A5091617945- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Reaction Mechanisms
- Synthesis and Biological Evaluation
- Organic Chemistry Cycloaddition Reactions
- Genetic Neurodegenerative Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Reactions and Mechanisms
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Mitochondrial Function and Pathology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
- Berberine and alkaloids research
- Crystallography and molecular interactions
- Synthesis and Reactions of Organic Compounds
- Synthesis of heterocyclic compounds
- Asymmetric Synthesis and Catalysis
- Neurological diseases and metabolism
- Muscle Physiology and Disorders
- Hereditary Neurological Disorders
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactivity of Heterocycles
- Organic and Inorganic Chemical Reactions
- Fluorine in Organic Chemistry
- Ion channel regulation and function
Voronezh State Medical Academy named after N.N. Burdenko
2021-2025
Saratov State Medical University
2024-2025
Southern Federal University
2015-2024
Institute of Physics and Technology
2024
Yaroslavl State University
2018-2021
Voronezh Regional Clinical Oncology Center
2014-2020
Promundo
2018
Consultative and Diagnostic Center
2012-2017
Counseling Center
2015
Institut Lavoisier de Versailles
2003-2013
The chemistry of heterocyclic compounds has traditionally been and remains a bright area chemical science in Russia. This is due to the fact that many heterocycles find widest application. These are key structural fragments most drugs, plant protection agents. Many natural also derivatives heterocycles. At present, more than half hundreds millions known collective review devoted achievements Russian chemists this field over last 15–20 years. presents leading heterocyclists representing both...
Hereditary myopathy with early respiratory failure (HMERF) is caused by titin A-band mutations in exon 344 and considered quite rare. Respiratory insufficiency an symptom. A collection of families patients muscle disease suggestive HMERF was clinically genetically studied. Altogether 12 new 19 affected diverse nationalities were Most the investigated using targeted next-generation sequencing; Sanger sequencing applied some available family members. Histological data MRI findings evaluated....
Leigh syndrome (LS), also known as infantile subacute necrotizing encephalopathy, is the most frequent mitochondrial disorder in children. Recently, more than 80 genes have been associated with LS, which greatly complicates diagnosis. In this article, we present clinical and molecular findings of 219 patients LS give detailed description three cases rare nuclear MORC2, NARS2 VPS13D, demonstrating wide genetic heterogeneity disease. The common cause Russian are pathogenic variants SURF1 gene...
LAMA2-associated muscular dystrophy is a rare genetic disorder caused by pathogenic or likely variants in the LAMA2 gene. The aim of this study to characterize spectrum pathogenic/likely gene among Russian patients, identify frequent specific population, and estimate prevalence Russia. Data were collected analyzed from patients with confirmed diagnoses using various molecular methods research centers 2008 2024. obtained 90 unrelated dystrophy, out which 83 presented more severe form, MDC1A1,...
ABSTRACT Spinal muscular atrophy 5q (5q SMA) is one of the most prevalent autosomal recessive disorders globally. The underlying cause SMA attributed to variants in SMN1 . Exon 7 not detectable major probands with SMA, and minor have a combination deletion an intragenic subtle variant second allele. From 1991 2023, DNA samples from 2796 representing unrelated families were analyzed at Research Centre for Medical Genetics diagnosis SMA. copy number SMN2 was determined all by MLPA....
Superelectrophilic 7-chloro-4,6-dinitrobenzofuroxan (DNBF-Cl) and 7-chloro-4,6-dinitrobenzofurazan (DNBZ-Cl) are shown to undergo facile carbon−carbon couplings with a series of weak carbon nucleophiles consisting number differently substituted indoles, 1,2,5-trimethylpyrrole azulene, in acetonitrile. Despite the fact that steric effects preclude coplanarity donor acceptor moieties, resulting substitution products subject an intense intramolecular charge transfer. A kinetic study various...
We developed a microfluidic synthesis with UV-Vis diagnostics using 3D printed chip for 8,13-disubstituted berberines. This system yielded up to 30% higher product yields high antioxidant activity compared traditional batch synthesis.
Abstract The mechanism of the Diels–Alder interaction 4‐nitrobenzodifuroxan (NBDF) with cyclopentadiene (Cp), resulting in highly stereoselective formation stable endo [2+4] adduct has been elucidated by combining density functional theory (DFT) and experimental studies. Calculations at B3LYP/6‐31G* level reveal that this does not derive from a direct normal electron demand cycloaddition process. Instead, evidence is proceeds initially through very polar inverse process to afford...
The kinetics of the coupling 4-nitrobenzodifuroxan (NBDF) with a series indoles 8 a-e to give expected Michael-type adducts 9 have been investigated in acetonitrile solution. No significant influence nature isotopic substitution at C-3 indole ring has found, indicating that NBDF addition step is rate limiting SEAr moiety. This implies measured second-order constants (k) for reactions are identical second order (k1NBDF) associated C--C step. By using known N and s parameters characterizing...
Nucleophilic aromatic substitutions (SNAr reactions) together with the formation of related σ-anionic adducts are reactions great importance in organic synthesis. 1 – 4 Scheme describes a ...
Abstract The Diels–Alder reaction of 4‐nitrobenzodifuroxan (NBDF) with 1‐methoxy‐3‐trimethylsilyloxy‐1,3‐butadiene has been investigated experimentally and theoretically. Treatment NBDF excess diene in chloroform at room temperature was found to afford a single product that contained carbonyl functionality. Based on an X‐ray structure NMR spectroscopic data, the appeared be result hydrolysis OSiMe 3 moiety thermodynamically more stable endo [2+4] cycloadduct, characterized by cis arrangement...
Superelectrophilic halonitro-2,1,3-benzoxadiazoles under-go remarkably facile carbon–carbon couplings with some electron-rich aromatics and heteroaromatics, affording quantitatively products exhibiting an intense visible absorption due to strong intramolecular charge transfer.
Coupling of superelectrophilic 4,6-dinitrobenzofuroxan with a π-excessive indolizine structure affords strongly dipolar substitution product which undergoes facile but unusual rearrangement induced by an intramolecular oxygen atom transfer from the N-oxide functionality DNBF moiety.
A new approach for the annulation of a thiopyrane ring to an indole core under mild conditions was developed. Treating 2-methyl-3-acylindoles with lithium diisopropyl amide leads elimination proton from 2-methyl group. The indole-2,3-dienolates obtained were found react CS2 give corresponding thiopyrano[4,3-b]indole-3(5H)-thiones. mechanism represents stepwise addition through ion-pair formation, according PCM/B3LYP/6-311++G**, PBE1PBE/6-311++G**, and MP2//HF/6-311++G** quantum chemical...