A5060085599- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organophosphorus compounds synthesis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Supramolecular Chemistry and Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Phosphorus compounds and reactions
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Organic and Inorganic Chemical Reactions
- Porphyrin and Phthalocyanine Chemistry
- Chemical Reaction Mechanisms
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis of Organic Compounds
- Fluorine in Organic Chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Chemical Reactions and Mechanisms
- Synthesis and characterization of novel inorganic/organometallic compounds
A.E. Arbuzov Institute of Organic and Physical Chemistry
2015-2024
Russian Academy of Sciences
2010-2021
Kazan Scientific Center
2016-2021
Kazan State Technological University
2002-2021
ShanghaiTech University
2020
Riga Technical University
2020
Russian New University
2020
Peoples' Friendship University of Russia
2020
A.E. Favorsky Irkutsk Institute of Chemistry
2020
West Pomeranian University of Technology
2019
The electrophilic activation of various substrates via double or even triple protonation in superacidic media enables reactions with extremely weak nucleophiles. Despite the significant progress this area, utility organophosphorus compounds as superelectrophiles still remains limited. Additionally, most common superacids require a special care due to their high toxicity, exceptional corrosiveness and moisture sensitivity. Herein, we report first successful application “Brønsted acid assisted...
Main trends in the development of methods for synthesis phosphorus-containing macrocyclic compounds past 15 years are considered. Emphasis is given to reactions producing structures with participation a phosphorus atom and other functional groups involved organophosphorus molecules modifications macrocycles by different valence states. Possibilities practical application difference areas science engineering discussed. The bibliography includes 205 references.
Published data on ring opening reactions of nitrogen-containing cyclic compounds resulting in various acyclic products are integrated and systematized. The common five-, six- seven-membered nitrogen heterocycles containing one to four atoms the having structures (mononuclear, polynuclear, fused, saturated, unsaturated aromatic) considered. Special emphasis is made potential for synthesis polyfunctional open-chain compounds. advantages disadvantages proposed approaches noted. Data biological...
Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically hindered phenols with dinitrobenzofuroxan fragments exhibit broad range of biological activities. The modular assembly such phenol/benzofuroxan hybrids allows variations the ratio. Interestingly, antimicrobial activity only appears when at least benzofuroxan moieties are introduced per phenol. most potent synthesized compounds high cytotoxicity against...
Herein, we report the design and synthesis of novel 7-aza-coumarine-3-carboxamides via scaffold-hopping strategy evaluation their in vitro anticancer activity. Additionally, improved non-catalytic 7-azacoumarin-3-carboxylic acid is reported, which features water as reaction medium provides a convenient alternative to known methods. The activity most potent against HuTu 80 cell line equal that reference Doxorubicin, while selectivity towards normal 9-14 fold higher.
A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and vivo tested. The activity some compounds towards M-Hela tumor cell lines was twice that reference drug tamoxifen, whereas cytotoxicity normal Chang liver did not exceed tamoxifen toxicity. In studies showed number surviving animals day 60 observation up to 83%...
New lipid-based nanomaterials based on sterically hindered phenols were developed as potential drugs against Alzheimer's disease <italic>via</italic> intranasal administration.
The utility of sterically hindered phenols (SHPs) in drug design is based on their chameleonic ability to switch from an antioxidant that can protect healthy tissues highly cytotoxic species target tumor cells. This work explores the biological activity a family 45 new hybrid molecules combine SHPs equipped with activating phosphonate moiety at benzylic position additional urea/thiourea fragments. compounds were synthesized by reaction iso(thio)cyanates C-arylphosphorylated containing...
The review systematizes and summarizes data on the synthesis of structurally diverse cyclic ureas published over last 10 years. Saturated unsaturated monocyclic ureas, as well fused heterocycles containing one urea moiety, are considered. Data biological activity selected compounds this type provided. synthetic approaches to carbamides classified in terms reaction source a carbonyl group. bibliography includes 235 references.
The series of novel taurine-derived diarylmethanes and dibenzoxanthenes was synthesized starting from simple commercially available precursors via modular three-stage approach. All the newly compounds were screened for in vitro antibacterial antifungal activity, as well cytotoxicity towards normal cancer cell lines. Some exhibited 2-4-fold higher activity against S. aureus, E. faecalis B. cereus compared with Chloramphenicol. In contrast to Chloramphenicol, tested also showed bactericidal,...
Ureas are often thought of as "double amides" due to the obvious structural similarity these functional groups. The main feature an amide is its planarity, which responsible for conjugation between nitrogen atom and carbonyl moiety decrease nucleophilicity. Consequently, since amides poor nucleophiles, ureas nucleophiles well. Herein, we demonstrate that can be distinctly different from amides. These differences amplified by rotation around one ureas' C-N bonds, switches off resonance...
Abstract The condensation of 2‐ethoxyethenyl‐ phosphonic dichloride with resorcinol and its derivatives in dichloromethane the presence trifluoroacetic acid results formation new bicyclic phosphonates an endocyclic PC bond. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 22:1–4, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20646
Abstract The scheme of formation bicyclic phosphonates 3 synthesized on the basis resorcinol and its derivatives was suggested based model reactions dichloroanhydride 1 with 3‐methoxyphenol 7 in presence triethylamine a variable ratio reagents. Composition structure products obtained were confirmed according to H 31 P NMR, IR spectroscopy, elemental analysis, X‐ray analysis. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:340–344, 2012; View this article online at wileyonlinelibrary.com ....