A5019995567- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Cardiac Valve Diseases and Treatments
- Apelin-related biomedical research
- Cardiovascular Disease and Adiposity
- Renal and Vascular Pathologies
- Bone and Dental Protein Studies
- Connective tissue disorders research
- Lipoproteins and Cardiovascular Health
- Renal Diseases and Glomerulopathies
- Muscle Physiology and Disorders
- Brain Tumor Detection and Classification
- Parathyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Disease Prevention
- Cancer, Lipids, and Metabolism
Ehime University
2014-2025
University of Kentucky
2019-2024
Cardiovascular Research Center
2024
Sumitomo Hospital
2011-2012
Abstract The classical renin–angiotensin system (RAS), known as the angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages including cognitive decline. On other hand, ACE2/Ang-(1–7)/Mas axis has been highlighted exerting antagonistic actions against RAS in cardiovascular system. However, roles of function largely remain to be elucidated, and we therefore examined possible ACE2 function. Male, 10-week-old C57BL6 (wild type, WT) mice...
Hyperhomocystemia has been reported to be associated with cardiovascular disease, especially stroke. The resistive index (RI) estimated by carotid ultrasound is an established variable for estimating the risk of cerebral infarction. aim this study was evaluate relationship between homocysteine concentration and RI, a marker vascular resistance in essential hypertensive patients. We measured serum total RI 261 Multiple linear regression analysis used determine association intima media...
Background Sarcopenic obesity, age-related muscle loss, which is compensated by an increase in fat mass, impairs quality of life elderly people. Although the intramuscular associated with decreased insulin sensitivity and increased metabolic risk factors, origin diabetes-associated has not been elucidated. Here, we investigated deposition using a injury model type 2 diabetic mice. Methods Male 8-week-old C57BL/6 26-week-old KKAy underwent injection cardiotoxin (Ctx) (100 μL/10 μM) into...
Hypercholesterolemia is a well-established risk factor for kidney injury, which can lead to chronic disease (CKD). Osteopontin (OPN) has been implicated in the pathology of several renal conditions. This study was evaluate effects OPN on hypercholesterolemia induced dysfunction. Eight-week-old male mice were divided into 4 groups: apolipoprotein E knockout (ApoE(-/-)) and ApoE/OPN (ApoE(-/-)/OPN(-/-)) fed normal diet (ND) or high cholesterol (HD). After weeks, Periodic acid-Schiff (PAS) oil...
Objective: A cardinal feature of Marfan syndrome is thoracic aortic aneurysm. The contribution the renin-angiotensin system via AT1aR (Ang II [angiotensin II] receptor type 1a) to aneurysm progression remains controversial because beneficial effects angiotensin blockers have been ascribed off-target effects. This study used genetic and pharmacological modes attenuating ligand, respectively, determine their roles on in mice with fibrillin-1 haploinsufficiency ( Fbn1 C1041G/+ ). Approach...
We investigated the effects of fetal growth restriction (FGR) induced by maternal protein on inflammatory vascular remodeling using a cuff-induced injury mouse model. Dams (C57BL/6J strain mice) were fed an isocaloric diet containing 20% (normal protein; NP) or 8% (low LP) from 10 weeks age until delivery. On day delivery, all dams returned to NP diet. After weaning, offspring When age, was polyethylene cuff placement around femoral artery. Birth weight in LP delivery (LPO) significantly...
The Morris water maze test (MWM) is one of the most popular and established behavioral tests to evaluate rodents' spatial learning ability. conventional training period around 5 days, but there no clear evidence or guidelines about appropriate duration. In many cases, final outcome MWM seems predicable from previous data their trend. So, we assumed that if can predict result with high accuracy, experimental could be shortened burden on testers reduced. An artificial neural network (ANN) a...
Regular physical activity (PA), including daily walking, reduces the risk of many chronic diseases, especially hypertension. Pedometer is a potential motivational aid for increasing PA. In present study, we used telemedicine system and analyzed relationship between calculated by pedometers, blood pressure (BP).BP was measured at home twice day (morning evening) using an oscillometric automatic device. Body weight (BW) percent body fat (%BF) were after BP measurement. Daily walking steps...
Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure reduce adiposity. The clusters adipocytes that emerge with have named 'beige' or 'brite' adipocytes. Recent reports indicated the renin-angiotensin system (RAS) plays role in various aspects physiology dysfunction. biological effects angiotensin II, major component RAS, are mediated by two...
Abstract BACKGROUND Angiotensin II type 2 (AT ) receptor stimulation could exert beneficial effects on vascular remodeling. Previously, we reported that AT ameliorated insulin resistance in diabetic mice accompanied by PPARγ activation which also plays a variety of crucial roles the vasculature. Therefore, this study aimed to investigate protective effect with involving receptor-interacting protein (ATIP). METHODS AND RESULTS Vascular injury was induced polyethylene-cuff placement around...
Interleukin (IL)-18 is a member of the IL-1 family cytokines and was described originally as an interferon γ-inducing factor. Aldosterone plays central role in regulation sodium potassium homoeostasis by binding to mineralocorticoid receptor contributes kidney cardiovascular damage. has been reported induce IL-18, resulting cardiac fibrosis with induced IL-18-mediated osteopontin (OPN). We therefore hypothesized that aldosterone-induced renal via OPN may be mediated IL-18. To verify this...
Background The classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. angiotensin‐converting enzyme 2/Ang‐(1‐7)/Mas axis to exert antagonistic actions against in cardiovascular system. However, its roles brain remain unclear. We examined possible of function, employing vascular impairment model mice. Methods and Results Male 10‐week‐old C57BL6 (wild‐type mice, Mas1...
BACKGROUND: Pharmacological inhibition of megalin (also known as LRP2 [low-density lipoprotein receptor-related protein-2]) attenuates atherosclerosis in hypercholesterolemic mice. Since is abundant renal proximal tubule cells (PTCs), the purpose this study was to determine whether PTC-specific deletion reduces hypercholesterolemia-induced METHODS: Female Lrp2 f/f mice were bred with male Ndrg1 - Cre ERT2 +/0 develop PTC-LRP2 +/+ and −/− littermates. To atherosclerosis, all an LDL...
Citrus fruits are thought to have inhibitory effects on oxidative stress, thereby attenuating the onset and progression of cancer cardiovascular disease; however, there few reports assessing their effect vascular remodeling. Here, we investigated drinking juice two different citrus neointima formation using a cuff-induced injury mouse model. Male C57BL6 mice were divided into five groups as follows: 1) Control (water) (C), 2) 10% unshiu (CU) (CU10), 3) 40% CU (CU40), 4) iyo (CI) (CI10), 5)...
Introduction: Binge eating disorder (BED) is associated with dopaminergic activation as food reward, resulting in metabolism-related disorders. Stimulation of angiotensin type 2 (AT ) receptor reported to inhibit dopamine synthesis. We investigated the possible roles AT receptor-mediated regulation pathogenesis BED. Materials and methods: Male C57BL/6 mice, diabetic (KKAy) mice receptor-null KO) at eight weeks old were treated agonist, compound 21 (C21) or saline for two weeks. Mice...
Kimura's disease is a granulomatous of unknown origin that develops in the dermis, subcutaneous tissue and lymph nodes. frequently complicated by nephropathy, particularly membranous nephropathy (MN). It has recently been suggested glomerular immunoglobulin (IgG)4 deposition may play role pathogenesis idiopathic MN. These IgG4 antibodies are thought to react with antigens, primarily phospholipase A2 receptor (PLA2R) expressed on podocyte cell membrane. We herein report case MN which renal...
Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in literature has been a lack attention to sex. Also, based data with gene-deleted mice, site RAS activity that influences lesion formation is at an unknown distant location. Since angiotensin (AngII) concentrations are high kidney and major components present renal proximal tubule cells (PTCs), this study evaluated role PTCs...