Silas Mann

ORCID: 0000-0003-3152-5208
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About
Contact & Profiles
Research Areas
  • Functional Brain Connectivity Studies
  • Anesthesia and Neurotoxicity Research
  • Traumatic Brain Injury Research
  • Posttraumatic Stress Disorder Research
  • Circular RNAs in diseases
  • Traumatic Brain Injury and Neurovascular Disturbances
  • MicroRNA in disease regulation
  • Neonatal and fetal brain pathology
  • Memory and Neural Mechanisms
  • RNA regulation and disease

Neurosciences Institute
2020

New York University
2017-2019

NYU Langone Health
2019

Indiana University School of Medicine
2018

University School
2017-2018

Allen Institute for Brain Science
2013

Icahn School of Medicine at Mount Sinai
2013

Rockefeller University
2013

The control of motor behavior in animals and humans requires constant adaptation neuronal networks to signals various types strengths. We found that microRNA-128 (miR-128), which is expressed adult neurons, regulates by modulating signaling excitability. miR-128 governs activity suppressing the expression ion channels components extracellular signal-regulated kinase ERK2 network regulate In mice, a reduction postnatal neurons causes increased fatal epilepsy. Overexpression attenuates...

10.1126/science.1244193 article EN Science 2013-12-05

A mechanistic understanding of the pathology psychiatric disorders has been hampered by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories that are defined subjectively. We investigated whether leveraging individual differences information-processing impairments patients with post-traumatic stress disorder (PTSD) could reveal phenotypes disorder. found a subgroup PTSD from two independent cohorts displayed both aberrant functional connectivity ventral...

10.1126/scitranslmed.aal3236 article EN Science Translational Medicine 2019-04-03

The authors sought to identify brain regions whose frequency-specific, orthogonalized resting-state EEG power envelope connectivity differs between combat veterans with posttraumatic stress disorder (PTSD) and healthy combat-exposed veterans, determine the behavioral correlates of connectomic differences.The first conducted a method validation study in control subjects (N=36). They then two-site case-control without PTSD who were deployed Iraq and/or Afghanistan. Healthy individuals (N=95)...

10.1176/appi.ajp.2019.18080911 article EN American Journal of Psychiatry 2020-01-22
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