A5036396261- CRISPR and Genetic Engineering
- Sodium Intake and Health
- Ion Transport and Channel Regulation
- Virus-based gene therapy research
- Renal and related cancers
- Urinary Tract Infections Management
- Bipolar Disorder and Treatment
- Platelet Disorders and Treatments
- Potassium and Related Disorders
- Muscle Physiology and Disorders
- Eicosanoids and Hypertension Pharmacology
- Electrolyte and hormonal disorders
- Biomedical Ethics and Regulation
- Hormonal Regulation and Hypertension
- Cell Adhesion Molecules Research
- Urinary Bladder and Prostate Research
- Aldose Reductase and Taurine
- Chronic Kidney Disease and Diabetes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Magnesium in Health and Disease
- Heparin-Induced Thrombocytopenia and Thrombosis
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Neuroendocrine regulation and behavior
Oregon Health & Science University
2023-2024
University of Portland
2022
Tokyo Medical and Dental University
2018-2021
RELX Group (United States)
2020
The sodium chloride cotransporter (NCC) has been identified as a key molecule regulating potassium balance. mechanisms of NCC regulation during low extracellular concentrations have studied in vitro. These studies shown that hyperpolarization increased efflux, leading to the activation chloride-sensitive with-no-lysine kinase (WNK) kinases and their downstream molecules, including STE20/SPS1-related proline/alanine-rich (SPAK) NCC. However, this mechanism was not vivo Previously, we...
AAV vectors show promise for gene therapy; however, kidney transfer remains challenging. Here we conduct a barcode-seq-based comparison of 47 capsids administered through different routes in mice, followed by individual validation. We find that local delivery AAV-KP1, but not AAV9, via the renal vein or pelvis effectively transduces proximal tubules with minimal off-target liver transduction, while systemic enhances tubule and podocyte transduction chronic disease. demonstrate these...
Abstract With-no-lysine (K) (WNK) kinases, which are mutated in the inherited form of hypertension pseudohypoaldosteronism type II, essential regulators membrane ion transporters. Here, we report that WNK1 positively regulates skeletal muscle cell hypertrophy via mediating function pro-longevity transcription factor forkhead box protein O4 (FOXO4) independent conventional WNK signaling pathway linking SPS/STE20-related proline-alanine–rich kinase (SPAK)/oxidative stress response 1 (OSR1) to...
Abstract Despite recent remarkable advancements in adeno-associated virus (AAV) vector technologies, effective gene delivery to the kidney remains a significant challenge. Here we show that AAV transduction proximal tubules and podocytes, crucial targets for renal therapy, can be enhanced remarkably through meticulous selection of both capsids route administration, tailored condition kidney. In this study, performed side-by-side comparison 47 using Barcode-Seq identified six capsids,...
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Abstract Background Lipid-metabolizing enzymes and their metabolites affect inflammation fibrosis, but roles in chronic kidney disease (CKD) have not been completely understood. Methods To clarify role CKD, we measured the mRNA levels of major lipid-metabolizing 5/6 nephrectomized (Nx) kidneys C57BL/6 J mice. Mediator lipidomics was performed to reveal lipid profiles CKD kidneys. Results In Nx kidneys, both protein Alox15 were higher when compared with those sham With respect situ...
Furusho, Taisuke; Galbraith-Liss, Mia S.; Sairavi, Anusha; Nakai, Hiroyuki Author Information
Nanamatsu, Azuma; Mori, Takayasu; Ando, Fumiaki; Furusho, Taisuke; Mandai, Shintaro; Susa, Koichiro; Sohara, Eisei; Rai, Tatemitsu; Uchida, Shinichi Author Information