A5015805268- Stress Responses and Cortisol
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- Birth, Development, and Health
- Identity, Memory, and Therapy
- Health, Environment, Cognitive Aging
- Spaceflight effects on biology
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Memory and Neural Mechanisms
- Cardiac Arrest and Resuscitation
- Telomeres, Telomerase, and Senescence
- Electrolyte and hormonal disorders
- Effects of Radiation Exposure
- Mental Health Research Topics
- Dietary Effects on Health
- Genetic Associations and Epidemiology
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Stress, Anesthesia, and Immune Response
New York University
2015-2024
NYU Langone Health
2015-2020
Neurosciences Institute
2019-2020
Cohen Children's Medical Center
2014-2019
Indiana University School of Medicine
2019
VA Palo Alto Health Care System
2019
University School
2019
Background The diagnosis of posttraumatic stress disorder (PTSD) is usually based on clinical interviews or self-report measures. Both approaches are subject to under- and over-reporting symptoms. An objective test lacking. We have developed a classifier PTSD speech-marker features that discriminate cases from controls. Methods Speech samples were obtained warzone-exposed veterans, 52 with 77 controls, assessed the Clinician-Administered Scale. Individuals major depressive (MDD) excluded....
Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, limitations identifying those at risk. Prior studies suggest that PTSD may a systemic illness, affecting not just the brain, entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, organism-level physiological changes....
Abstract Active-duty Army personnel can be exposed to traumatic warzone events and are at increased risk for developing post-traumatic stress disorder (PTSD) compared with the general population. PTSD is associated high individual societal costs, but identification of predictive markers determine deployment readiness mitigation strategies not well understood. This prospective longitudinal naturalistic cohort study—the Fort Campbell Cohort study—examined value using a large multidimensional...
DNA methylation patterns at specific cytosine-phosphate-guanine (CpG) sites predictably change with age and can be used to derive "epigenetic age", an indicator of biological age, as opposed merely chronological age. A relatively new estimator, called "DNAm GrimAge", is notable for its superior predictive ability in older populations regarding numerous age-related metrics like time-to-death, time-to-coronary heart disease, time-to-cancer. PTSD associated premature mortality frequently has...
A mechanistic understanding of the pathology psychiatric disorders has been hampered by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories that are defined subjectively. We investigated whether leveraging individual differences information-processing impairments patients with post-traumatic stress disorder (PTSD) could reveal phenotypes disorder. found a subgroup PTSD from two independent cohorts displayed both aberrant functional connectivity ventral...
Genetic factors appear to be highly relevant predicting differential risk for the development of post‐traumatic stress disorder (PTSD). In a discovery sample, we conducted genome‐wide association study (GWAS) PTSD using small military cohort (Systems Biology Biomarkers Consortium; SBPBC, N = 147) that was designed as case‐controlled sample exposed, recently returning veterans with and without combat‐related PTSD. A significant single nucleotide polymorphism (SNP), rs717947, at chromosome...
The authors sought to identify brain regions whose frequency-specific, orthogonalized resting-state EEG power envelope connectivity differs between combat veterans with posttraumatic stress disorder (PTSD) and healthy combat-exposed veterans, determine the behavioral correlates of connectomic differences.The first conducted a method validation study in control subjects (N=36). They then two-site case-control without PTSD who were deployed Iraq and/or Afghanistan. Healthy individuals (N=95)...
A major challenge in understanding and treating posttraumatic stress disorder (PTSD) is its clinical heterogeneity, which likely determined by various neurobiological perturbations. This heterogeneity also reduces the effectiveness of standard group comparison approaches. The authors tested whether a statistical approach aimed at identifying individual-level neuroimaging abnormalities that are more prevalent case subjects than control could reveal new clinically meaningful insights into...
DNA methylation patterns change with age and can be used to derive an estimate of “epigenetic age,” indicator biological age. Several studies have shown associations posttraumatic stress disorder (PTSD) worse somatic health early mortality, raising the possibility accelerated aging. This study examined between estimated epigenetic various variables in 160 male combat-exposed war veterans (<i>n</i> = 79) without PTSD 81). was assessed leukocyte genomic using Illumina 450K arrays....
Abstract Post-traumatic stress disorder (PTSD) is a heterogeneous condition evidenced by the absence of objective physiological measurements applicable to all who meet criteria for as well divergent responses treatments. This study capitalized on biological diversity observed within PTSD group following epigenome-wide analysis well-characterized Discovery cohort ( N = 166) consisting 83 male combat exposed veterans with PTSD, and without in order identify patterns that might distinguish...
Posttraumatic stress disorder (PTSD) is associated with neuroendocrine alterations and metabolic abnormalities; however, how metabolism affected by disturbances unclear. The data from combat-exposed veterans PTSD show increased glycolysis to lactate flux, reduced TCA cycle impaired amino acid lipid metabolism, insulin resistance, inflammation, hypersensitive hypothalamic-pituitary-adrenal (HPA) axis. To analyze whether the co-occurrence of multiple abnormalities independent or arises an...
Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide molecular understanding PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples two cohorts well-characterized PTSD cases controls: 340 veterans 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan exposed military-service-related criterion A trauma. Molecular signatures identified from discovery cohort...
Peripheral Blood gene expression is widely used in the discovery of biomarkers and development therapeutics. Recently, a spate commercial blood collection preservation systems have been introduced with proprietary variations that may differentially impact transcriptomic profiles. Comparative analysis these platforms will help optimize protocols to detect, identify, reproducibly validate true biological variance among subjects. In current study, we tested two recently whole methods, RNAgard®...
Post-traumatic stress disorder (PTSD) is a psychiatric illness with highly polygenic architecture without large effect-size common single-nucleotide polymorphisms (SNPs). Thus, to capture substantial portion of the genetic contribution, effects from many variants need be aggregated. We investigated various aspects one such approach that has been successfully applied traits, risk score (PRS) for PTSD. Theoretical analyses indicate potential prediction ability PRS. used latest summary...
We sought to find clinical subtypes of posttraumatic stress disorder (PTSD) in veterans 6-10 years post-trauma exposure based on current symptom assessments and examine whether blood biomarkers could differentiate them. Samples were males deployed Iraq Afghanistan studied by the PTSD Systems Biology Consortium: a discovery sample 74 cases 71 healthy controls (HC), validation 26 36 HC. A machine learning method, random forests (RF), conjunction with clustering partitioning around medoids,...
Abstract Post-traumatic stress disorder (PTSD) is a mental diagnosed by clinical interviews, self-report measures and neuropsychological testing. Traumatic brain injury (TBI) can have neuropsychiatric symptoms similar to PTSD. Diagnosing PTSD TBI challenging more so for providers lacking specialized training facing time pressures in primary care other general medical settings. Diagnosis relies heavily on patient patients frequently under-report or over-report their due stigma seeking...
Dysregulation of circulating microRNAs (miRNAs) in body fluids has been reported psychiatric disorders such as schizophrenia, bipolar disorder, major depressive and post-traumatic stress disorder (PTSD). Recent studies various diseases showed that extracellular vesicles (EV) can provide different spectra miRNAs disease-associated signatures from whole fluid or EV-depleted fraction. However, the association EVs to PTSD not studied. In this study, we performed a comprehensive profiling plasma,...