A5063065750- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Noise Effects and Management
- Atrial Fibrillation Management and Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inflammasome and immune disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Viral Infections and Vectors
- Cardiac tumors and thrombi
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- COVID-19 epidemiological studies
- DNA Repair Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cardiovascular Function and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
University Medical Center of the Johannes Gutenberg University Mainz
2018-2025
Johannes Gutenberg University Mainz
2017-2025
General Department of Preventive Medicine
2021-2023
German Centre for Cardiovascular Research
2019-2023
University Medical Centre Mannheim
2014
Heidelberg University
2014
Airborne transmission by droplets and aerosols is important for the spread of viruses. Face masks are a well-established preventive measure, but their effectiveness mitigating SARS-CoV-2 still under debate. We show that variations in mask efficacy can be explained different regimes virus abundance related to population-average infection probability reproduction number. For SARS-CoV-2, viral load infectious individuals vary orders magnitude. find most environments contacts conditions low...
Epidemiological studies indicate that traffic noise increases the incidence of coronary artery disease, hypertension and stroke. The underlying mechanisms remain largely unknown. Field with nighttime exposure demonstrate aircraft leads to vascular dysfunction, which is markedly improved by vitamin C, suggesting a key role oxidative stress in causing this phenomenon.We developed novel animal model study consequences exposure. Peak sound levels 85 mean level 72 dBA applied loudspeakers for 4...
Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation increases the incidence of coronary artery disease, hypertension, stroke. The underlying mechanisms are not well understood. Herein, we investigated effects phagocyte-type NADPH oxidase (Nox2) knockout different protocols (around-the-clock, sleep/awake phase noise) on vascular cerebral complications in mice.C57BL/6j Nox2-/- (gp91phox-/-) mice were exposed to aircraft (maximum sound level 85...
The role of the BARD1 gene in breast cancer (BC) and ovarian (OC) predisposition remains elusive, as published case-control investigations have revealed controversial results. We aimed to assess deleterious germline variants BC/OC a sample 4920 BRCA1/2-negative female index patients German Consortium for Hereditary Breast Ovarian Cancer (GC-HBOC). A total 4469 with BC, 451 OC, 2767 geographically matched control individuals were screened loss-of-function (LoF) mutations potentially damaging...
Traffic noise may play an important role in the development and deterioration of ischaemic heart disease. Thus, we sought to determine mechanisms cardiovascular dysfunction inflammation induced by aircraft a mouse model myocardial infarction (MI) humans with incident MI.C57BL/6J mice were exposed alone (average sound pressure level 72 dB; peak 85 dB) for up 4 days, resulting pro-inflammatory aortic gene expression myeloid cell adhesion/diapedesis pathways. The promoted adhesion infiltration...
Environmental stressors such as traffic noise represent a global threat, accounting for 1.6 million healthy life years lost annually in Western Europe. Therefore, the noise-associated health side effects must be effectively prevented or mitigated. Non-pharmacological interventions physical activity balanced diet are effective due to activation of adenosine monophosphate-activated protein kinase (α1AMPK). Here, we investigated first time murine model aircraft noise-induced vascular...
<title>Abstract</title> The emergence of post-COVID sequelae (PCS) represents a global challenge. However, understanding biological mechanisms and the definition quantifiable risk factors remains limited. This study harnessed power predictive machine learning models to explore potential proteomics in predicting individual symptoms their collective manifestation as PCS. analysis utilized panel approximately 2900 proteins measured 495 COVID-19 patients. identified 235 unique associated with 21...
Abstract Background and Aims Chronic inflammation autoimmunity contribute to cardiovascular (CV) disease. Recently, autoantibodies (aAbs) against the CXC-motif-chemokine receptor 3 (CXCR3), a G protein-coupled with key role in atherosclerosis, have been identified. The of anti-CXCR3 aAbs for CV risk disease is unclear. Methods Anti-CXCR3 were quantified by commercially available enzyme-linked immunosorbent assay 5000 participants (availability: 97.1%) population-based Gutenberg Health Study...
