A5080624057- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Blood Coagulation and Thrombosis Mechanisms
- Workplace Health and Well-being
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Ovarian cancer diagnosis and treatment
- Diagnosis and Treatment of Venous Diseases
- Microtubule and mitosis dynamics
- Pharmaceutical Economics and Policy
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Atherosclerosis and Cardiovascular Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Employment and Welfare Studies
- Inflammatory Biomarkers in Disease Prognosis
- BRCA gene mutations in cancer
German Centre for Cardiovascular Research
2019-2025
University Medical Center Hamburg-Eppendorf
2020-2025
Universität Hamburg
2020-2025
University Cancer Center Hamburg
2024
University Medical Center of the Johannes Gutenberg University Mainz
2016-2023
Johannes Gutenberg University Mainz
2015-2023
Martini-Klinik
2023
Boise State University
2021
Kent State University
2019
Kiel University
2012-2018
Abstract Background and Aims Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates association between Lp(a) coronary heart (CHD) in general population. Methods Data from 71 678 participants 8 European prospective population-based cohort studies were used (65 661 without/6017...
Heme oxygenase-1 (HO-1) confers protection to the vasculature and suppresses inflammatory properties of monocytes macrophages. It is unclear how HO-1 determines extent vascular dysfunction in mice humans. Decreased activity expression was paralleled by increased aortic nicotinamide dinucleotide phosphate oxidase Nox2 deficient Hmox1−/− Hmox1+/− compared with Hmox1+/+ mice. When subjected angiotensin II-infusion, streptozotocin-induced diabetes mellitus aging, showed inversely correlated HO...
Evidence regarding the health burden of chronic venous insufficiency (CVI), its clinical determinants, and impact on outcome is scarce.Systematic phenotyping CVI according to established CEAP (Clinical-Etiologic-Anatomic-Pathophysiologic) classification was performed in 12 423 participants (age range: 40-80 years) Gutenberg Health Study from April 2012 2017. Prevalence calculated age- sex-specifically. Multivariable Poisson regression models were evaluate relation with cardiovascular...
Aim: To evaluate the evolution of glycemic outcomes in patients living with type 1 diabetes (T1D) after year use MiniMed 780G advanced hybrid closed-loop (AHCL) system. Methods: We conducted an observational, retrospective, multicentric study 20 centers France. The primary objective was to improvement control 1-year AHCL. endpoint variation time range (TIR) between pre-AHCL and Secondary objectives were analyze 3, 6, 12 months AHCL use, safety, long-term observance Results: Two hundred...
OBJECTIVE: This study aimed to determine if there is an increased risk of incident cardiovascular diseases (CVD) resulting from cumulative night shift work in the German population-based Gutenberg Health Study (GHS). METHODS: We examined working participants GHS at baseline and after five years. Cumulative 10 years before was assessed categorized as low (1–220 nights ≙ up 1 year), middle (221–660 1–3 years), high (>660 more than 3 years) exposure. Hazard ratios (HR) were estimated for...
Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseases. This study aims explore the relation between thrombin and factors, diseases, total mortality. For this study, N=5000 subjects from population-based Gutenberg Health Study were analysed in highly standardized setting. was assessed by Calibrated Automated Thrombogram method at 1 5 pM tissue factors trigger platelet poor plasma. Lag time, endogenous potential, peak height derived curve....
Abstract Background Cigarette smoking is a threat to global human health and leading cause of the cardiovascular disease (CVD) morbidity mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key event development atherosclerotic CVD, remain still elusive. Thus, this study sought out investigate associations between measures stiffness. Methods results Overall, 15,010 participants (7584 men 7426 women aged 35–74 years) Gutenberg Health Study were...
Zusammenfassung Die aktuelle Leitlinie der ESC (European Society of Cardiology) zum chronischen Koronarsyndrom (CCS) bringt einige Neuerungen in medikamentösen Therapie von CCS-Patienten. Diese betreffen die antithrombotischen, lipidsenkenden, metabolischen, antihypertensiven sowie antiinflammatorischen Grundpfeiler Therapie. Neben neuen Empfehlungen für eine individuelle antithrombotische wird erstmalig Bedeutung einer Medikation bei bestimmten CCS-Patienten zur Reduktion des residuellen...
