A5059578631- Antiplatelet Therapy and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Biomarkers in Disease Prognosis
- Lipoproteins and Cardiovascular Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Dermatology and Skin Diseases
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Signaling Pathways in Disease
- Ion channel regulation and function
- Vitamin D Research Studies
- Acute Myocardial Infarction Research
University Medical Center of the Johannes Gutenberg University Mainz
2018-2023
Johannes Gutenberg University Mainz
2018-2023
German Centre for Cardiovascular Research
2018-2022
University of Zurich
1998
Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify profibrotic coagulation signaling pathway that can be targeted improved function following with persistent ischemia. Quantitative phosphoproteomics tissue revealed an upregulated mitogen-activated protein kinase (MAPK) human IHF. Intervention this trametinib...
Introduction Cardiovascular diseases are characterized by altered platelet activity. To distinguish between physiological and pathological activity, it is essential to establish reference ranges of standardized (re)activity parameters in the population, which was a major aim this study. Furthermore, discriminative ability values outside these assessed for various cardiovascular diseases.
Introduction Enhanced platelet activity is associated with an increased risk of venous thromboembolism, in particular acute pulmonary embolism (PE) and less so for deep vein thrombosis. This study aimed to investigate function during after partial cessation antithrombotic therapies the post-acute stage PE.