A5088977905- Health, Environment, Cognitive Aging
- Stress Responses and Cortisol
- Posttraumatic Stress Disorder Research
- Anesthesia and Neurotoxicity Research
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury Research
- Gene expression and cancer classification
- Cardiovascular Health and Risk Factors
- Arctic and Antarctic ice dynamics
- Tryptophan and brain disorders
- nanoparticles nucleation surface interactions
- Spectroscopy and Quantum Chemical Studies
- Circadian rhythm and melatonin
- Advanced Chemical Physics Studies
- Machine Learning and Data Classification
- Effects of Radiation Exposure
- Telomeres, Telomerase, and Senescence
- Spaceflight effects on biology
- Statistical Methods and Inference
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Identity, Memory, and Therapy
- Climate change and permafrost
Harvard University
2016-2024
Center for Systems Biology
2016-2021
Harvard University Press
2019-2020
University of California, Santa Barbara
2015
Santa Barbara City College
2015
Johns Hopkins University
2011
Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, limitations identifying those at risk. Prior studies suggest that PTSD may a systemic illness, affecting not just the brain, entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, organism-level physiological changes....
Abstract Active-duty Army personnel can be exposed to traumatic warzone events and are at increased risk for developing post-traumatic stress disorder (PTSD) compared with the general population. PTSD is associated high individual societal costs, but identification of predictive markers determine deployment readiness mitigation strategies not well understood. This prospective longitudinal naturalistic cohort study—the Fort Campbell Cohort study—examined value using a large multidimensional...
Posttraumatic stress disorder (PTSD) is associated with impaired major domains of psychology and behavior. Individuals PTSD also have increased co-morbidity several serious medical conditions, including autoimmune diseases, cardiovascular disease, diabetes, raising the possibility that systemic pathology might be identified by metabolomic analysis blood. We sought to identify metabolites are altered in male combat veterans PTSD. In this case-control study, we compared profiles from...
Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or stress and potential novel psychological various brain, somatic, psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic disorder (PTSD), despite evidence dysfunction this condition. In the current study, we compared plasma combat trauma-exposed male veterans with PTSD (n = 111) those who did not develop 121) also investigated relationship between ccf mt-DNA glucocorticoid...
Abstract Post-traumatic stress disorder (PTSD) is a heterogeneous condition evidenced by the absence of objective physiological measurements applicable to all who meet criteria for as well divergent responses treatments. This study capitalized on biological diversity observed within PTSD group following epigenome-wide analysis well-characterized Discovery cohort ( N = 166) consisting 83 male combat exposed veterans with PTSD, and without in order identify patterns that might distinguish...
We sought to find clinical subtypes of posttraumatic stress disorder (PTSD) in veterans 6-10 years post-trauma exposure based on current symptom assessments and examine whether blood biomarkers could differentiate them. Samples were males deployed Iraq Afghanistan studied by the PTSD Systems Biology Consortium: a discovery sample 74 cases 71 healthy controls (HC), validation 26 36 HC. A machine learning method, random forests (RF), conjunction with clustering partitioning around medoids,...
Thermochemistry of gas-phase ion-water clusters together with estimates the hydration free energy and water ligands are used to calculate ion. Often calculations use a continuum model solvent. The primitive quasichemical approximation theory provides transparent framework anchor such efforts. Here we evaluate approximations inherent in approach elucidate different roles bulk medium. We find that medium can stabilize configurations cluster usually not observed gas phase, while also...
Attempts to correlate blood levels of brain-derived neurotrophic factor (BDNF) with post-traumatic stress disorder (PTSD) have provided conflicting results. Some studies found a positive association between BDNF and PTSD diagnosis symptom severity, while others the be negative. The present study investigated whether serum are different cross-sectionally combat trauma-exposed veterans without PTSD, as well longitudinal changes in differ function over time. We analyzed data 270 (230 males, 40...
Accurate classification of biological phenotypes is an essential task for medical decision making. The selection subjects classifier training and validation sets a crucial step within this task. To evaluate the impact two approaches subject selection-randomization clinical balancing, we applied six algorithms to highly replicated publicly available breast cancer data set. Using performance metrics, demonstrate that balancing improves both all methods on average. We also observed smaller...
Network-based approaches to identifying gene expression signatures of disease have been shown be more reproducible, accurate, and biologically informative than single-gene markers. Differential statistics are most commonly used rank select nodes within biological networks. Disease heterogeneity disease-specific mechanisms may create changes in distributions that not captured by differential analysis. We implemented a network identification algorithm using four unique statistical metrics,...