A5087060119- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Crystallization and Solubility Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- X-ray Diffraction in Crystallography
- Chemical Reaction Mechanisms
- Multicomponent Synthesis of Heterocycles
- Chemical synthesis and pharmacological studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Corrosion Behavior and Inhibition
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Computational Drug Discovery Methods
- Synthesis and Characterization of Pyrroles
- Chemical Synthesis and Analysis
- Synthesis of Organic Compounds
- Free Radicals and Antioxidants
- Synthesis and Catalytic Reactions
- Allelopathy and phytotoxic interactions
- Chemical Synthesis and Reactions
- Material Properties and Applications
Voronezh State University
2016-2025
University of Gondar
2024
Frumkin Institute of Physical Chemistry and Electrochemistry
2022
Scientific Research Institute of Agriculture of the Central Black Earth Zone named after V.V. Dokuchaeva
2022
Belarusian State University
2021
Lomonosov Moscow State University
2018
Azerbaijan State Oil and Industry University
2013
Semenov Institute of Chemical Physics
1991
Russian Academy of Sciences
1988-1989
In consequence of the key role factor Xa in clotting cascade and absence its activity processes that do not affect coagulation, this protein is an attractive target for development new blood coagulation inhibitors. Factor more effective convenient creation anticoagulants than thrombin, inhibition which may cause some side effects. This study aimed at finding inhibitors by molecular computer modeling including docking SOL postdocking optimization DISCORE programs. After validation methods on...
The paper proposes a strategy for the accelerated deposition of biomimetic organomineral layers on surface dental enamel, utilizing di/tetrahydroquinolinediol (hydroxyquinoline) polymerized in presence nanocrystalline hydroxyapatite (nano-cHAp). mechanisms underlying formation coatings were elucidated through combination structural, microstructural, and spectroscopic analytical methods, including synchrotron infrared nanoimaging. Additionally, antimicrobial effects these investigated. It has...
Among the fused azaheterocycles, quinolines have long attracted attention of chemists. First all, this is due to their wide range practically useful properties. Quinolines and derivatives exhibit a biological activities, including antimalarial, anticancer, antiviral, antifungal anti-inflammatory activities. These compounds are also used as fluorescent probes, luminescent labels, in dye production. In course work, series pyridocoumarin systems been obtained, which tested inhibitors blood...
Coagulation factor Xa and XIa are proven to be convenient crucial protein targets for treatment thrombotic disorders thereby their inhibitors can serve as effective anticoagulant drugs. In the present work, we focused on structure–activity relationships of derivatives pyrrolo[3,2,1-ij]quinolin-2(1H)-one an evaluation activity against XIa. For this, docking-guided synthesis nine compounds based was carried out. new hybrid hydropyrrolo[3,2,1-ij]quinolin-2(1H)-one derivatives, used structural...
In the modern world, complications caused by disorders in blood coagulation system are found almost all areas of medicine. Thus, development new, more advanced drugs that can prevent pathological conditions without disrupting normal hemostasis is an urgent task. The factor XIIa one most promising therapeutic targets for anticoagulants based on its inhibitors. initial stage drug directly related to computational methods searching a lead compound. this study, docking followed quantum chemical...
Esters with acyl groups can be formed by the esterification of polyglycerol. The purpose present study was to produce fatty acid esters [hexanoic (caproic), octanoic (caprylic), decanoic (capric), dodecanoic (lauric), tetradecanoic (myristic), hexadecanoic (palmitic), octadecanoic (stearic)] and polyglycerol (average number-of degrees polymerization 5) varying examine their emulsifying properties. A number fundamental catalysts acylation reactions methyl carboxylic were studied, sodium...
Inflammation and an increase in antioxidant responses mediated by oxidative stress play important role the pathogenesis of acute liver injury (ALI). We utilized silico prediction biological activity spectra for substances (PASS) analysis to estimate potential profile deethylated ethoxyquin (DEQ) hypothesized that DEQ exhibits anti-inflammatory effects a rat model carbon tetrachloride (CCl4)-induced ALI. Our results demonstrate improved function which was indicated reduction histopathological...
Despite extensive research in the field of thrombotic diseases, prevention blood clots remains an important area study. Therefore, development new anticoagulant drugs with better therapeutic profiles and fewer side effects to combat thrombus formation is still needed. Herein, we report synthesis evaluation novel pyrroloquinolinedione-based rhodanine derivatives, which were chosen from 24 developed derivatives by docking as potential molecules inhibit clotting factors Xa XIa. For hybrid...
The effect of the adsorption 5-mercaptopentyl-3-amino-1,2,4-triazole (MPATA) on corrosive behavior brass (Cu80/Zn20) in neutral (pH 7.4) borate buffer solutions with and without 0.01 M NaCl was studied. Electrochemical methods show significant decrease anodic cathodic currents polarization curves presence MPATA. X-ray photoelectron spectroscopy (XPS) reveals MPATA surface from an inhibitor solution. After 17 h exposure, a mixed complex [CuxZnyMPATAz] thickness about 3–3.5 nm is formed...
Pyridin‐2‐yl‐ and 4,6‐dimethylpyrimidin‐2‐yl‐cyanamides entered into an alkylation reaction in the form of sodium salts. Pyridin‐2‐yl cyanamide 2 was alkylated at endo‐nitrogen atom pyridine ring, while 4,6‐dimethylpyrimidin‐2‐yl 1 effectively exo‐nitrogen amino group. The cyanamides with phenacylbromide gave corresponding acetophenone derivatives. As a result their intramolecular cyclization reactions 3‐(4,6‐dimethylpyrimidin‐2‐yl)‐5‐phenyloxazol‐2(3 H )‐imine case...