A5009068564- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Treatment of Major Depression
- Mental Health Research Topics
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Gut microbiota and health
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Williams Syndrome Research
- Deception detection and forensic psychology
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Intimate Partner and Family Violence
- Emotions and Moral Behavior
- Infant Development and Preterm Care
- Behavioral Health and Interventions
- Identity, Memory, and Therapy
- Transcranial Magnetic Stimulation Studies
Warneford Hospital
2015-2024
University of Oxford
2013-2024
Oxford Health NHS Foundation Trust
2019-2024
University of Minho
2011-2024
UCB Pharma (Belgium)
2023
Zogenix (United Kingdom)
2023
University College London
2023
National Health Service
2022
Oxford BioMedica (United Kingdom)
2022
Prediction error signals are fundamental to learning. Here, in mice, we show that aversive prediction found the hemodynamic responses and theta oscillations recorded from basolateral amygdala. During fear conditioning, amygdala evoked by footshock progressively decreased, whereas auditory cue predicted concomitantly increased. Unexpected larger than expected footshock. The magnitude of response behavioral following day. omission led a decrease below baseline suggesting negative signal. Thus,...
Abstract Background The potential antidepressant properties of probiotics have been suggested, but their influence on the emotional processes that may underlie this effect is unclear. Methods Depressed volunteers ( n = 71) were recruited into a randomised double-blind, placebo-controlled study to explore effects daily, 4-week intake multispecies probiotic or placebo processing and cognition. Mood, anxiety, positive negative affect, sleep, salivary cortisol serum C-reactive peptide (CRP)...
Excessive anger is linked to adverse health outcomes, including increased cardiovascular disease risk, however, its psychophysiological mechanisms are not fully understood. This study examined the effect of on autonomic nervous system activity in male participants scoring high trait anger. Participants underwent a laboratory-based induction by recalling an intensely anger-provoking event, during which heart rate variability (HRV) was recorded. The ratio low high-frequency HRV (LF/HF-HRV)...
Inhibition mediated by γ-aminobutyric acid (GABA) is implicated in motor plasticity and learning, with [GABA] the cortex decreasing during learning. However, causal relationship between learning has yet to be determined. Here, we conducted a within-subject, double-blind, placebo-controlled, crossover study investigate effect of increased GABAergic inhibition via GABAB-receptor agonist baclofen on Magnetic Resonance Spectroscopic Imaging (MRSI) metrics. Increasing GABA-mediated did not change...
Trait anxiety is associated with an excessive processing of danger-related stimuli, predisposing individuals to quickly detect threatening cues. Early, automatic mechanisms are believed be responsible for the production these cognitive biases; however, limitations in paradigms most commonly used achieve visual suppression or attentional unawareness have left open possibility strategic influencing early stages information processing. Establishing whether symptoms truly biases essential step...
Objective The aim of the present study was to evaluate effectiveness psychoeducation for bipolar I inpatients following remission a manic episode in Chinese population. Method recruited currently medicated patients, aged 18–60 years, who were from episode, as determined using Diagnostic and Statistical Manual Mental Disorders Fifth Edition ( DSM ‐5). Patients randomized (1:1) either eight sessions group‐based (active treatment group) or regular free discussions (control group). primary...
BackgroundGene association studies detect an influence of natural variation in the 5-hydroxytryptamine transporter (5-HTT) gene on multiple aspects individuality brain function, ranging from personality traits through to susceptibility psychiatric disorders such as anxiety and depression. The neural substrates these associations are unknown. Human neuroimaging suggest modulation amygdala by 5-HTT variation, but this hypothesis is controversial unresolved, difficult investigate further...
Background Fluoxetine is generally regarded as the first-line pharmacological treatment for young people, it believed to show a more favourable benefit:risk ratio than other antidepressants. However, mechanisms through which fluoxetine influences symptoms in youth have been little investigated. This study examined whether acute administration of sample healthy adults altered processing affective information, including positive, sad and anger cues. Method A total 35 male female volunteers...
Abstract Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine the antidepressant with most favourable benefit:risk ratio profile to treat adolescent depression, but neural mechanisms underlying drugs young brain are still poorly understood. Previous studies have effects long-term fluoxetine treatment depressed adolescents, these limited concurrent mood changes and a lack placebo control. There also recent evidence suggesting that reduces processing...
Minocycline has shown therapeutic promise in pre-clinical animal models and early phase clinical trials for a variety of psychiatric disorders. Previous studies on minocycline have its ability to suppress microglia activity reduce inflammatory cytokine levels, amelioration depressive-like behaviour animals humans. However, the underlying mechanisms that lead minocycline's psychotropic effects are not clear. In this study, we investigated psychological biochemical an acute dose or placebo 40...
Baclofen is a GABAB agonist prescribed as treatment for spasticity in stroke, brain injury and multiple sclerosis patients, who are often undergoing concurrent motor rehabilitation. Decreasing GABAergic inhibition key feature of learning so there possibility that GABA drugs, such baclofen, could impair these processes, potentially impacting Here, we examined the effect 10 mg 20 young healthy individuals, found drug impaired retention visuomotor with no significant on sequence learning....
Traditional paradigms for studying the unconscious processing of threatening facial expressions have methodological limitations, with most research focusing on fear, leaving important gaps in understanding anger. Using Continuous Flash Suppression (CFS), we compared emergence times angry, happy, and fearful into awareness examined their influence anger intensity after an induction protocol. Results showed that angry faces tended to break suppression faster than happy but significantly more...
Abstract Lamotrigine is an effective mood stabiliser, largely used for the management and prevention of depression in bipolar disorder. The neuropsychological mechanisms by which lamotrigine acts to relieve symptoms as well its neural effects on emotional processing remain unclear. primary objective this current study was investigate impact acute dose response a well-characterised fMRI task probing implicit relevant negative bias. 31 healthy participants were administered either single (300...
Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A agonist without antagonist activity at dopamine D2 or the 5-HT2A receptors, has demonstrated efficacy in treatment of schizophrenia. Here we report phase translational studies that profiled effect ulotaront on brain responses to reward, working memory, resting state connectivity (RSC) individuals with low high schizotypy (LS HS). Participants were randomized placebo (n = 32), (50 mg; n 30), amisulpride (400 34) 2 h...
Abstract Background Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of N-methyl-D-aspartate receptor; however, clinical evidence DCS's efficacy as a treatment for depression is limited. Other suggests DCS affects emotional learning which also be relevant and anxiety. The aim present investigation was to assess effect on processing in healthy volunteers further characterise effects autobiographical memory. Methods Forty...
Depression is a common and often recurrent illness with significant negative impact on global scale. Current antidepressants are ineffective for up to one third of people depression, many whom experience persistent symptomatology. 5-HT 4 receptor agonists show promise in both animal models depression cognitive deficit. We therefore studied the effect partial agonist prucalopride (1 mg daily 6 days) neural processing emotional faces 43 healthy participants using randomised placebo-controlled...
Abstract Background Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little known however about how current pharmacotherapies act to modulate the neural mechanisms underlying these key processes. The study therefore investigated effects fluoxetine on reactivity reappraisal adolescent depression. Methods Thirty-one adolescents MDD were randomised acute (10 mg) or placebo. Seventeen healthy also...
Activation of the glutamate N-methyl-D-aspartate receptor with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent which arises from natural breakdown host gut microbes, and predominantly sequestered pituitary. This may suggest that influences neuroendocrine stress response then impact on emotion.The current study explored effects emotional processing, cognition levels hormone cortisol volunteers.In a double-blind,...