A5103240563- Bone Metabolism and Diseases
- Metastasis and carcinoma case studies
- Bipolar Disorder and Treatment
- Nuclear Receptors and Signaling
- Venous Thromboembolism Diagnosis and Management
- Orthopaedic implants and arthroplasty
- Nitric Oxide and Endothelin Effects
- Dialysis and Renal Disease Management
- Rheumatoid Arthritis Research and Therapies
- Shoulder and Clavicle Injuries
- Maternal and fetal healthcare
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Acute Kidney Injury Research
- Eicosanoids and Hypertension Pharmacology
- Shoulder Injury and Treatment
- Diabetes and associated disorders
- Natural product bioactivities and synthesis
- Vascular Procedures and Complications
- Pregnancy and preeclampsia studies
- Knee injuries and reconstruction techniques
- Celiac Disease Research and Management
- Spine and Intervertebral Disc Pathology
- Colorectal and Anal Carcinomas
- Protease and Inhibitor Mechanisms
Tottori University
2014-2022
Kisarazu Hospital
2019
Tokyo Medical and Dental University
2018
National Cerebral and Cardiovascular Center
2013
University of Occupational and Environmental Health Japan
2006
Tohoku University
2006
Kobe University
1971
Three-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are known to enhance vascular expression of endothelial (eNOS) and inducible nitric oxide synthase (iNOS). In this study, we examined whether statins also upregulate neuronal NOS (nNOS).In cultured rat aortic smooth muscle cells, treatment with atorvastatin significantly increased nNOS expression, associated activation Akt NF-kappaB. Inhibition by dominant-negative suppressed atorvastatin-induced as well...
A high prevalence of a low glomerular filtration rate (GFR) has recently been reported in patients with diabetes without albuminuria. We aimed to clarify the clinical characteristics such patients, including associations between these and atherosclerosis.We investigated correlations estimated GFR (eGFR) lipid profiles, ankle-brachial index (ABI) intima-media thickness (IMT) 450 type 2 macroalbuminuria.The renal insufficiency (RI) (GFR ＜60 mL/min/1.73 m(2)) albuminuria was 19.1%. The ABI...
Cathepsin K is expressed by osteoclasts and synovial fibroblasts degrades key components of bone cartilage. Inhibition cathepsin protease activity may be beneficial for the prevention erosion cartilage degradation in rheumatoid arthritis (RA). The collagen-induced (CIA) rat model well established studying pathology treatment RA. We investigated effect ONO-KK1-300-01, a inhibitor (CKI), on mineral density (BMD) rats with CIA. Seven-month-old female Sprague Dawley were divided into 5 groups:...
Previous acute kidney injury (AKI) is reportedly a risk factor for future preeclampsia (PE), and PE in current pregnancies may trigger the onset of AKI. In this study, we identified factors AKI among Cesarean section (CS) patients with PE.We performed retrospective study at single center. Among 4602 deliveries between January 2017 July 2018, 944 women underwent CS. Of these, 90 had hypertensive disorders during their pregnancies, 53 diagnoses 37 gestational hypertension. Medical records were...