A5013024516- Circadian rhythm and melatonin
- Medical Imaging and Pathology Studies
- Dietary Effects on Health
- Receptor Mechanisms and Signaling
- Plasma Diagnostics and Applications
- Electrohydrodynamics and Fluid Dynamics
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Sleep and Wakefulness Research
- Pharmacological Effects and Assays
- Neurobiology and Insect Physiology Research
- Endoplasmic Reticulum Stress and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Veterinary medicine and infectious diseases
- Sleep and related disorders
- Electromagnetic Fields and Biological Effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heat shock proteins research
- Neurotransmitter Receptor Influence on Behavior
- Fatty Acid Research and Health
- Helicobacter pylori-related gastroenterology studies
- Fibroblast Growth Factor Research
- COVID-19 Clinical Research Studies
- Veterinary Pharmacology and Anesthesia
- Plasma and Flow Control in Aerodynamics
The University of Tokyo
2007-2023
Sapporo Medical University
2006-2020
Waseda University
1998-2018
Nagoya University
2014
University of Tsukuba
2014
Tottori University
2012-2013
Taisho Pharmaceutical (Japan)
2005
University of North Carolina at Chapel Hill
1989
In mammals, the environmental light/dark cycle strongly synchronizes circadian clock within suprachiasmatic nuclei (SCN) to 24 hr. It is well known that not only photic but also nonphotic stimuli can entrain SCN clock. Actually, many studies have shown a daytime injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT), serotonin 1A/7 receptor agonist, as stimulus induces phase advances in hamster behavioral rhythms vivo, neuron activity rhythm vitro. Recent reports suggest mammalian...
The pathogenesis of severe acute respiratory syndrome (SARS) is poorly understood and cytokine dysregulation has been suggested as one relevant mechanism to be explored. We compared the profile in Caco2 cells after infection SARS coronavirus (SARS-CoV) with other viruses including syncytial virus (RSV), influenza A (FluAV), human parainfluenza type 2 (hPIV2). Interferon (IFN) system (production response) was not suppressed by SARS-CoV infection. Therefore, replication pretreatment IFN. RSV...
The effects of repetitive laser-pulse energy depositions (5.5 mJ/pulse) onto a shock wave-boundary layer interaction region over cylinder-flare model in Mach 1.92 flow are experimentally investigated. Depending on the nose shape and flare angle, patterns subdivided to two; separated which slip line strong separation wave originated nose-cylinder junction appears, non-separated is not observed re-attachment much weaker. At angles around 30°, can be suppressed by laser deposition even down 5...
Stress induces secretion of corticosterone through activation the hypothalamic-pituitary-adrenal axis. This is thought to be controlled by a circadian clock in suprachiasmatic nucleus (SCN). The hypothalamic paraventricular (PVN) receives convergent information from both stress and clock. Recent reports demonstrate that mammalian orthologs (Per1, Per2, Per3) Drosophila gene Period are expressed SCN, PVN, peripheral tissues. In this experiment, we examined effect physical inflammatory...
Immediate-type skin allergic reactions, such as passive cutaneous anaphylactic reaction, are associated with circadian rhythm, but the role of mechanisms on delayed-type contact hypersensitivity (CHS), remains uncertain. In mice, CHS, a T-cell-mediated immune response, is classic model human dermatitis. We investigated whether biological clock dysfunction affects CHS pathogenesis in CLOCK mutant mice compared wild-type (WT) mice. Mice were treated 2,4,6-trinitro-1-chlorobenzene (TNCB)...
A two-dimensional dual pendulum thrust stand was developed to measure vectors [axial and horizontal (transverse) direction thrusts] of a Hall thruster. thruster with steering mechanism is mounted on the inner pendulum, measured from displacement between outer pendulums, by which thermal drift effect canceled out. Two crossover knife-edges support each arm: one set other at right angle. They enable pendulums swing in two directions. Thrust calibration using pulley weight system showed that...
Serotonergic projections from the midbrain raphe nuclei to suprachiasmatic (SCN) are known regulate photic entrainment of circadian clocks. However, it is not which 5‐hydroxytryptamine (5‐HT) receptor subtypes involved in regulation. In order verify role 5‐HT 1A receptors, we examined effects 5‐{3‐[((2S)‐1,4‐benzodioxan‐2‐ylmethyl)amino]propoxy}‐1,3‐benzodioxole HCl (MKC‐242), a selective agonist, on wheel‐running rhythms hamsters. MKC‐242 (3 mg kg −1 , i.p.) significantly accelerated...
The electrostatic acceleration of helicon plasma is investigated using an potential exerted between the ring anode at source exit and off-axis hollow cathode in downstream region. In region, magnetic field for source, which generated by a solenoid coil, modified permanent magnets yoke, forming almost field-free region surrounded annular cusp field. Using retarding analyzer, two primary ion energy peaks, where lower peak corresponds to space higher one beam, are detected argon as working gas...
Although fasting induces hepatic triglyceride (TG) accumulation in both rodents and humans, little is known about the underlying mechanism. Because parasympathetic nervous system activity tends to attenuate secretion of very-low-density-lipoprotein-triglyceride (VLDL-TG) increase TG stores liver, serum cholinesterase elevated fatty liver disease, inhibition neurotransmitter acetylcholinesterase (AChE) may have some influence on lipid metabolism. To assess AChE metabolism, effect...
In this study we have examined the ability of beta-adrenergic agonist isoproterenol (ISO) to alter expression human MHC class II Ag, DR, on a glioblastoma multiforme cell line. We determined that ISO induces an increase in both DR alpha-specific RNA and protein. This induction is most likely due cAMP levels elicited by agonist, based direct measurements DBcAMP adenylate cyclase activator, forskolin mimic effects isoproterenol. Blocking was achieved with beta-antagonist, propranolol, but not...
The synthesis and biological evaluation of analogues uridylpeptide antibiotics were described, the molecular interaction between 3′-hydroxy analogue mureidomycin A (3′-hydroxymureidomycin A) its target enzyme, phospho-MurNAc-pentapeptide transferase (MraY), was analyzed in detail. structure–activity relationship (SAR) involving MraY inhibition suggests that side chain at urea-dipeptide moiety does not affect inhibition. However, anti-Pseudomonas aeruginosa activity is great contrast motif a...
7545 Background: Although the overall incidence of BM is not known, bone metastases are a frequent complication in pts with advanced lung cancer. Bone can be associated SREs, which include pathologic fracture, need for surgery or radiation to bone, spinal cord compression, and hypercalcemia malignancy. The aim our study investigate prospectively BM, types time interval between influence SREs on QOL, predictive factor SREs. Methods: Eligibility criteria enrolment were newly diagnosed pt stage...
Abstract Geranylgeranylacetone (GGA) is used to treat patients suffering from peptic ulcers and gastritis. We examined the effect of GGA on Helicobacter pylori , which a causative factor gastrointestinal diseases. Previously, we have reported that binds specifically molecular chaperone HSP70. In this paper, report bounds H. HSP70 (product DnaK gene) with 26-times higher affinity than human induced large conformational changes as observed surface plasmon resonance circular dichroism. Binding...
Abstract Objective —To investigate effects of various imidazoline and nonimidazoline α-adrenergic agents on aggregation antiaggregation bovine equine platelets. Sample —Blood samples obtained from 8 healthy adult cattle 16 Thoroughbreds. Procedures —Aggregation platelets were determined via a turbidimetric method. Collagen ADP used to initiate aggregation. Results —Adrenaline, noradrenaline, or α-adrenoceptor alone did not induce changes in potentiate ADP- collagen-induced platelet...
Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate (GPT). The improved synthesis detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.