A5050165644- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Autism Spectrum Disorder Research
- Anatomy and Medical Technology
- Neurogenesis and neuroplasticity mechanisms
- Noise Effects and Management
- History of Medical Practice
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Congenital heart defects research
- Genetic Neurodegenerative Diseases
- Colorectal Cancer Surgical Treatments
- Stress Responses and Cortisol
- Air Quality and Health Impacts
- Craniofacial Disorders and Treatments
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Nerve injury and regeneration
University Medical Center of the Johannes Gutenberg University Mainz
2020-2025
Johannes Gutenberg University Mainz
2020-2025
Noise pollution is a known health risk factor and evidence for cardiovascular diseases associated with traffic noise growing. At least 20% of the European Union’s population lives in noise-polluted areas exposure levels exceeding recommended limits World Health Organization, which considered unhealthy by Environment Agency. This results annual loss 1.6 million healthy life years. Here, we investigated protective effects drug interventions against aircraft noise-mediated complications such as...
Autism spectrum disorder (ASD) comprises a wide range of neurodevelopmental phenotypes united by impaired social interaction and repetitive behavior. Environmental genetic factors are associated with the pathogenesis ASD, while other cases classified as idiopathic. The dopaminergic system has profound impact in modulation motor reward-motivated behaviors, defects circuits implicated ASD. In our study, we compare three well-established mouse models one idiopathic, BTBR strain, two syndromic,...
Synaptic signaling depends on ATP generated by mitochondria. Dysfunctional mitochondria shift the redox balance towards a more oxidative environment. Due to extensive connectivity, striatum is especially vulnerable mitochondrial dysfunction. We found that neuronal calcium-binding protein 2 (NECAB2) plays role in striatal function and homeostasis. NECAB2 predominantly endosomal which partially colocalizes with This colocalization enhanced mild stress. Global knockout of Necab2 mouse results...
<p>The World Health Organization (WHO) estimates that noise pollution leads to the loss of 1.6 million healthy life years annually in Western Europe alone, primarily due night-time exposure which disrupts sleep and triggers stress responses. This study investigates adverse health effects aircraft on brain-heart-vessel axis, combining cardiovascular neuropsychiatric approaches. We aim characterize functional biochemical consequences both short-term long-term utilizing an...
Early life events shape neuronal networks, and prime juvenile adult behavior. Severely aversive, early experiences can interfere with brain development enhance the risk for onset of psychiatric illnesses. Recent evidence has implicated oligodendrocyte precursor cells (OPCs) in pathophysiology stress-related mental disorders. Historically classified as precursors myelinating oligodendrocytes, OPCs are now known to fine-tune activity modify their proliferation-maturation dynamics response...
Carl Florian Toldt was an Austrian anatomist who made meaningful contributions worldwide and defined what is one of the most important surgical landmarks in abdominal surgery. Through his research studies, embryologic dissection plane known as “White Line Toldt” represents anatomical landmark that helps to mobilize either ascending or descending colon. His career spanned over 45 years, beginning Verona continuing Prague Vienna. He author several innovative books scientific articles regarding...
Autism spectrum disorder (ASD) comprises a wide range of neurodevelopment conditions primarily characterized by impaired social interaction and repetitive behavior, accompanied variable degree neuropsychiatric characteristics. Synaptic dysfunction is undertaken as one the key underlying mechanisms in understanding pathophysiology ASD. The excitatory/inhibitory (E/I) hypothesis most widely held theories for its pathogenesis. Shifts E/I balance have been proven several ASD models. In this...
Abstract Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable mitochondrial dysfunction and thus requires efficient quality control repair. We found that global knockout of neuronal calcium-binding protein 2 (NECAB2) in mouse causes loss striatal synapses behavioral phenotypes related such as reduced motivation altered sensory gating. Striatal mitochondria from Necab2 mice are more abundant smaller. They...