Abstract Aims Platelet indices have been associated with traditional cardiovascular risk factors, diseases and all‐cause mortality. This study aimed to investigate the role of platelet count, mean volume (MPV) platelet‐to‐leukocyte ratio, including platelet‐to‐monocyte platelet‐to‐lymphocyte ratio cardiac function, heart failure (HF) phenotypes clinical outcome, worsening HF. Methods results Univariate multivariable linear Cox regression analyses were used associations between indices,...
Aims: Cigarette smoking is one of the most complex and least understood cardiovascular risk factors. Importantly, differences in tobacco-related pathophysiology endothelial dysfunction, an early event atherogenesis, between circulatory beds remain elusive. Therefore, this study evaluated how impacts function conduit resistance arteries a large population-based cohort. Methods results: 15,010 participants (aged 35–74 years) Gutenberg Health Study were examined at baseline from 2007 to 2012....
Research on animal ethics in tourism has gained traction but posthumanist approaches to wildlife (eco)tourism remain sparse. There never been a more urgent need redress this paucity theory and practice. More than 60% of the world’s died-off last 50 years, 100 million-plus nonhuman animals are used for entertainment tourist attractions (WTAs), one billion “wildlife” live captivity, some scholars argue that earth entered its sixth mass extinction event known as Anthropocene. This paper...
Previous reports have investigated the impact of age on D-Dimer testing in elderly individuals with suspected deep vein thrombosis (DVT), but data age-related diagnostic value D-dimer a sample covering broad range are limited. The present study determined age-specifically accuracy and compared it to C-reactive protein (CRP), marker inflammation, 500 patients DVT from VTEval project (NCT02156401). Sensitivity was lower < 60 years comparison ≥ (∆-16.8%), whereas specificity 27.9% higher....
The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development cardiovascular disease (CVD). Data investigating this interplay using index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific SI inflammatory hemostatic biomarkers was investigated within 13,724 subjects from population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18,...
The sodium-glucose co-transporter 2 inhibitor empagliflozin improves cardiovascular outcome in patients with type diabetes mellitus (T2DM) and heart failure. Experimental studies suggest a direct cardiac effect of associated an improvement left ventricular diastolic function.In the randomized, double-blind, two-armed, placebo-controlled, parallel group trial EmDia, T2DM elevated E/E´ ratio were enrolled randomized 1:1 to receive 10 mg/day versus placebo. primary endpoint was change after 12...
Graphical AbstractOpen in new tabDownload slideFacing the public health threat: syphilis resurgence and cardiovascular risk
Higher, but also lower resting heart rate (HR), has been associated with increased cardiovascular events and mortality. Little is known about the interplay between HR, risk factors, concomitant diseases, vascular (endothelial) function, neurohormonal biomarkers, all-cause mortality in general population. Thus, we aimed to investigate these relationships a population-based cohort. 15,010 individuals (aged 35–74 at enrolment 2007–2012) from Gutenberg Health Study were analyzed. Multivariable...
Abstract In a large German community sample of adults, we investigated the association chronic anxiousness with cardiovascular disease and mortality. Self-reported from 11,643 adults between 40 80 years age Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression modeling assessed relation variables, Twelve percent participants reported consistently raised (chronic) at least 2.5 Anxiousness more often by female, younger lower socioeconomic status, smokers those family...
Background and Objective Nutrition body weight are modifying factors for periodontitis. The purpose of this study was to quantify two molecules (ghrelin chemerin), released in association with food intake obesity, periodontally healthy diseased individuals respect different mass categories. Material Methods main groups (patients chronic periodontitis healthy/gingivitis volunteers) were subdivided into subjects normal [body index ( BMI) <25] overweight/obese BMI ≥25). Subgingival bacteria...