A5070160033- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiomyopathy and Myosin Studies
- MRI in cancer diagnosis
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Lanthanide and Transition Metal Complexes
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Coronary Artery Anomalies
- Neurological disorders and treatments
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Ultrasound Imaging and Elastography
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
1999-2024
GDI Integrated Facility Services (Canada)
2023
University Hospital Heidelberg
2021
Heidelberg University
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2010-2019
University Hospital of Bern
2019
Cancer Center Amsterdam
2018
TH Bingen University of Applied Sciences
2016
Ospedali Riuniti Umberto I
2016
Quantitative T1-mapping is rapidly becoming a clinical tool in cardiovascular magnetic resonance (CMR) to objectively distinguish normal from diseased myocardium. The usefulness of any quantitative technique identify disease lies its ability detect significant differences an established range values. We aimed assess the variability myocardial T1 relaxation times human population estimated with recently proposed Shortened Modified Look-Locker Inversion recovery (ShMOLLI) mapping technique. A...
Background The clinical significance of anomalously originating coronary arteries depends on their proximal course. Diagnosis this course by conventional x-ray angiography alone may be equivocal. We postulated that with fast magnetic resonance (MR) angiography, accurate detection anomalous and unambiguous delineation is feasible. Methods Results In a selected group 38 patients, 19 them having an artery, MR angiographic technique was used to study the anatomy. Blinded analysis randomly...
Cardiovascular magnetic resonance (CMR) allows non-invasive phase contrast measurements of flow through planes transecting large vessels. However, some clinically valuable applications are highly sensitive to errors caused by small offsets measured velocities if these not adequately corrected, for example the use static tissue or phantom correction offset error. We studied severity uncorrected velocity across sites and CMR systems. In a multi-centre, multi-vendor study, breath-hold...
Abstract Motion of the coronary arteries during heart cycle can result in image blurring and inaccurate flow quantification by MR. This condition applies particularly for longer acquisition windows that are typical breath‐hold measurements. To determine sensitivity technique to in‐plane motion different arteries, temporal variation position was measured a plane perpendicular proximal portion vessel. The results indicated presence substantial displacement within cardiac cycle, with magnitude...
To evaluate which cardiac magnetic resonance (MR) imaging technique for detection of microvascular obstruction (MVO) best predicts left ventricular (LV) remodeling after acute myocardial infarction (MI).This study had local ethics committee approval; all patients gave written informed consent. Sixty-three with first MI, treated primary stent placement and optimal medical therapy, underwent cine MR at 4-7 days 4 months MI. Presence MVO was qualitatively evaluated baseline by using three...
Background— Alcohol septal ablation (ASA) reduces left ventricular outflow tract (LVOT) pressure gradient in patients with hypertrophic obstructive cardiomyopathy (HOCM), which leads to remodeling. We sought describe the early midterm changes and modulating factors of remodeling process using cardiac MRI (CMR). Methods Results— CMR was performed at baseline 1 6 months after ASA 29 HOCM (age 52±16 years). Contrast-enhanced showed no infarct-related hyperenhancement outside target area. Septal...
The accuracy of magnetic resonance phase contrast volume flow measurements in small blood vessels is expected to be smaller than large vessels, because partial effects at the vessel boundary. Accuracy was validated dog femoral artery, diameter 3.5 +/- 0.7 mm, using an ultrasonic transit-time flowmeter (TT). number pixels per (ND) ranged from 1.6 4.8. cross-section determined a threshold magnitude image. Between two methods correlation coefficient 0.95 (range 10-200 ml/min). proportional...
The accuracy of magnetic resonance angiography in detecting proximal coronary artery stenoses is unclear. We postulated that fast capable (1) imaging arteries, and (2) > or = 50% their luminal diameter.Thirty-five patients, referred for analysis angina pectoris, underwent both conventional arteries. A k-space segmented gradient-echo technique was used during breath-holds. Two observers, blinded to the results angiography, independently analysed studies length visualized segments, presence...
Abstract Flow in the human right coronary artery was determined using magnetic resonance phase contrast velocity quantification. Two methods were applied to reduce respiratory motion: imaging during breath holding, which is fast, and retrospective gating, has a high temporal resolution (32 ms) cardiac cycle. Vessel cross‐sectional area, through‐plane velocity, volume flow six healthy subjects. In‐plane vessel displacement cycle, caused by contraction, about 2–4 mm within time frame of 32 ms...
Abstract Purpose To investigate whether an existing method for correction of phase offset errors in phase‐contrast velocity quantification is applicable assessment main pulmonary artery flow with MR scanner equipped a high‐power gradient system. Materials and Methods The consists fitting surface through the time average stationary pixels velocity‐encoded images, subtracting this from images. Pixels are regarded as if their standard deviation falls into lowest percentile. Flow was measured 15...
In hypertrophic cardiomyopathy (HCM), autopsy studies revealed both increased focal and diffuse deposition of collagen fibers. Late gadolinium enhancement imaging (LGE) detects fibrosis, but is unable to depict interstitial fibrosis. We hypothesized that with T1 mapping, which employed determine the myocardial extracellular volume fraction (ECV), can detect fibrosis in HCM patients.
Cardiac magnetic resonance imaging of the pressure overloaded right ventricle (RV) precapillary pulmonary hypertension (PH) patients, exhibits late gadolinium enhancement at interventricular insertion regions, a phenomenon which has been linked to focal fibrosis. Native T1-mapping is an alternative technique characterize myocardium and advantage not requiring use contrast agents. The aim this study was idiopathic arterial (IPAH), systemic scleroderma related PH (PAH-Ssc) chronic...
Identification of flow patterns within the heart has long been recognized as a potential contribution to understanding physiological and pathophysiological processes cardiovascular diseases. Although pulsatile itself is multi-dimensional multi-directional, current available non-invasive imaging modalities in clinical practice provide calculation only 1-direction lack 3-dimensional volumetric velocity information. Four-dimensional magnetic resonance (4D CMR) emerged novel tool that enables...
Several gradient-echo fMRI blood oxygenation level-dependent (BOLD) effects are described in the literature: extravascular spin dephasing around capillaries and veins, intravascular phase changes, transverse relaxation changes of blood. This work considers a series tissue compartmentalized models incorporating each these effects, tries to determine model which is most consistent with data. To isolate different contributions, multi-echo inversion recovery (IR) scans were performed. Visual...
Eddy current induced velocity offsets are of concern for accuracy in cardiovascular magnetic resonance (CMR) volume flow quantification. However, currently known theoretical aspects eddy behavior have not led to effective guidelines the optimization quantification sequences. This study is aimed at identifying correlations between protocol parameters and resulting error clinical CMR measurements a multi-vendor study. Nine 1.5T scanners three different types/vendors were studied. Measurements...
AimsThe combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation morphology function. Cardiovascular magnetic resonance (CMR) has several advantages: it can simultaneously assess perfusion, ventricular valvular function, cardiomyopathy, aortic disease does not involve any additional ionizing radiation. We investigated CT CMR for diagnostic patients with suspected artery (CAD) in clinical practice.