A5063415995- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Effects of Radiation Exposure
- PI3K/AKT/mTOR signaling in cancer
- Genomics, phytochemicals, and oxidative stress
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Biochemical Acid Research Studies
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Synthesis and Reactions of Organic Compounds
- Erythrocyte Function and Pathophysiology
- Molecular Biology Techniques and Applications
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- Bone Metabolism and Diseases
- Advanced Breast Cancer Therapies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Research and Treatments
Asan Medical Center
2012-2024
University of Ulsan
2003-2023
Ulsan College
2004-2023
Pohang University of Science and Technology
2023
Seoul National University
2005
Glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway, plays important roles in redox regulation and de novo lipogenesis. It was recently demonstrated that aberrant upregulation G6PD obese adipose tissue mediates insulin resistance as result imbalanced energy metabolism oxidative stress. remains elusive, however, whether inhibition vivo may relieve obesity-induced resistance. In this study we showed hematopoietic defect alleviates obesity,...
Background— The migration of circulating monocytes to the arterial wall during atherogenesis is largely modulated by activation CC chemokine receptor 2 (CCR2), a dominant monocyte chemotaxis receptor. present study investigated whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition affects CCR2 gene expression and CCR2-dependent recruitment. Methods Results— Competitive reverse transcription-polymerase chain reaction analysis flow cytometry showed that simvastatin, an...
Abstract Spatial manipulation of excitonic quasiparticles, such as neutral excitons, charged and interlayer in two-dimensional semiconductors offers unique capabilities for a broad range optoelectronic applications, encompassing photovoltaics, exciton-integrated circuits, quantum light-emitting systems. Nonetheless, their practical implementation is significantly restricted by the absence electrical controllability short lifetime low exciton funneling efficiency at room temperature, which...
Radiation-induced fibrosis (RIF) is one of the most common late complications radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test in vivo efficacy α-LA. α-LA suppressed expression pro-fibrotic genes after irradiation, both and vitro, inhibited up-regulation TGF-β1-mediated p300/CBP activity. Thus, radiation-induced by inhibiting transcriptional activity NF-κB through inhibition histone acetyltransferase...
// Je-won Ryu 1, * , Sung Sik Choe 2, Seung-Hee 1 Eun-Young Park Byoung Wook Lee 3 Tae Keun Kim 4 Chang Hoon Ha Sang-wook Department of Radiation Oncology, Asan Medical Center and University Ulsan College Medicine, Seoul, Republic Korea 2 Biological Sciences, Institute Molecular Biology Genetics, National Creative Research Institutive for Adipose Tissue Remodeling, Seoul University, Life Science, Natural Hallym Kyeongki Province, These authors contributed equally to this work Correspondence...
C-reactive protein (CRP) and lysophosphatidylcholine (LPC) are phosphorylcholine-(PC)-containing oxidized phospholipids (oxPLs) found in LDL (oxLDL), which trigger pro-atherogenic activities of macrophages during the process atherosclerosis. It has been previously reported that CRP binds to PC head group oxLDL a calcium-dependent manner. The aim this study was investigate importance binding between LPC macrophages.A chemiluminescent immunoassay HPLC showed human recombinant formed stable...
We hypothesized that C‐reactive protein (CRP) may affect the cell cycle and induce apoptotic changes of monocytes. CRP (∼25 μg/ml) significantly increased expressions B‐cell translocation gene 2 (BTG2) mRNA in human monocytes through pathways involving CD32/NADPH oxidase 2/p53, which eventually induced G2/M phase arrest death. Such pro‐apoptotic effect was not found thioglycollate‐elicited intraperitoneal monocytes/macrophages harvested from BTG2‐knockout male C57BL/6 mice ( n = 5). Within...
Abstract Damage to normal tissue can occur over a long period after cancer radiotherapy. Free radical by radiation initiate or accelerate chronic inflammation, which lead atherosclerosis. However, the underlying mechanisms remain unclear. Vascular smooth muscle cells (VSMCs) proliferate in response JAK/STAT3 signalling. C‐reactive protein (CRP) induce VSMCs apoptosis via triggering NADPH oxidase (NOX). Apoptotic promote instability and inflammation of atherosclerotic lesions. Herein, we...
We investigated the therapeutic effects of a mitogen-activated protein (MEK) inhibitor, selumetinib, in hepatic melanoma metastasis model and studied its possible mechanism action.Melanoma cell lines were exposed to selumetinib under different experimental conditions. established mouse liver treated mice orally with vehicle or then evaluated progress.Growth inhibition was observed cells as consequence G1-phase cell-cycle arrest subsequent induction apoptosis dose- time-dependent manner. Mice...
Tumor-derived exosomes are critical elements of the cell-cell communication response to various stimuli. This study aims reveal that histone deacetylase 5 (HDAC5) and p53 interaction upon radiation in hepatocellular carcinoma intricately regulates secretion composition exosomes. We observed HDAC5 expression were significantly increased by 2 Gy 4 exposure HCC. Normal- radiation-derived released HepG2 purified investigate exosomal components. found exosome, Maspin was notably increased. is...
Objective— The serum level of tumor necrosis factor-α (TNF-α) is in the picomolar range under inflammatory conditions. We investigated whether these levels TNF-α directly modulate functional activities circulating monocytes. Methods and Results— In THP-1 monocytes treated with (1 to 100 pmol/L/30 minutes), cytosolic RhoA small GTPase rapidly translocated plasma membrane via functionally active ezrin/radixin/moesin (ERM) complex, a cytoskeletal linker, subsequent actin polymerization through...
The CCR2 antagonist is a receptor for monocyte chemoattractant protein-1 and known to be potential anti-inflammatory therapeutic agent. Recently used optimized labeling techniques superparamagnetic iron oxide, macrophage homing, recruitment toward the infection site can observed on in vivo MRI. This study details effect of migration feasibility MRI assessing inhibition chemotactic activity by antagonist. On binding assay, inhibits affinity CCR2. Increased expression messenger ribonucleic...
<title>Abstract</title> Background Progesterone-induced blocking factor 1 (PIBF1) is linked to pregnancy-induced immunity and tumor evasion of maternal immunity. PIBF1 overexpressed in several cancers, including breast, cervical, lymphoma. However, limited research available on the role breast cancer its clinical outcomes. Therefore, we investigated relationship between expression, prognosis, impact chemotherapy response. Methods Samples from 231 patients with high-risk triple-negative...
Humanized mouse models to recapitulate human biological systems still have limitations, such as the onset of lethal graft-versus-host disease (GvHD), a variable success rate, and low accessibility total body irradiation (TBI). Recently, mice modified with CD47-SIRPA axis been studied improve humanized models. However, trials rarely applied in NOD mice. In this study, we created novel strain, NOD-CD47
In the event of a mass casualty radiation scenario, biodosimetry has potential to quantify individual exposures for triaging and providing dose-appropriate medical intervention. Structural maintenance chromosomes 1 (SMC1) is phosphorylated in response ionizing radiation. The goal this study was develop new method using SMC1 phosphorylation as measure exposure initial experiments, two normal human cell lines (WI-38VA-13 HaCaT) four lymphoblastoid were irradiated, levels at Ser-360 Ser-957...
Tumor-derived exosomes are critical elements of the cell-cell communication response to various stimuli. This study aims reveal that histone deacetylase 5 (HDAC5) and p53 interaction upon radiation in hepatocellular carcinoma intricately regulates secretion composition exosomes. Radiation doses were treated 2gy 4gy observe expression HDAC5 HCC. non-radiation released by HepG2 purified investigate exosomal components. We found radiation-derived exosome, Maspin was notably increased. In...