A5051384777- RNA and protein synthesis mechanisms
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Lipid Membrane Structure and Behavior
- Sphingolipid Metabolism and Signaling
- Drug Transport and Resistance Mechanisms
- Neonatal Health and Biochemistry
National University of Singapore
2023
Duke-NUS Medical School
2023
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that constitutes main pathway by which brain obtains omega-3 fatty acids, such as docosahexanoic acid. Mfsd2a deficiency in humans results severe microcephaly, underscoring importance of LPC transport for development. Biochemical studies and recent cryo-electron microscopy (cryo-EM) structures bound to suggest transports via an...
The liver has a high demand for phosphatidylcholine (PC), particularly in overnutrition, where reduced phospholipid levels have been implicated the development of nonalcoholic fatty disease (NAFLD). Whether other pathways exist addition to de novo PC synthesis that contribute hepatic pools remains unknown. Here, we identified lysophosphatidylcholine (LPC) transporter major facilitator superfamily domain containing 2A (Mfsd2a) as critical maintaining pools. Hepatic Mfsd2a expression was...
Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic reperfusion (IRI), main cause of AKI, the brush border membrane S3 proximal tubules (PT) lost to tubular lumen. How injured reconstitute lipids during renal recovery not known. Here, we identified Mfsd2a, sodium-dependent lysophosphatidylcholine (LPC) transporter, be expressed specifically in basolateral PT. Using an vivo activity probe for transport was found specific Mice...