A5002122472- Circadian rhythm and melatonin
- Dietary Effects on Health
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Muscle metabolism and nutrition
- Spaceflight effects on biology
- Pharmacological Effects and Toxicity Studies
- Exercise and Physiological Responses
- Neurological and metabolic disorders
- Biochemical and Molecular Research
- Nutrition and Health in Aging
- Mitochondrial Function and Pathology
- Epilepsy research and treatment
- Dialysis and Renal Disease Management
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Muscle Physiology and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Coffee research and impacts
- Lipid metabolism and disorders
- Vehicle Noise and Vibration Control
- Psychological and Temporal Perspectives Research
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
Waseda University
2003-2021
Nagasaki University
2020-2021
The University of Tokyo
2014-2016
Tokyo Institute of Technology
2000
Nagoya University
1965
We examined the effects of meal timing on postprandial glucose metabolism, including incretin response and metabolites in healthy adults. Nineteen young men completed two trials involving blood collection a fasting state at 30, 60 120 min after provision random order: (1) morning (~0900 h) (2) evening (~1700 h). The metabolome eight participants was analyzed using capillary electrophoresis-mass spectrometry. Postprandial concentrations (p = 0.030) glucose-dependent insulinotropic polypeptide...
The meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and effects better protein on muscle volume are largely unknown. Here, using two-meals-per-day feeding model, we find that intake at early active phase promotes overloading-induced hypertrophy, in a manner dependent local clock. Mice fed branched-chain amino acid (BCAA)-supplemented diets demonstrate skeletal hypertrophy. distribution-dependent not observed Clock
Abstract Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification crucial part of disease management. Okara sustainable source fibre-rich food. Most the valorization research on okara focused more physical attributes instead possible health attributes. The fermentation using microbes originated from food source, such as tea, sake, sufu yoghurt, were explored here. aim this study to investigate fermented functional ingredient reduce blood glucose levels. Fermented...
Many genes are known to be involved in gonadal differentiation vertebrates. <i>Dmrt1</i>, a gene that encodes transcription factor with DM-domain, is considered one of the essential controlling testicular mammals, birds, reptiles, amphibians and fish. However, it still remains unknown which cells animals other than mice chicks express Dmrt1 protein. For an explanation its role(s) vertebrates, expression protein needs studied. this purpose, we conducted immunohistochemical study...
The effects of L-carnitine on the hemodynamic state chronic hemodialysis patients have been debated. In order to clarify effect administered cardiac function and hypotensive episodes during procedure, a randomized double-blind placebo-controlled study was performed for 3 months.TWENTY STABLE OUTPATIENTS UNDERGOING HEMODIALYSIS TREATMENT WERE DIVIDED INTO TWO GROUPS: controls (placebo) treated (L-carnitine 900 mg p.o. daily). After months, reevaluated by echocardiography, were assessed. Free...
The Endoscopic Surgical Skill Qualification System (ESSQS) in Japan evaluates the surgical skills required for laparoscopic surgery as an operator well a supervisor. This study aimed to demonstrate benefits of ESSQS-certified surgeon's participation rectal resections supervisor (assistant or advisor).We retrospectively reviewed resection results cStage II and III cancer performed at 56 Japanese hospitals between 2014 2016. We used propensity score matching generate paired cohorts with...
Background: Genistein has high estrogenic activity. Previous studies have shown beneficial effects of estrogen or hormone replacement therapy on muscle mass and atrophy. Objective: We investigated the preventive underlying mechanisms genistein Methods: In Expt. 1, male Wistar rats were fed a diet containing no [control (CON)] 0.05% (GEN; wt:wt diet) for 24 d. On day 14, sciatic nerve in left hind leg was severed, right sham-treated. 2, C57BL6J mice subcutaneously administered vehicle (Veh...
