A5021756389- Dental materials and restorations
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Spectroscopy Techniques in Biomedical and Chemical Research
- Endodontics and Root Canal Treatments
- Dental Erosion and Treatment
- Dental Health and Care Utilization
- Engineering Technology and Methodologies
- Laser Applications in Dentistry and Medicine
- Dental Implant Techniques and Outcomes
- Medical and Biological Sciences
- Orthodontics and Dentofacial Orthopedics
- Temporomandibular Joint Disorders
- Spectroscopy and Chemometric Analyses
- Bone and Dental Protein Studies
- Bee Products Chemical Analysis
- Dental Trauma and Treatments
- Salivary Gland Disorders and Functions
- Dental Research and COVID-19
- Polymer Surface Interaction Studies
- Facial Trauma and Fracture Management
- Oral Health Pathology and Treatment
- Polymer Synthesis and Characterization
- Calcium Carbonate Crystallization and Inhibition
- Medical and Biological Ozone Research
Voronezh State Medical Academy named after N.N. Burdenko
2016-2025
Voronezh State University
2024
Ministry of Health of the Russian Federation
2020
In 2019, the EPMA celebrated its 10th anniversary at 5th World Congress in Pilsen, Czech Republic. The history of International Professional Network dedicated to Predictive, Preventive and Personalised Medicine (PPPM / 3PM) is rich achievements. Facing coronavirus COVID-19 pandemic it getting evident globally that predictive approach, targeted prevention personalisation medical services optimal paradigm healthcare demonstrating high potential save lives benefit society as a whole. Supplement...
The aim of the paper is to study phase transformations in solid tissues human teeth during development fissure caries by Raman and fluorescence microspectroscopy. areas with confirmed assumption formation a weak interaction between phosphate apatite enamel organic acids (products microorganisms). experimental results obtained microspectroscopy showed dicalcium dihydrate - CaHPO4-2H2O area mural demineralization carious fissure. A comparative analysis structural spectroscopic data for intact...
Relevance. The evaluation of masticatory patterns in children with normal and distal occlusion is essential for identifying potential morphological functional disorders the maxillofacial region determining need corrective interventions. Objective. To examine (Class II, Division 1). Materials Methods. study encompassed a total 104 aged 9 to 12 years, who were allocated into two groups: 67 1) 37 occlusion. was conducted over period six months. Results. In occlusion, proportion exhibiting...
Relevance. Limited scientific literature exists on the compositional relationship between dentinal fluid and gingival crevicular fluid, as well their potential interaction. Objective. This study aims to determine origin of compare its composition with that capillary blood, assess for Materials methods. analyzed three biological fluids: blood. A total 35 volunteers participated in study. The fluids were examined using an infrared microspectrometer at Australian Synchrotron. Additionally,...
The paper proposes a strategy for the accelerated deposition of biomimetic organomineral layers on surface dental enamel, utilizing di/tetrahydroquinolinediol (hydroxyquinoline) polymerized in presence nanocrystalline hydroxyapatite (nano-cHAp). mechanisms underlying formation coatings were elucidated through combination structural, microstructural, and spectroscopic analytical methods, including synchrotron infrared nanoimaging. Additionally, antimicrobial effects these investigated. It has...
Introduction. The article analyzes the problems associated with treatment of apical periodontitis single-root and multi-root teeth, burdened by absence constriction, periradicular destruction bone tissue internal root resorption. frequency patients due to need for endodontic dental destructive does not tend decrease Goal. search a solution problem in registered patents scientific literature. Materials methods. Analysis methods periodontitis, presented three Russian literature, including use...
The article is devoted to the analysis of regional hemodynamic parameters in patients with ankyloglossia before and after surgical complex therapy this pathology. During study, were divided into three groups: control group, group 1 2. included free parabola hyoid space. Group 2-3 degree according Kotlow classification who treated therapy. 2 consisted for whom only frenulotomy was performed. Hemodynamic microcirculatory channel evaluated using ultrasonic Doppler ultrasonography at rest during...
This study investigated the luminescence characteristics of synthesized biocomposites similar in organic and mineral composition to native dental tissues, enamel dentine. It was found that spectrum intact is calcium hydroxyapatite (HAP) used synthesize biomimetic materials. Despite morphological differences between biocomposite tissue, their spectra suggest shape more influenced by defects crystal structure employed than order apatite nanocrystals typical tissues. The human dentine possessed...
This study is aimed at investigating the features of mineralization enamel apatite initial stages fluorosis development. Samples teeth with intact and fluorotic in an early stage disease development (Thylstrup-Fejerskov Index = 1-3) were studied by Raman scattering FTIR using Infrared Microspectroscopy beamline Australian Synchrotron equipment. Based on data obtained optical microspectroscopy calculation coefficient R [A-type/B-type], which represents ratio carbonation fraction CO32-,...
The objective of this study was to investigate the efficiency saturation mixed saliva by mineral complexes and groups necessary for remineralisation tooth enamel using exogenous endogenous methods caries prevention. Using IR spectroscopy high-intensity synchrotron radiation, changes in composition human were identified when prevention are employed. Based on calculations mineral/organic carbon/phosphate ratios, depending a certain type identified. It is shown that use toothpaste (exogenous...
