A5055879912- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Systemic Lupus Erythematosus Research
- Angiogenesis and VEGF in Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Connective Tissue Growth Factor Research
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Renal Diseases and Glomerulopathies
- Cardiac Arrhythmias and Treatments
- Systemic Sclerosis and Related Diseases
National Cerebral and Cardiovascular Center
2016-2025
Suita Municipal Hospital
2009-2024
Osaka University
2009
Japan Anti Tuberculosis Association
2009
Kyoto University
1998-2006
Okayama University
2004
Ono Pharmaceutical (Japan)
2003
Medical Research Foundation
2001
Action on Smoking and Health
2001
Ministry of Education, Culture, Sports, Science and Technology
2001
Background— Patients with PCSK9 gene gain of function (GOF) mutations have a rare form autosomal dominant hypercholesterolemia. However, data examining their clinical characteristics and geographic distribution are lacking. Furthermore, no randomized treatment study in this population has been reported. Methods Results— We compiled GOF mutation carriers multinational retrospective, cross-sectional, observational study. then performed placebo-phase, double-blind alirocumab 150 mg administered...
Connective tissue growth factor (CTGF) is one of the candidate factors mediating downstream events transforming factor-β (TGF-β), but its role in fibrogenic properties TGF-β and tubulointerstitial fibrosis has not yet been clarified. Using unilateral ureteral obstruction (UUO) rats, we analyzed gene expression TGF-β1, CTGF, fibronectin. We further investigated effect blockade endogenous CTGF on TGF-β-induced fibronectin cultured rat renal fibroblasts by antisense oligodeoxynucleotide (ODN)...
Aim: The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events patients with type 2 diabetes were little known on randomized controlled trial.Methods: Thirty-eight diabetic (21 men 17 women) assigned either the group (n=21) or control without training (n=17) by simple randomization. was scheduled for aerobic resistance programs 3 months. After 3-month, we investigated endothelial function, insulin resistance, adipocytokines...
Chronic kidney disease (CKD) is increasingly recognized as an independent risk factor for stroke and myocardial infarction (MI). Few studies, however, have examined the relationship between blood pressure (BP) category these diseases in subjects with without CKD.We studied 5494 Japanese individuals (ages 30 to 79, or MI at baseline) who completed a baseline survey received follow-up through December 2005. The glomerular filtration rate (GFR) was estimated using Modification of Diet Renal...
ABSTRACT. Local production of prostaglandins (PGs) in the kidney is increased clinical and experimental diabetic nephropathy, but role PGs pathogenesis progression nephropathy has remained unclear. It here shown that an orally active antagonist selective for PGE receptor EP1 subtype potently prevents streptozotocin-induced rats. The effects are by ameliorated renal glomerular hypertrophy, decreased mesangial expansion, inhibited transcriptional activation transforming growth factor-β (TGF-β)...
Glomerular injury plays a pivotal role in the development of diabetic nephropathy. To elucidate molecular mechanisms underlying glomerulopathy, we compared glomerular gene expression profiles db/db mice with those db/m control at normoalbuminuric stage characterized by hyperglycemia and an early nephropathy elevated albuminuria, using cDNA microarray. In stage, hypoxia-inducible factor-1alpha (HIF-1alpha), ephrin B2, epithelial protein 1, Pod-1, which play key roles glomerulogenesis, were...
Familial hypercholesterolemia (FH) patients are at particular risk for premature coronary artery disease (CAD) caused by high levels of low density lipoprotein (LDL). Administration statins enabled us to reduce LDL-C in heterozygous FH patients. To evaluate the impact on clinical fate FH, a retrospective study was performed.We analyzed influence age first onset CAD 329 consecutive referred lipid clinic National Cardiovascular Center. Among patients, identified 101.The 58.8+/-12.5 years 25...
Proprotein convertase subtilisin/kexin 9 (PCSK9) is known to be a good target decrease LDL cholesterol (LDL-C) and two forms of PCSK9, mature furin-cleaved circulate in blood. However, it has not been clarified whether how the levels each PCSK9 are affected by LDL-apheresis (LDL-A) treatment, standard therapy patients with severe familial hypercholesterolemia (FH).Our objective was investigate differences LDL-A-induced reduction between homozygous heterozygous FH, dextran sulfate (DS)...