Animal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa) safely prevents venous thromboembolism (VTE), specific murine models sepsis have shown potential efficacy in alleviating cytokine storm. These latter findings support the role FXI beyond coagulation. Here, we combine targeted proteomics, machine learning bioinformatics, to discover associations between activity (FXI:C) plasma protein profile patients with VTE. FXI:C was measured a modified activated...
(1) Background: Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere biology is relevant to several human disorders and diseases, specifically cardiovascular disease. To better understand link between disease telomere length, we studied effect relative length (RTL) on risk factors in a large population-based sample. (2) Methods: RTL was measured by real-time quantitative polymerase chain reaction subjects Gutenberg Health...
Recurrent events frequently occur after venous thromboembolism (VTE) and remain difficult to predict based on established genetic, clinical, proteomic contributors. The role of circulating microRNAs (miRNAs) has yet be explored in detail.To identify miRNAs predictive recurrent VTE or death, interpret their mechanistic involvement.Data from 181 participants a cohort study acute 302 individuals with history population-based were investigated. Next-generation sequencing was performed EDTA...
Targeted proteomics utilizing antibody-based proximity extension assays provides sensitive and highly specific quantifications of plasma protein levels. Multivariate analysis this data is hampered by frequent missing values (random or left censored), calling for imputation approaches. While appropriate missing-value methods exist, benchmarks their performance in targeted are lacking. Here, we assessed the two completely at random, previously top-benchmarked ‘missForest’ recently published...
Use of galectin-3 for assessing cardiac function in prediabetes and type 2 diabetes mellitus (T2DM) needs to be established. Within the Gutenberg Health Study cohort (N = 15,010, 35-74 years) patient characteristics were investigated regarding levels. Prognostic value compared NT-proBNP concerning mortality was assessed individuals with euglycaemia, T2DM 5 years follow-up. Higher levels related older age, female sex higher prevalence prediabetes, T2DM, cardiovascular risk factors...
Individuals with acute venous thromboembolism (VTE) constitute a heterogeneous group of patients diverse clinical characteristics and outcome.To identify endotypes individuals VTE based on at presentation through unsupervised cluster analysis to evaluate their molecular proteomic profile outcome.Data from 591 the Genotyping Molecular phenotyping Venous (GMP-VTE) project were explored. Hierarchical clustering was applied 58 variables define endotypes. Clinical characteristics, three-year...
Abstract Airborne transmission by droplets and aerosols is important for the spread of viruses face masks are a well-established preventive measure, but their effectiveness mitigating COVID-19 still under debate. We show that variations in mask efficacy can be explained different regimes virus abundance. For SARS-CoV-2, load infectious individuals vary orders magnitude, we find most environments contacts virus-limited regime where simple surgical highly effective on individual...
Distinct patterns of circulating microRNAs (miRNAs) were found to be involved in misguided thrombus resolution. Thus, we aimed investigate dysregulated miRNA signatures during the acute phase pulmonary embolism (PE) and test their diagnostic predictive value for future diagnosis chronic thromboembolic hypertension (CTEPH). Microarray screening subsequent validation a large patient cohort (n = 177) identified three miRNAs as potential biomarkers: miR-29a miR-720 significantly upregulated...
Abstract The obesity paradox, the controversial finding that promotes disease development but protects against sequelae in patients, has been observed venous thromboembolism (VTE). aim of this investigation was to identify a body mass–related proteomic signature VTE patients and evaluate whether mediates paradox patients. Data from Genotyping Molecular Phenotyping Venous ThromboEmbolism Project, prospective cohort study 693 were analyzed. A combined end point recurrent or all-cause death...
Introduction Platelets contribute to the development of cardiovascular diseases with arterial or venous origin. This study aimed compare platelet ADP and epinephrine hyperaggregability other function tests determine predictive value clinical factors common genetic variants.