A5101988436- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Anesthesia and Sedative Agents
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Proteoglycans and glycosaminoglycans research
- Anesthesia and Pain Management
- Periodontal Regeneration and Treatments
- Sports injuries and prevention
- Mechanisms of cancer metastasis
- Botanical Research and Chemistry
- Mesenchymal stem cell research
- Receptor Mechanisms and Signaling
- Pediatric health and respiratory diseases
- Foot and Ankle Surgery
- Musculoskeletal pain and rehabilitation
- Tendon Structure and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Pain Management and Opioid Use
- Plant and fungal interactions
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
Funabashi Orthopaedic Hospital
2016-2024
Kagawa University
2022-2023
Mie University Hospital
2022
Chiba University
1966-2021
Tokyo University of Agriculture and Technology
2021
Self-Defense Forces Central Hospital
2016-2020
Institute for Community Living
2020
Brigham and Women's Hospital
2014-2019
Harvard University
2014-2019
Tokyo University of Pharmacy and Life Sciences
2019
Treating articular cartilage defects is a demanding problem. Although several studies have reported durable and improved clinical outcomes after autologous chondrocyte implantation (ACI) over long-term period, there no report with 20 years' follow-up.To evaluate first-generation ACI for the treatment of knees disabling, large single multiple which patients wished to avoid prosthetic arthroplasty, minimum follow-up.Case series; Level evidence, 4.The authors reviewed prospectively collected...
Little is known regarding the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) with regard to Knee injury Osteoarthritis Outcome Score (KOOS), International Documentation Committee (IKDC) Subjective Evaluation Form, Lysholm score, Short Form 12 (SF-12) score of patients who undergo osteochondral allograft transplantation (OCA). We aimed determine MCID SCB associated those patient-reported outcome measures (PROMs) after OCA.We analyzed data 86 consecutive...
Background: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) inevitable if articular congruence not restored. Purpose: To describe the autologous chondrocyte implantation (ACI) “sandwich” technique bone grafting (ABG) and compare it ABG alone for restoration of unit. The midterm long-term...
We sought to determine the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) associated with Knee Injury Osteoarthritis Outcome Score (KOOS), International Documentation Committee (IKDC) Subjective Evaluation Form, Lysholm, Short Form-12 (SF-12) after autologous chondrocyte implantation (ACI).Ninety-two patients satisfaction surveys at a minimum of 2 years postoperatively least 1 repeated patient-reported outcome measure (PROM) were analysed. The MCID was...
1Cartilage Repair Center, Brigham and Women's Hospital, Chestnut Hill, Massachusetts aE-mail address for T. Bryant: [email protected]
Treating symptomatic articular cartilage lesions is challenging, especially in adolescent patients, because of longer life expectancies and higher levels functional activity. For this population, long-term outcomes after autologous chondrocyte implantation (ACI) remain to be determined.To evaluate adolescents ACI using survival analyses, validated outcome questionnaires, standard radiographs.Case series; Level evidence, 4.We performed a review prospectively collected data from patients who...
Background: Treating bipolar chondral lesions in the patellofemoral (PF) compartment is a challenging problem. There are few reports available on treatment of PF compartment. Purpose: To evaluate clinical outcomes and graft survivorship after autologous chondrocyte implantation (ACI) for Study Design: Case series; Level evidence, 4. Methods: The authors evaluated 58 patients who had ACI by single surgeon symptomatic between November 1995 June 2014. All (60 knees; mean age, 36.6 years) were...
Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial avoid the progression osteoarthritis (OA). Purpose: To describe autologous chondrocyte implantation (ACI) “segmental-sandwich” technique for unit and evaluate midterm outcomes treated this procedure. Correlations between magnetic resonance imaging (MRI) radiographic findings were assessed. Study Design: Case...
Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation (ACI) allograft transplantation (MAT), longer needed.To evaluate mid- long-term combined ACI with MAT.Case series; Level of evidence, 4.We performed a retrospective review prospectively gathered data from patients who had undergone MAT between 1999 2013. A single surgeon treated 18...