Visceral fat area (VFA) is a good surrogate marker of obesity-related disorders, such as hypertension, dyslipidemia and glucose intolerance. Although estimating the VFA by X-ray computed tomography (CT) primary index for visceral obesity, it expensive requires invasive radiation exposure. Dual bioelectrical impedance analysis (BIA) simple reliable method to estimate VFA; however, clinical usefulness dual BIA remains unclear in patients with type 2 diabetes (T2D).We estimated VFAs CT 98 T2D...
Abstract Most of the diseases for which apheresis therapy is indicated are intractable and rare, each patient has a different background treatment course prior to initiation. Therefore, it difficult conduct large‐scale randomized controlled trials secure high‐quality evidence. Under such circumstances, American Society Apheresis (ASFA) issued its guidelines in 2007, were repeatedly revised until latest edition 2019. The ASFA comprehensive. However, United States, centrifugal separation...
The purpose of this study was to examine the relationships between glucose parameters obtained by continuous monitoring and clinical outcomes in acute stroke patients.
ABSTRACT. One of major causes end-stage renal disease is glomerulonephritis, the treatment which remains difficult clinically. It has already been shown that transgenic mice overexpress brain natriuretic peptide (BNP), with a potent vasorelaxing and property, have ameliorated glomerular injury after subtotal nephrectomy. However, role peptides in immune-mediated still unknown. Therefore, effects chronic excess BNP on anti-glomerular basement membrane nephritis induced BNP-transgenic (BNP-Tg)...
Abstract. Brain natriuretic peptide (BNP) is a cardiac hormone produced by the ventricle, and its secretion markedly increased in heart failure, hypertension, renal failure. Transgenic mice that overexpress BNP liver (BNP-Tg) were recently generated, resulting low BP. To elucidate role of pathophysiology, effect chronic excess transgenic on glomerular injury after subtotal nephrectomy induced resection poles was examined. After nephrectomy, cross-sectional areas control nontransgenic as...
The inverse association between plasma B-type natriuretic peptide (BNP) levels and body mass index (BMI) has been reported in Western populations. Here we analyzed the relationship BNP obesity a general urban Japanese population. We recruited 1,759 subjects without atrial fibrillation or history of ischemic heart disease aged 38-95 years (mean age +/- standard deviation 64.5 10.9 years, 56.1% women, mean BMI 22.8 3.1 kg/m(2)) from participants Suita Study August 2002 December 2003. In...
One of the major causes end-stage renal diseases is hypertensive disease, in which enhanced prostaglandin (PG) E 2 production has been shown. PGE , a arachidonic acid metabolite produced kidney, acts on 4 receptor subtypes, EP 1 through but pathophysiological importance /EP subtypes development injury remains to be elucidated. In this study, we investigated whether an orally active -selective antagonist (EP A) prevents progression damage stroke-prone spontaneously rats (SHRSP), model human...
Evidence has emerged that undernutrition in utero is a risk factor for cardiovascular disorders adulthood, along with genetic and environmental factors. Recently, the local expression of angiotensinogen related bioactive substances been demonstrated to play pivotal role cardiac remodeling, i.e. fibrosis hypertrophy. The aim present study was clarify possible involvement angiotensin system fetal undernutrition-induced disorders. We developed mouse model by maternal food restriction, which...
A high prevalence of a low glomerular filtration rate (GFR) has recently been reported in patients with diabetes without albuminuria. We aimed to clarify the clinical characteristics such patients, including associations between these and atherosclerosis.We investigated correlations estimated GFR (eGFR) lipid profiles, ankle-brachial index (ABI) intima-media thickness (IMT) 450 type 2 macroalbuminuria.The renal insufficiency (RI) (GFR ＜60 mL/min/1.73 m(2)) albuminuria was 19.1%. The ABI...
Abstract The endogenous peptide C-type natriuretic (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the of visceral adipose tissue have recently been reported to play a role lipid metabolism inflammation, we investigated effects CNP on features obesity using transgenic (Tg) mice which was placed under control Tie2 promoter thus overexpressed (E-CNP). Here show that increased brown thermogenesis E-CNP Tg energy expenditure,...