A5016870575- Mental Health Research Topics
- Treatment of Major Depression
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychotherapy Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Obesity, Physical Activity, Diet
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Treatment and Access
- Functional Brain Connectivity Studies
- Obesity and Health Practices
- Posttraumatic Stress Disorder Research
- Schizophrenia research and treatment
- Behavioral Health and Interventions
- Personality Disorders and Psychopathology
- Impact of Technology on Adolescents
- Psychosomatic Disorders and Their Treatments
- Sexual function and dysfunction studies
- Traumatic Brain Injury Research
- Digital Mental Health Interventions
- Counseling, Therapy, and Family Dynamics
- Evolutionary Psychology and Human Behavior
- Musculoskeletal pain and rehabilitation
- Tryptophan and brain disorders
Stanford University
2011-2022
VA Palo Alto Health Care System
2015-2021
Center for Innovation
2021
Washington University in St. Louis
2020
Michigan Medicine
2020
Michigan United
2020
McLean Hospital
2020
Harvard University
2020
Neurosciences Institute
2017
Mental Illness Research, Education and Clinical Centers
2017
Patients with chronic forms of major depression are difficult to treat, and the relative efficacy medications psychotherapy is uncertain.
The development of the Emotional Eating Scale (EES) is described. factor solution replicated scale's construction, revealing Anger/Frustration, Anxiety, and Depression subscales. All three subscales correlated highly with measures binge eating, providing evidence construct validity. None EES significantly general psychopathology. With few exceptions, changes in treatment-related eating. In support measure's discriminant efficiency, when compared obese eaters, subscale scores a sample...
Theorists have proposed that depression is associated with abnormalities in the behavioral activation (BAS) and inhibition (BIS) systems. In particular, depressed individuals are hypothesized to exhibit deficient BAS overactive BIS functioning. Self-reported levels of were examined 62 participants 27 nondepressed controls. Clinical functioning was assessed at intake 8-month follow-up. Relative controls, reported lower higher levels. Within group, greater concurrent severity predicted worse...
Objectives: The objectives of this study were to provide estimates the prevalence and strength association between major depression chronic pain in a primary care population examine clinical burden associated with two conditions, singly together. Methods: A random sample Kaiser Permanente patients who visited clinic was mailed questionnaire assessing depressive disorder (MDD), pain, pain-related disability, somatic symptom severity, panic disorder, other anxiety, probable alcohol abuse,...
Despite the brain's central role in sexual function, little is known about relationships between brain activation and response. In this study, we employed functional MRI (fMRI) to examine arousal a group of young, healthy, heterosexual males. Each subject was exposed two sequences video material consisting explicitly erotic (E), relaxing (R) sports (S) segments an unpredictable order. Data on penile turgidity collected using custom-built pneumatic pressure cuff. Both traditional block...
Research has not resolved whether depression is associated with a distinct information-processing bias, the content of bias in specific to themes loss and sadness, or biases are consistent across tasks most commonly used assess attention memory processing. In present study, participants diagnosed major depression, social phobia, no Axis I disorder, completed several assessing for sad, socially threatening, physically positive stimuli. As predicted, depressed exhibited stimuli connoting...
We evaluated the association of mental illnesses with clinical outcomes among US veterans and effects Primary Care-Mental Health Integration (PCMHI).A total 4 461 208 were seen in Veterans Administration's patient-centered medical homes called Patient Aligned Care Teams (PACT) 2010 2011, whom 1 147 022 had at least diagnosis depression, posttraumatic stress disorder (PTSD), substance use (SUD), anxiety disorder, or serious illness (SMI; i.e., schizophrenia bipolar disorder). estimated 1-year...
Abstract Objective: Previous research, mostly using retrospective reports, indicated a relation of negative affect and dietary restraint with the occurrence binge episodes in eating disorder (BED). We employed Ecological Momentary Assessment (EMA) to better understand precursors consequences eating. Method: Thirty‐three females BED carried handheld computer for 7 days, were periodically prompted indicate their current emotions, hunger, status. Results: Negative mood hunger significantly...