Background: Treating bipolar chondral lesions in the tibiofemoral (TF) compartment with cartilage repair procedures is challenging, and a suitable treatment remains unclear. Purpose: To evaluate clinical outcomes after autologous chondrocyte implantation (ACI) for of TF compartment. Study Design: Case series; Level evidence, 4. Methods: We evaluated 57 patients who underwent ACI symptomatic by single surgeon between October 1995 June 2014. One patient did not return follow-up. Thus, 56 (58...
It is unknown how ketamine anesthesia immunologically affects the outcome of patients with postoperative septicemia. We investigated effects on mice an Escherichia coli or lipopolysaccharide (LPS) challenge after laparotomy, focusing phagocytosis by liver macrophages (Kupffer cells) and cytokine production.C57BL/6 received sevoflurane during which was followed E. LPS challenge; thereafter, mouse survival rates secretions were examined. The a β-adrenoceptor antagonist, nadolol, also assessed...
Customized Individually Made (CIM) Bicompartmental Knee Arthroplasty (BKA) implants and three-dimensional printed customized instruments are available to fit each patient's unique anatomy, medial or lateral with patellofemoral. This study aimed evaluate the clinical outcomes after CIM-BKA.Fifty-five patients [59 knees; average age, 51 years; standard deviation (SD), 6.8; range 37-65 years] who underwent CIM-BKA were evaluated over an of 3.8-year follow-up (SD 1.6; 1-6 years). Forty-one knees...
The use of vegetable proteins as food ingredient is becoming increasingly important due to their high versatility and environmental acceptability. This work describes a chemical characterization techno-functional properties (emulsifying foaming properties) 3 protein fractions obtained from protein-rich novel lupin variety, AluProt-CGNA(®) . nongenetically modified variety have great content in dehulled seeds (60.6 g protein/100 g, dry matter), which higher than soybean other varieties. A...
Phosphodiesterase (PDE)-3B, a major PDE isoform in adipocytes, plays pivotal role the antilipolytic action of insulin. Insulin-induced phosphorylation and activation PDE3B is phosphatidylinositol 3-kinase (PI3-K) Akt dependent, but precise mechanism not fully understood. We have identified 14-3-3 β, critical scaffolding molecule signal transduction, as protein that interacts with using yeast two-hybrid system. The interaction between β was then confirmed vitro. glutathione S-transferase...
Propofol is an intravenous sedative hypnotic, which, acting as a GABAA agonist, results in neocortical inhibition. While propofol has been well studied at the molecular and clinical level, less known about effects of level individual neurons local networks. We used Utah Electrode Arrays (UEAs) to investigate anesthesia on action potentials (APs) field (LFPs). UEAs were implanted into neocortex two humans three felines. The human patients one feline received by bolus injection, while other...
Meniscal injuries are a risk factor for osteoarthritis (OA). While mechanical pathway between meniscal injury and OA has been described, the biological effects of inflammation on this have yet to be clarified. The aim our study was compare levels specific inflammatory mediators, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), nerve growth (NGF), in injured uninjured tissue related knee joint synovium. Tissue samples were obtained from 19 patients, 31.1 ± 13.6 years old, who...
Objective Osteochondral allograft transplantation (OCA) is a well-established procedure for patients with symptomatic cartilage defects in the knee. Revision to OCA after prior failed repair has shown similar clinical outcomes as primary OCA; however, most of procedures were arthroscopic smaller defects. There no literature investigating autologous chondrocyte implantation (ACI) treatment large chondral The purpose this study was therefore determine undergoing revision ACI compared matched...
Autologous chondrocyte implantation (ACI) is a well-established cartilage repair procedure; however, numerous studies have shown higher ACI graft failure rates after prior marrow stimulation techniques (MSTs).To identify which factors may predict decreased survival among patients who underwent MST. A secondary aim was to investigate the specificity of these predictors.Case-control study; Level evidence, 3.In this review prospectively collected data, authors analyzed 38 had failed MST surgery...