A5069589716- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Obstructive Sleep Apnea Research
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrhythmias and Treatments
- Peripheral Artery Disease Management
- Cardiovascular and exercise physiology
- Congenital Heart Disease Studies
- Atrial Fibrillation Management and Outcomes
- Tracheal and airway disorders
- Acute Myocardial Infarction Research
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Vascular Procedures and Complications
- Pulmonary Hypertension Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
Goethe University Frankfurt
2020-2023
University Hospital Frankfurt
2020-2023
Limassol General Hospital
2023
Johannes Gutenberg University Mainz
2018-2020
German Centre for Cardiovascular Research
2019
Heart and Diabetes Center North Rhine-Westphalia
2011-2018
Ruhr University Bochum
2010-2017
Eastbourne District General Hospital
2016
Cheyne-Stokes respiration (CSR) in patients with chronic heart failure (CHF) is of major prognostic impact and expresses respiratory instability. Other parameters are daytime pCO₂, VE/VCO₂-slope during exercise, exertional oscillatory ventilation (EOV), increased sensitivity central CO₂ receptors. Adaptive servoventilation (ASV) was introduced to specifically treat CSR CHF. Aim this study investigate ASV effects on CSR, cardiac function, stability. A total 105 CHF (NYHA ≥ II, left...
Cheyne‐Stokes Respiration and Arrhythmias Objective This study aimed to investigate whether adequate treatment of respiration (CSR) reduces the risk arrhythmic events in patients with chronic heart failure (CHF). Methods A cohort 403 registry CHF (LVEF≤45%, NYHA‐class≥2) implanted cardioverter‐defibrillator devices (ICD) was studied. They underwent overnight polygraphy, 221 having mild or no CSR (apnea‐hypopnea index [AHI]<15/h), 182 moderate severe (AHI>15/h). Latter ones were offered...
In patients with type 2 diabetes mellitus (T2DM) exercise training is recommended to improve glycemic control. Electrical myostimulation (EMS) of skeletal muscles a new method increase capacity in chronic heart failure. The aim this study was investigate the effects EMS T2DM on glucose metabolism, body composition, and performance using newly designed stimulation suit that involves trunk, leg, arm muscles.Fifteen individuals (nine males; 61.7±14.8 years old) were trained for 10 weeks twice...
Abstract Objective To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in complex patient population diabetes mellitus after follow-up period 5 years. Background After percutaneous coronary intervention patients are under higher risk death, restenosis thrombosis (ST) compared to non-diabetic patients. Methods In 126 centers worldwide 3067 were enrolled NOBORI 2 registry, 888 suffered from (DM), 213 them (14%) being...
Abstract Background and Objectives Transcatheter aortic valve replacement (TAVR) via femoral access is a new option for patients with severe stenosis considered to be at high risk conventional open‐heart surgery. This procedure requires peripheral arteries that are able accommodate the large sheaths required delivery. We present series of suboptimal vascular conditions, who received self‐expandable sheath. Methods Results From January 2009 September 2011, total 96 (43% male) were treated 18F...
Evaluation of the impact sheath diameter on vascular complications and mortality in transfemoral aortic valve implantation.Between 2012 2014, 183 patients underwent procedure using a 18-24 F. This collective was divided into two groups: group 1, with 18F (G1, n = 94), consisted Medtronic Sentrant 18 F Direct Flow sheaths, 2 19-24 (G2, 89) Edwards expandable e-sheath Solopath sheaths. Perclose-Proglide® used as closure device all patients.G1 had significantly more female (64.9% vs. 46.1% G2,...
To investigate three-year outcomes of patients presenting with nonSTelevation acute coronary syndrome (NSTE-ACS) treated bioresorbable everolimus-eluting vascular scaffolds (BRS).The study included a total 488 consecutive patients, enrolled between May 2012 and December 2013 (median age 65 [56-74], 392 men. 269 presented either NSTEMI or unstable angina at the time enrolling, 219 stable silent angina. The primary device-oriented endpoint (Target Lesion Failure, TLF) was defined as...
The technique used at the time of implantation has a central role in determining risk thrombosis bioresorbable vascular scaffolds (BRS). Different definitions “optimal” exist, however. impact individual procedural characteristics on scaffold (ScT) was evaluated single-center observational study that enrolled 657 patients (79% males, mean age 63 ± 12 years) with 763 lesions who received total 925 BRS for de novo lesions. During median 1076 (762–1206) days’ follow-up there were 28 cases...
Many patients with peripheral arterial disease (PAD) exhibit undiagnosed obstructive coronary artery disease. We aim to identify the lifestyle limiting claudication due PAD and without cardiac symptoms, requiring revascularization based on high-sensitive troponin T (hsTnT) values. assessed hsTnT in consecutive referred for elective endovascular treatment [Rutherford categories (RC) 2 & 3] between January 2018 December 2021. Diagnostic work-up by non-invasive imaging and, if required,...
(1) Background: Knowledge about predictors for the long-time patency of recanalized chronic total coronary occlusions (CTOs) is limited. Evidence from invasive follow-up in absence acute syndrome (routine surveillance angiography) scarce. (2) Methods: In a monocentric-retrospective analysis, we obtained baseline as well periprocedural data patients undergoing routine follow-up. We defined target vessel failure (TVF) combined primary endpoint, consisting re-occlusion, restenosis, and...
Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing valve surgery were prospectively enrolled received cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two them underwent follow-up examination...
The aim of this study is to provide evidence on how use standardized intravascular ultrasound (IVUS) impacts stent size choice in the setting chronic total occlusion (CTO) percutaneous coronary intervention (PCI) compared visual estimation.Data 82 consecutive patients who had successfully undergone IVUS-guided revascularization CTO at University Medical Center Mainz were analyzed. Angiography-based prediction for proximal and distal vessels was implanted diameter after IVUS assessment....
Abstract The risk of left ventricular (LV) and right (RV) maladaptation after surgery for isolated primary mitral regurgitation (PMR) is poorly defined. We aimed to evaluate LV RV contractile function using speckle-tracking analysis alongside with quantification exercise tolerance in patients PMR valve surgery. All consecutive symptomatic undergoing between July 2015 May 2017 were prospectively enrolled. Sequential echocardiographic studies along clinical assessment performed before three...
Background: Right ventricular (RV) dysfunction has been linked to worse outcomes in patients undergoing TAVI. Assessment of RV function is challenging due its complex morphology. longitudinal strain (LS) assessed by speckle-tracking echocardiography (STE) a novel measure that may overcome most the limitations conventional echocardiographic parameters function. The aim current study was assess prognostic value LS TAVI and predictors long-term mortality. Methods results: A retrospective...
Objectives Although procedure‐related new cardiac conduction disturbances (CCDs) remain an important issue in transcatheter aortic valve implantation (TAVI), their effect on myocardial function and overall patient outcome remains unclear. The goal of this study was to analyze the influence CCDs systolic diastolic LV performance survival after TAVI. Methods results Ninety‐five patients who underwent TAVI for severe symptomatic stenosis (AS) had a complete follow‐up were evaluated with respect...
We sought to determine the effects of use a Bioengineered Combo Dual-Therapy CD34 Antibody-Covered Sirolimus-Eluting Coronary Stent (Combo® DTS) in patients with chronic total occlusion (CTO) by evaluating clinical outcomes and performing an optical coherence tomography (OCT) analysis. retrospectively analyzed data from 39 who had successfully undergone OCT-guided revascularization CTO being treated Combo® DTS. Clinical assessment, angiography (with quantitative coronary analysis) OCT...