A5072362582- Air Quality and Health Impacts
- Noise Effects and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Smoking Behavior and Cessation
- Adipose Tissue and Metabolism
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Climate Change and Health Impacts
University Medical Center of the Johannes Gutenberg University Mainz
2019-2022
Johannes Gutenberg University Mainz
2019-2022
Abstract Aims Electronic (e)-cigarettes have been marketed as a ‘healthy’ alternative to traditional combustible cigarettes and an effective method of smoking cessation. There are, however, paucity data support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction oxidative stress the vasculature lungs. The mechanisms underlying side effects remain unclear. Here, we investigated e-cigarette vapour on vascular function smokers experimental animals determine mechanisms....
Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance in mice response to chronic exposure. C57BL/6J were exposed aircraft 0, 4, 7, 14 28d at a mean sound pressure level of 72 dB(A) peak levels 85 dB(A). Chronic exposure up caused persistent dysfunction elevation blood pressure. Likewise, reactive oxygen...
Background: Reactive oxygen and nitrogen species (RONS such as H2O2, nitric oxide) are generated within the organism. Whereas physiological formation rates confer redox regulation of essential cellular functions provide basis for adaptive stress responses, their excessive contributes to impaired function or even cell death, organ dysfunction severe disease phenotypes entire Therefore, quantification RONS knowledge tissue/cell/compartment-specific distribution is great biological clinical...
Background Electronic (e)‐cigarettes have been marketed as a “healthy” alternative to traditional combustible cigarettes and an effective method of smoking cessation. There are, however, paucity data support these claims. In fact, e‐cigarettes are implicated in endothelial dysfunction oxidative stress the vasculature lungs. The mechanisms underlying side effects remain unclear. Here, we investigated e‐cigarette vapor on vascular function smokers experimental animals determine mechanisms....
Background Transportation noise is recognized as an important cardiovascular risk factor. It was shown that traffic exposure associated with cerebro/cardiovascular diseases such hypertension, myocardial infarction, and stroke. Aircraft causes endothelial dysfunction, inflammation increases cerebral/cardiovascular oxidative stress in mice general increased stroke mortality large population studies. Chronic aircraft also learning memory impairment children. We recently studied the effects of...
Background Oxidative stress was identified as a hallmark of almost all cardiovascular and neurodegenerative diseases. The term oxidative describes condition that is either characterized by increased generation reactive oxygen nitrogen species (RONS) and/or dysregulated cellular antioxidant defense mechanisms (e.g. decreased expression central enzymes). Since the transition between redox signaling thin line, exact knowledge identity formed species, subcellular localization their formation...