A5063237967- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organic and Inorganic Chemical Reactions
- Synthesis of heterocyclic compounds
- Organophosphorus compounds synthesis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Synthesis and biological activity
- Chemical Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Chemical synthesis and alkaloids
- Synthesis of Organic Compounds
- Phosphorus compounds and reactions
- Chemical Synthesis and Reactions
- Synthesis and Reactivity of Heterocycles
- Catalytic C–H Functionalization Methods
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Pyrroles
- Structural and Chemical Analysis of Organic and Inorganic Compounds
A.E. Arbuzov Institute of Organic and Physical Chemistry
2015-2024
Research Center for Ecology and Environment of Central Asia
2024
Kazan Scientific Center
2017-2021
ShanghaiTech University
2020
Riga Technical University
2020
Russian New University
2020
Peoples' Friendship University of Russia
2020
A.E. Favorsky Irkutsk Institute of Chemistry
2020
Russian Academy of Sciences
2006-2017
The chemistry of heterocyclic compounds has traditionally been and remains a bright area chemical science in Russia. This is due to the fact that many heterocycles find widest application. These are key structural fragments most drugs, plant protection agents. Many natural also derivatives heterocycles. At present, more than half hundreds millions known collective review devoted achievements Russian chemists this field over last 15–20 years. presents leading heterocyclists representing both...
The electrophilic activation of various substrates via double or even triple protonation in superacidic media enables reactions with extremely weak nucleophiles. Despite the significant progress this area, utility organophosphorus compounds as superelectrophiles still remains limited. Additionally, most common superacids require a special care due to their high toxicity, exceptional corrosiveness and moisture sensitivity. Herein, we report first successful application “Brønsted acid assisted...
Published data on ring opening reactions of nitrogen-containing cyclic compounds resulting in various acyclic products are integrated and systematized. The common five-, six- seven-membered nitrogen heterocycles containing one to four atoms the having structures (mononuclear, polynuclear, fused, saturated, unsaturated aromatic) considered. Special emphasis is made potential for synthesis polyfunctional open-chain compounds. advantages disadvantages proposed approaches noted. Data biological...
Herein, we report the design and synthesis of novel 7-aza-coumarine-3-carboxamides via scaffold-hopping strategy evaluation their in vitro anticancer activity. Additionally, improved non-catalytic 7-azacoumarin-3-carboxylic acid is reported, which features water as reaction medium provides a convenient alternative to known methods. The activity most potent against HuTu 80 cell line equal that reference Doxorubicin, while selectivity towards normal 9-14 fold higher.
A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and vivo tested. The activity some compounds towards M-Hela tumor cell lines was twice that reference drug tamoxifen, whereas cytotoxicity normal Chang liver did not exceed tamoxifen toxicity. In studies showed number surviving animals day 60 observation up to 83%...
The review systematizes and summarizes data on the synthesis of structurally diverse cyclic ureas published over last 10 years. Saturated unsaturated monocyclic ureas, as well fused heterocycles containing one urea moiety, are considered. Data biological activity selected compounds this type provided. synthetic approaches to carbamides classified in terms reaction source a carbonyl group. bibliography includes 235 references.
The series of novel taurine-derived diarylmethanes and dibenzoxanthenes was synthesized starting from simple commercially available precursors via modular three-stage approach. All the newly compounds were screened for in vitro antibacterial antifungal activity, as well cytotoxicity towards normal cancer cell lines. Some exhibited 2-4-fold higher activity against S. aureus, E. faecalis B. cereus compared with Chloramphenicol. In contrast to Chloramphenicol, tested also showed bactericidal,...
Ureas are often thought of as "double amides" due to the obvious structural similarity these functional groups. The main feature an amide is its planarity, which responsible for conjugation between nitrogen atom and carbonyl moiety decrease nucleophilicity. Consequently, since amides poor nucleophiles, ureas nucleophiles well. Herein, we demonstrate that can be distinctly different from amides. These differences amplified by rotation around one ureas' C-N bonds, switches off resonance...
A novel tandem reaction, which transforms <italic>N</italic>-(4,4-diethoxybutyl)imines to 3-arylidene-1-pyrrolines <italic>via</italic> intramolecular Mannich reaction/[1,3]-sigmatropic rearrangement of the aryl fragment is described.
1-(4,4-Diethoxybutyl)-3-alkylureas undergo intramolecular cyclization in the presence of trifluoroacetic acid and various phenols, leading to new N-alkyl-2-arylpyrrolidine-1-carboxamides with moderate excellent yields. It was found that these compounds spontaneous solid-phase epimerization at room temperature. Advantages proposed approach are mild reaction conditions no need for expensive reagents or catalysts.
Method of synthesis aryl substituted bis(pyrrolidine-1-carboxamides) has been developed based on acid-catalyzed reaction γ-ureidoacetals with polyatomic phenols.Advantages the method are high yield target products, mild conditions, and no need for expensive reagents.
Herein, we report a highly regioselective one-pot synthesis of pyrazolo[3,4-b]pyridines via the reaction 3-arylidene-1-pyrrolines with aminopyrazoles. The proceeds through sequential nucleophilic addition/electrophilic substitution/C-N bond cleavage and provides easy access to pyrazolo[3,4-b]pyridine derivatives featuring primary amino group. Moreover, can be terminated at electrophilic substitution stage, thus providing convenient entry hardly accessible pyrazolopyrrolopyridine scaffold.
A new method based on the acid-catalyzed reaction of pyridoxal with polyfunctional phenols has been developed for synthesis potentially biologically active 1-aryl-6-methyl-1,3-dihydrofuro[3,4-<i>c</i>]pyridin-7-ols. Advantages this include a good yield target furopyridines and use readily available hydrochloric acid as catalyst. The possibility extending proposed approach to nucleophiles other than was demonstrated by known compound...
Pyrrolidine-based phosphonates, analogues of the natural amino acid proline, possess a diverse set biological activity. The goal this short review is to summarize major developments in synthesis phosphaproline derivatives reported since 2004 with special emphasis on mechanisms and limitations methods presented. 1 Introduction 2 Phosphorylation Pyrrolidine Derivatives 2.1 Syntheses via Pudovik Reaction 2.2 Arbuzov 2.3 Decarboxylative Proline 2.4 Direct C–H Bond 2.5 Other Reactions 2.6...
Herein we report our studies on the acid-catalyzed cyclisation of N-(4,4-diethoxybutyl)sulfonamides at presence polyatomic phenols as an efficient one-pot approach to synthesis 1-sulfonyl-2-arylpyrrolidines from acyclic precursors.
A series of novel 4-(het)arylimidazoldin-2-ones were obtained by the acid-catalyzed reaction (2,2-diethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones benefits from excellent regioselectivity, readily available starting materials a simple procedure. regioselectivity was rationalized quantum chemistry calculations control experiments. anti-cancer activity compounds tested in vitro.