A5091615989- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
- Bioinformatics and Genomic Networks
Korea University
2021-2024
Non-small cell lung cancer (NSCLC) is histologically classified into adenocarcinoma (LUAD) and squamous carcinoma (LSCC). However, some tumors are ambiguous other pathophysiological features or microenvironmental factors may be more prominent. Here we report integrative multiomics analyses using data for 229 patients from a Korean NSCLC cohort 462 previous studies. Histological examination reveals five molecular subtypes, one of which subtype with PI3K-Akt pathway upregulation, showing high...
N6-Methyladenosine (m6A) RNA modification plays a critical role in the posttranscriptional regulation of gene expression. Alterations cellular m6A levels and m6A-related genes have been reported many cancers, but whether they play oncogenic or tumor-suppressive roles is inconsistent across cancer types. We investigated common features alterations during carcinogenesis by analyzing transcriptome data 11 solid tumors from The Cancer Genome Atlas database our in-house gastric cohort. calculated...
Abstract As research into the complexities of cancer biology deepens, integration multi-omics analyses has emerged as a powerful approach to unravel complex molecular basis cancers. However, challenges related sample availability, including size, collection procedures, and storage duration, hinder broad application this methodology. Despite these limitations, there is growing interest in exploring potential archived samples expand scope research. Our study aims investigate impact duration on...
Abstract Immunotherapy holds potential as a treatment for gastric cancer (GC), though immune checkpoint inhibitor (ICI) resistance remains an obstacle. One mechanism involves defects in interferon‐γ (IFN‐γ) signaling, which IFN‐γ is linked to improved responsiveness ICIs. Herein, the roles of RNA N 6 ‐methyladenosine (m6A) modifications regulation signaling and ICIs are unveiled. The m6A‐binding protein YTH RNA‐binding F1 (YTHDF1) overexpressed GC tissues, correlating with suppression...