Adenosine and Purinergic Signaling
- Phagocytosis and Immune Regulation
CHA University
2019-2022
Inje University
2022
Abstract Brain inflammation is one of hypotheses explaining complex pathomechanisms depression. Angiotensin II (ANGII), which associated with hypertension, also induces brain inflammation. However, there no animal study showing the direct relationship between ANGII and To address this issue, ANGII-containing osmotic pumps were implanted into adult male C57BL/6 mice subcutaneously for subacute (7 days) chronic (at least 21 periods behavioral molecular analyses conducted. Chronic infusion...
Abstract At present, therapeutic options available for treating schizophrenia are limited to monoamine-based antipsychotic drugs. Recent genome wide association study (GWAS) indicated a close relationship between immune system and schizophrenia. To leverage the GWAS finding strategy, we conducted mechanism effect on application of human umbilical cord-derived mesenchymal stem cells (hUC-MSC) with potent immune-modulatory in an animal model useful Schizophrenia-relevant behaviors were induced...
Fetal microglia that are particularly sensitive cells to the changes in utero environment might be involved sex-biased onset and vulnerability psychiatric disorders. To address this issue, we administered a 50 µg/kg dexamethasone (DEX) dams subcutaneously from gestational days 16 18 series of behavioral assessments were performed offspring. Prenatal exposure (PN-DEX) induced schizophrenia (SCZ)-relevant behaviors male mice depressive-like behavior female mice. SCZ-relevant patterns occurred...
Abstract Background: Fetal microglia are particularly sensitive cells to the changes in utero environment and show sex-biased differences shape function. Maternal stress hormone induction can affect fetal microglial functions including alterations synaptic pruning cytokine secretion. It may contribute psychiatric outcomes offspring such as schizophrenia depression. Methods: We administered a 50 µg/kg dexamethasone (DEX) dams subcutaneously from gestational days 16 18. To characterize...
Abstract Although fluoxetine (FLX) is a commonly used drug in psychiatric disorders, such as major depressive disorder (MDD), anxiety disorder, panic and obsessive-compulsive (OCD), the mechanism by which FLX exerts its therapeutic effect not completely understood. In this study, we aimed to determine possible focuses on microglial phagocytosis. reduced phagocytic function BV2 cells increased REV-ERBα among circadian genes without affecting other microglia-related genes, inflammation did...