In this exploratory study, we searched for associations between the two most common diseases of oral cavity—dental caries and periodontal diseases—taking into account additional factors, such as personalized clinical pictures (the individual risk factors patient), based on method a multivariate data analysis molecular changes in composition human gingival crevicular fluid (GCF). For purpose, set synchrotron Fourier-transform infrared spectroscopy (FTIR) spectra samples from patients with...
Investigations of intact dental enamel as well carious-affected human were performed using infrared spectromicroscopy and X-ray diffraction applying synchrotron radiation. Caries was shown to be characterized by an increase in the number deformation valence vibrations for N-C-O, N-H C=O bonds, a decrease crystallinity index, absence preferable orientation hydroxyapatite crystals within affected enamel. This indicates presence destructive processes organic matrix hard tooth tissues.
In this report, we demonstrated the formation of a biomimetic mineralizing layer obtained on surface dental enamel (biotemplate) using bioinspired nanocrystalline carbonate-substituted calcium hydroxyapatite (ncHAp), whose physical and chemical properties are closest to natural apatite matrix, together with complex polyfunctional organic polar amino acids. Using set structural, spectroscopy, advanced microscopy techniques, confirmed nanosized ncHAp-based mineralized layer, as well studying...
In our paper, we discuss the results of a comprehensive structural-spectroscopic and microscopic analysis non-stoichiometric nanocrystalline hydroxyapatite (CHAp) with low carbonate anion content biomimetic hybrid nanomaterials produced on its basis. It was shown that nanocrystals synthesized by chemical precipitation biogenic calcium source mimic properties apatite also have morphological organization “core–shell” type. The “core” CHAp nanocrystal is characterized an overabundance Ca/P~1.9....
The aim of this work is to develop a biomimetic interface between the natural tooth tissue and restorative composite study it on basis synchrotron micro-FTIR mapping multidimensional processing spectral data array. Using hierarchical cluster analysis 3D FTIR revealed marked improvements in formation dentine/adhesive/dental hybrid using approach. use strategy (application an amino acid-modified primer, alkaline calcium nano-c-HAp-modified adhesive) allowed matrix that can be structurally...
(1) Objectives: This study is the first one to investigate molecular composition of dental biofilm during exogenous and endogenous prophylaxis stages (use dentifrice/drug) individuals with different cariogenic conditions using spectroscopy methods. (2) Materials Methods: The involved 100 participants (50 males 50 females), aged 18-25 years caries conditions. Biofilm samples were collected from teeth surface all participants. biofilms was investigated synchrotron infrared microspectroscopy....
The work presents microspectroscopic studies of the caries development and phase formation in dentin tissues using methods laser-induced fluorescence (LIF) Raman spectroscopy. results show that data obtained near boundary intact infected by these two under simultaneous scanning from micro-regions confirm complement each other. analysis LIF spectra proves detected bands spectroscopy can be referred to porphyrins, amino acids DNA/RNA microorganisms. In this fact appears "red" region a band...
Background ― Changes in the molecular composition of mixed human saliva using endogenous and exogenous methods caries prevention were studied duration these changes relation to initial state oral fluid was determined. Material Methods In total, 200 European healthy, addiction-free, university-educated males females, aged 22–30 recruited for study. Participants collected their samples after use a multi-mineral toothpaste (exogenous prevention) three days taking calcium glycerophosphate tablet...
In this work, we developed a technology that enables rapid deposition of biomimetic composite films onto natural enamel slices (known as biotemplates). These are composed polydopamine (PDA) and nanocrystalline carbonate-substituted hydroxyapatite (nano-cHAp) have been functionalized with amino acid l-Arginine. We utilized atomic force microscopy (AFM) scattering scanning near-field optical (s-SNOM) combined infrared (IR) synchrotron to achieve nanoscale spatial resolution for both IR...
The aim of our work is to find a spectroscopic signature the pathological processes carious dentine based on investigations molecular composition oral biological fluids with use FTIR synchrotron techniques.This complex analysis obtained data shows that number signatures are present only in spectra and gingival from patients developing caries deep tissues.The detected features quantitative qualitative representing development cavity pathologies can enhance quality dental screening.
This study investigated changes in the interaction of B-type non-stoichiometric nanocrystalline carbonate-substituted hydroxyapatite (nano-CHAP) with polar amino acids (AA) respect to CHAP-AA linking. Molecular vibrational spectroscopy revealed for first time that surface defective nano-CHAP is determined not only by charge state AA but can be mediated a foreign ion conjugated lateral bonds acids. Understanding this mechanism required development new generation dental biomimetic materials...
In this short communication, we provide information on the use of hierarchical cluster analysis synchrotron ATR-FTIR 2D chemical imaging spectral data as a useful and powerful approach to microspectroscopic diagnostics molecular composition in hybrid sound dentin/dental composite interfaces materials, including ones developed with biomimetic strategies. The described diagnostic can be successfully transferred visualisation data, collected using laboratory Raman FTIR microspectroscopy techniques.
In this letter, we provide information on the engineering of biomimetic layer between human dentin and dental material, use multivariate statistical analysis synchrotron spectral data for determination molecular composition integration mechanisms hybrid native hard tissue.