A5019909056- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Inflammation biomarkers and pathways
- Retinoids in leukemia and cellular processes
- Cytokine Signaling Pathways and Interactions
- Climate Change and Health Impacts
- Biomarkers in Disease Mechanisms
- Cardiovascular Disease and Adiposity
- S100 Proteins and Annexins
- Noise Effects and Management
- Macrophage Migration Inhibitory Factor
Johannes Gutenberg University Mainz
2021-2024
University Medical Center of the Johannes Gutenberg University Mainz
2021-2024
Heidelberg University
2023
German Cancer Research Center
2023
Traffic noise may play an important role in the development and deterioration of ischaemic heart disease. Thus, we sought to determine mechanisms cardiovascular dysfunction inflammation induced by aircraft a mouse model myocardial infarction (MI) humans with incident MI.C57BL/6J mice were exposed alone (average sound pressure level 72 dB; peak 85 dB) for up 4 days, resulting pro-inflammatory aortic gene expression myeloid cell adhesion/diapedesis pathways. The promoted adhesion infiltration...
The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well cardiovascular disease progression. Since myeloid cells are primary source of IL-6 formation, we aimed to generate mouse model study cell-derived vascular disease.
Abstract Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) in psoriasis patients five murine models of psoriasis-like skin disease based on topical imiquimod application overexpression IL-17A under different promotors. We performed a single-center prospective observational German population, investigating...
Psoriasis is an immune-mediated inflammatory skin disease driven by interleukin-17A (IL-17A) and associated with cardiovascular dysfunction. We used a severe psoriasis mouse model of keratinocyte IL-17A overexpression (K14-IL-17Aind/+ , IL-17Aind/+ control mice) to investigate the activity neutrophils potential cellular interconnection between vasculature. Levels dermal reactive oxygen species (ROS) their release were measured lucigenin-/luminol-based assays, respectively. Quantitative...
Background: Psoriasis is a systemic inflammatory disorder, primarily characterized by skin plaques. It linked to co-morbidities including cardiovascular disease and metabolic syndrome. Several studies demonstrate that dietary habits can influence psoriasis development severity. However, the effect of different protein levels on severity poorly understood. In this study, we examine psoriasis-like in mice. Methods: We fed male C57BL/6J mice with regular, low high chow for 4 weeks. Afterwards,...
Abstract Background Psoriasis is the most common chronic skin disease worldwide. Furthermore, it an independent cardiovascular risk factor. Several genetic and inducible murine models reproduce specific aspects of human disease. In mice genetically overexpressing IL-17A in keratinocytes or dendritic cells, we coulod show both disease: cutaneous hallmarks vascular phenotype. The popular model consists topical application Imiquimod (IMQ), a Toll-like receptor 7/8 agonist. this model, have not...