Although many studies report that the therapeutic alliance predicts psychotherapy outcome, few exclude possibility this association is accounted for by 3rd variables, such as prior improvement and prognostically relevant patient characteristics. The authors treated 367 chronically depressed patients with cognitive-behavioral analysis system of (CBASP), alone or medication. Using mixed effects growth-curve analyses, they found early significantly predicted subsequent in depressive symptoms...
This study examined the relative effectiveness of desipramine, cognitive-behavioral therapy, and their combination in treatment bulimia nervosa, together with effects withdrawing medication after two different lengths treatment.Seventy-one patients meeting DSM-III-R criteria for recruited from an eating disorders clinic or by advertisements, were assigned at random to one five groups: desipramine (withdrawn 16 24 weeks), combined (medication withdrawn therapy (15 sessions). All treatments...
In a population sample (N=5,877; ages 15 to 54), the authors found childhood sexual and physical abuse be associated with 1-year prevalence of serious health problems for both men women. The also that participants' psychiatric disorders partially mediated effects on adult health. However, continued independently influence status after controlled disorders. Contrary expectations, individuals who experienced combination did not have higher frequency than those either type alone. Implications...
The therapeutic alliance is an established predictor of psychotherapy outcome.However, research in the treatment eating disorders has been scant, with even less attention paid to correlates development.The goal this study was examine relation between specifc patient characteristics and development 2 diferent treatments for bulimia nervosa (BN).Data derive from a large, randomized clinical trial comparing cognitive-behavioral therapy (CBT) interpersonal (IPT) BN.Across both treatments,...
This study was designed to assess the additive effects of major components cognitive-behavioral treatment for bulimia nervosa. Seventy-seven female patients with nervosa were allocated at random one four conditions: wait-list control, self-monitoring caloric intake and purging behaviors, treatment, combined response prevention vomiting. In conditions, participants seen individually fourteen 1-hr sessions over a 4-month period. All groups showed significant improvement, whereas control group...
There is growing evidence suggesting that early adversity may be a marker for distinct pathway to major depressive disorder (MDD). We examined associations between childhood and broad variety of clinical characteristics response pharmacotherapy in large sample patients with chronic forms MDD.Subjects included 808 MDD (chronic MDD, double depression, or recurrent incomplete recovery episodes total continuous duration >2 years) who were enrolled 12-week open-label trial algorithm-guided...
Little is known about moderators of response to psychotherapy, medication, and combined treatment for chronic forms major depressive disorder (MDD). We hypothesized that patient preference at baseline would interact with group differentially affect outcome.We report outcomes 429 patients who participated in a randomized multicenter trial nefazodone, Cognitive Behavioral Analysis System Psychotherapy (CBASP), or combination therapy MDD (DSM-IV criteria) indicated their type study entry. The...
This study tested whether the quality of patient-rated working alliance, measured early in treatment, predicted subsequent symptom reduction chronically depressed patients. Secondarily, assessed relationship between alliance and response to treatment differed patients receiving cognitive behavioral analysis system psychotherapy (CBASP) vs. brief supportive (BSP).
Objective: The study aims were 1) to describe the proportions of individuals who met criteria for melancholic, atypical, and anxious depressive subtypes, as well subtype combinations, in a large sample depressed outpatients, 2) compare profiles on remission change symptoms after acute treatment with one three antidepressant medications. Method: Participants 18–65 years age (N=1,008) major disorder randomly assigned 8 weeks escitalopram, sertraline, or extended-release venlafaxine. classified...
Exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD), but many patients do not respond. Brain functions governing outcome are well characterized. The authors examined brain systems relevant to emotional reactivity and regulation, constructs that thought be central PTSD exposure effects, identify the functional traits of individuals most likely benefit from treatment.Individuals with underwent MRI (fMRI) while completing three tasks assessing regulation....