The mammalian circadian system is controlled not only by the suprachiasmatic nucleus (SCN), but also peripheral clocks located in tissues such as liver, kidney, small intestine, and colon, mediated through signals hormones. Peripheral clocks, SCN, can be entrained food intake schedules. While it known that cell proliferation exhibits a rhythm colon epithelium, unclear how this influenced Here, we aimed to determine relationships between feeding schedules epithelium means of immunochemical...
BackgroundAtrogin1, which is one of the key genes for promotion muscle atrophy, exhibits day-night variation. However, its mechanism and role variation are largely unknown in a atrophic context.MethodsThe mice were induced atrophy by hindlimb-unloading (HU). To examine circadian clock, Wild-type (WT) Clock mutant used. test effects neuronal effects, an unilateral ablation sciatic nerve was performed HU mice. timing-dependent weight-bearing, released from 4 h day at early or late active phase...
<b><i>Background:</i></b> It is well known that the physical activity in chronic hemodialysis patients decreases compared to normal subjects. In order investigate effects of <smlcap>L</smlcap>-carnitine on capacity and lipid metabolism, a cardiopulmonary exercise test using bicycle ergometer was performed before after 3 months oral supplementation under double-blind conditions. <b><i>Methods Results:</i></b> A total 20 stable...
<b><i>Background:</i></b> The therapeutic role of <smlcap>L</smlcap>-carnitine (LC) on the anemia chronic hemodialized patients is still controversial. In order to clarify long-term effects LC administration renal anemia, an open, observational 12-month study was performed. <b><i>Methods:</i></b> Twenty stable outpatients undergoing hemodialysis were administered 900 mg p.o. daily for 12 months. recombinant human erythropoietin...
Dietary protein intake is important for skeletal muscle synthesis.In this study, we investigated the differential effect of sources on hypertrophy plantaris induced by surgical ablation gastrocnemius and soleus muscles.Six-week old mice were fed diets containing caseinate, whey, or soy as 2 weeks.Plantaris was a unilateral synergistic muscles after week.Food protein-fed higher than that caseinate whey-fed mice, resulting in body fat weights.Plantaris weight sham-operated not different across...
Muscle mass is controlled by the balance between muscle synthesis and degradation. Although nutrition important for maintenance of growth, effects feeding time have remained unclear. In present study, we aimed to evaluate day- or night-time-restricted on volume using atrophy hypertrophy mouse models. The was conducted from zeitgeber 2 (ZT2) ZT10 ZT14 ZT22, respectively. unilateral immobilization-induced model, decrease in immobilized weight did not significantly change with time. However,...
Meal distribution of protein throughout the day is usually skewed. However, its physiological implications and effects better on muscle volume are largely unknown. Here, using two-meal-per-day-feeding model, we found that intake at early active phase, according to circadian clock, promoted overloading-induced hypertrophy. We mice were fed branched chain amino acid (BCAA)-supplemented diets phase demonstrated skeletal distribution-dependent not observed in ClockΔ19 mice. Additionally,...
第4次循環器疾患基礎調査 (平成2年実施) 成績より, 30歳以上の対象8,063人 (平均年齢52.4±14.1歳) の耐糖能異常者の頻度を問診, 随時血糖, 尿糖およびHbA1cより判定した. 耐糖能異常者の頻度は男性11.9%, 女性6.3%, 全体では8.6%であり, 高齢になるほどその頻度は増加し, 65歳以上の高齢者群では65歳未満の非高齢者群に比べ男性で約1.7倍, 女性で約2.5倍の頻度であった. また, いずれの年代でも男性の耐糖能異常者の頻度が大であり, 40歳代以上で有意となった.居住地域別では, 男性大都市居住者で耐糖能異常の頻度が郡部町村に比して有意に多かった. 男性では肥満者および日常生活活動度が低い者で耐糖能異常者の頻度が高かった. 都市住民では町村住民に比べ日常生活活動度が低い者の頻度が高く, 男性における耐糖能異常者頻度の地域差の原因として, 日常生活活動度の違いが関与している可能性が窺われた.糖尿病の一次予防として, 余暇を含め生活活動度を高めることが重要であると考えられた.