A5020897950- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Aortic aneurysm repair treatments
- Cerebrovascular and genetic disorders
- Birth, Development, and Health
- MicroRNA in disease regulation
- Mechanisms of cancer metastasis
- Bone and Dental Protein Studies
- Congenital heart defects research
- Aortic Disease and Treatment Approaches
- Nuclear Receptors and Signaling
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Fatty Acid Research and Health
- Connective tissue disorders research
University of Kentucky
2021-2023
Cardiovascular Research Center
2023
Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in literature has been a lack attention to sex. Also, based data with gene-deleted mice, site RAS activity that influences lesion formation is at an unknown distant location. Since angiotensin (AngII) concentrations are high kidney and major components present renal proximal tubule cells (PTCs), this study evaluated role PTCs...
In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose this study was investigate whether fludrocortisone induces pathologies both normocholesterolemic and hypercholesterolemic mice.
Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined effects hepatocyte-specific (N-acetylgalactosamine-conjugated) antisense oligonucleotides targeting AGT (GalNAc ASO) on AngII-mediated blood pressure (BP) regulation and atherosclerosis compared its with losartan, an AngII type 1 (AT1) receptor blocker, in hypercholesterolemic mice. Eight-week-old male low-density lipoprotein (LDL) deficient mice were administered vehicle or GalNAc ASO (1, 2.5,...
The regional heterogeneity of vascular components and transcriptomes is an important determinant aortic biology. This notion has been explored in multiple mouse studies. In the present study, we examined aortas non-human primates.Aortic samples were harvested from ascending, descending, suprarenal, infrarenal regions young control monkeys adult provided with high fructose for 3 years. structure was by histological bulk RNA sequencing analyses.Immunostaining CD31 αSMA revealed that...
The regional heterogeneity of vascular components and transcriptomes is an important determinant aortic biology. This notion has been explored in multiple mouse studies. In the present study, we examined aortas nonhuman primates.
ABSTRACT BACKGROUND β-aminopropionitrile (BAPN) is a pharmacological inhibitor of lysyl oxidase and oxidase-like proteins. Administration BAPN promotes aortopathies, although there paucity data on experimental conditions to generate pathology. The objective this study was define parameters determine whether equivalent or variable aortopathies were generated throughout the aortic tree during administration in mice. METHODS administered drinking water for period ranging from 1 12 weeks....
Objective: Renin cleaving angiotensinogen to release angiotensin I is the rate-limiting step produce II. Although juxtaglomerular cells are predominant source of renin in circulation, protein also present proximal tubules. In this study, we investigated effects tubule (PTC) on development atherosclerosis hypercholesterolemic mice Approach and Result: Inducible PTC-specific deficient (PTC-renin -/-) were developed by breeding floxed with expressing Cre under control N-myc downstream regulated...