A5042936378- Circadian rhythm and melatonin
- Dietary Effects on Health
- Sleep and related disorders
- Sleep and Wakefulness Research
- Spaceflight effects on biology
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Photoreceptor and optogenetics research
- Genetics, Aging, and Longevity in Model Organisms
- Nutritional Studies and Diet
- Neuroendocrine regulation and behavior
- Psychological and Temporal Perspectives Research
- Light effects on plants
- Genetic Neurodegenerative Diseases
- Physical Activity and Health
- Adipose Tissue and Metabolism
- Allergic Rhinitis and Sensitization
- Muscle metabolism and nutrition
- Diet, Metabolism, and Disease
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Bioactive Compounds in Plants
- Medicinal Plant Research
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
Hiroshima University
2022-2024
Waseda University
2015-2024
University of California, Los Angeles
2012-2021
Neurobehavioral Systems
2017-2021
Shinjuku College of Information Technology
2021
Kyushu University
2016
Tokyo University of Science
2010
Abstract Microbiota-derived short-chain fatty acids (SCFAs) and organic produced by the fermentation of non-digestible fibre can communicate from microbiome to host tissues modulate homeostasis in mammals. The has circadian rhythmicity helps clock function. We investigated effect SCFA or fibre-containing diets on phase adjustment mouse peripheral (liver, kidney, submandibular gland). Initially, caecal concentrations, particularly acetate butyrate, induced significant day-night differences at...
Abstract The effects of acute stress on the peripheral circadian system are not well understood in vivo . Here, we show that sub-acute caused by restraint or social defeat potently altered clock gene expression tissues mice. In these tissues, as hippocampus and cortex, stressful stimuli induced time-of-day-dependent phase-advances -delays rhythmic patterns; however, such changes were observed suprachiasmatic nucleus, i.e. central clock. Moreover, several days exposure at beginning light...
The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood those light entrainment. To elucidate first step liver clock, we identified gene(s) that show phase advance acute change gene expression during early term daytime refeeding schedule in mice. expressions Per2 Rev-erbα genes were phase-advanced within 1 day refeeding. Additionally, upregulation mRNA...
Abstract Exercise during the inactive period can entrain locomotor activity and peripheral circadian clock rhythm in mice; however, mechanisms underlying this entrainment are yet to be elucidated. Here, we showed that bioluminescence of clocks PER2::LUC mice was strongly entrained by forced treadmill wheel-running exercise rather than voluntary at middle time inactivity period. Exercise-induced accompanied increased levels serum corticosterone norepinephrine tissues, similar physical...
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the digestive tract and closely associated with homeostasis gut microbiota. Inulin, as natural prebiotic, displays anti-inflammatory activity maintains equilibrium intestinal In this study, our research aimed to explore potential inulin in enhancing immunity reducing inflammation stress-recurrent IBD. co-culture epithelium model IBD mouse was used examine protective effects inulin. It observed that digesta significantly...
Peripheral circadian clocks in mammals are strongly entrained by light-dark and eating cycles. Their physiological functions maintained the synchronization of phase organs via clock gene expression patterns. However, little is known about adaptation peripheral to timing multiple daily meals. Here, we investigated effect irregular patterns, terms volume, on their vivo. We found that was altered amount food interval between feeding time points but unaffected frequency feeding, as long remained...
The peripheral circadian clock in mice is entrained not only by light-dark cycles but also daily restricted feeding schedules. Behavioral and cell culture experiments suggest an increase glucose level as a factor such feeding-induced entrainment. For application of entrainment humans, nutrient content dietary variations should be considered.To elucidate the food composition necessary for entrainment, we examined whether complete or partial substitution nutrients affected phase shifts liver...
Flavonoids are natural polyphenols that widely found in plants. The effects of flavonoids on obesity and numerous diseases such as cancer, diabetes, Alzheimer's have been well studied. However, little is known about the relationships between circadian clock. In this study, we show continuous or transient application to culture medium embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications clock amplitude, period, phase. Transient some tested cultured cells...
The meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and effects better protein on muscle volume are largely unknown. Here, using two-meals-per-day feeding model, we find that intake at early active phase promotes overloading-induced hypertrophy, in a manner dependent local clock. Mice fed branched-chain amino acid (BCAA)-supplemented diets demonstrate skeletal hypertrophy. distribution-dependent not observed Clock
Although the circadian liver clock is entrained by feeding cycle, factors such as food volume and starvation interval are poorly understood. Per2::Luc knock-in mice were given two meals per day with different sizes and/or intervals of between mealtimes total fixed at 3.6 g (80 pellets, ∼75% free feeding) mouse. The bioluminescence rhythm in produced a unimodal peak but not bimodal under regimen over 14-15 days. Peak Per2 expression occurred concurrently mealtime larger volume, when first...
Article: Differential roles of breakfast only (one meal per day) and a bigger with small dinner (two meals in mice fed high-fat diet regard to induced obesity lipid metabolism
Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian modifies phase changes in SCN-operated rhythms, effects on phase, period amplitude organ are not known. In addition, role cAMP/Ca(2+) signalling rhythm has been fully elucidated.We examined whether chronic or transient application affects period/amplitude by evaluating bioluminescence...
To determine the effects of a [6]-gingerol analogue (6G), major chemical component ginger rhizome, and its stable after digestion in simulated gastric fluid, aza-[6]-gingerol (A6G), on diet-induced body fat accumulation, we synthesized 6G A6G. Mice were fed either control regular rodent chow, high-fat diet (HFD), or HFD supplemented with Magnetic resonance imaging adiposity parameters 6G- A6G-treated mice compared those mice. Supplementation A6G significantly reduced weight gain, circulating...
We propose a method to improve the enhanced permeability and retention (EPR) effect of nanomedicines based on tumor-specific vasodilation using nitric oxide (NO) donor-containing liposome. NONOate, typical NO donor, was incorporated into PEGylated liposome retard protonation-induced release from NONOate by protecting lipid bilayer membrane. The NONOate-containing (NONOate-LP) showed similar blood an empty but almost twice amount accumulated within tumor. This improvement in EPR is thought...
The ability of the circadian clock to adapt environmental changes is critical for maintaining homeostasis, preventing disease, and limiting detrimental effects aging. To date, little known about age-related in entrainment peripheral clocks external cues. We therefore evaluated kidney, liver, submandibular gland be entrained by stimuli including light, food, stress, exercise young versus aged mice using vivo bioluminescence monitoring. Despite a decline locomotor activity, exhibited normal...